Search Results - "Dart, M.J."

Design of ligands for the nicotinic acetylcholine receptors: the quest for selectivity by Bunnelle, William H, Dart, Michael J, Schrimpf, Michael R

“…In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important targets for drug discovery. The therapeutic potential of nicotinic…”
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A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors by McGaraughty, S, Chu, K.L, Dart, M.J, Yao, B.B, Meyer, M.D

“…Abstract We investigated the systemic and site-specific actions of a selective CB2 receptor agonist, A-836339 on mechanically evoked (10 g von Frey hair) and…”
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A selective α 2 B adrenoceptor agonist (A‐1262543) and duloxetine modulate nociceptive neurones in the medial prefrontal cortex, but not in the spinal cord of neuropathic rats by Chu, K.L., Xu, J., Frost, J., Li, L., Gomez, E., Dart, M.J., Jarvis, M.F., Meyer, M.D., McGaraughty, S.

“…Abstract Background The noradrenergic system contributes to pain modulation, but the roles of its specific adrenoceptors are still being defined. We have…”
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A selective α2B adrenoceptor agonist (A-1262543) and duloxetine modulate nociceptive neurones in the medial prefrontal cortex, but not in the spinal cord of neuropathic rats by Chu, K.L., Xu, J., Frost, J., Li, L., Gomez, E., Dart, M.J., Jarvis, M.F., Meyer, M.D., McGaraughty, S.

“…Background The noradrenergic system contributes to pain modulation, but the roles of its specific adrenoceptors are still being defined. We have identified a…”
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