Search Results - "Darrow, James W."

Novel Benzodiazepine Photoaffinity Probe Stereoselectively Labels a Site Deep within the Membrane-Spanning Domain of the Cholecystokinin Receptor by Hadac, Elizabeth M, Dawson, Eric S, Darrow, James W, Sugg, Elizabeth E, Lybrand, Terry P, Miller, Laurence J

“…An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and…”
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Imidazo[1,2-a]pyrazine diaryl ureas: Inhibitors of the receptor tyrosine kinase EphB4 by Mitchell, Scott A., Danca, Mihaela Diana, Blomgren, Peter A., Darrow, James W., Currie, Kevin S., Kropf, Jeffrey E., Lee, Seung H., Gallion, Steven L., Xiong, Jin-Ming, Pippin, Douglas A., DeSimone, Robert W., Brittelli, David R., Eustice, David C., Bourret, Aaron, Hill-Drzewi, Melissa, Maciejewski, Patricia M., Elkin, Lisa L.

“…The identification of imidazo[1,2-a]pyrazine diarylureas as potent inhibitors of the receptor tyrosine kinaseEphB4 is reported. Inhibition of receptor tyrosine…”
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Cyclic Phosphonate Analogs of Hexopyranoses by Darrow, James W, Drueckhammer, Dale G

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A cyclic phosphonamidate analogue of glucose as a selective inhibitor of inverting glycosidases by Darrow, James W., Drueckhammer, Dale G.

“…Recent work in the synthesis of cyclic phosphonate analogues of glucose [Darrow, J. W.; Drueckhammer, D. G. (1994) J. Org. Chem.1994, 59, 2976] has been…”
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Structurally similar small molecule photoaffinity CCK-A agonists and antagonists as novel tools for directly probing 7TM receptor-ligand interactions by Darrow, James W., Hadac, Elizabeth M., Miller, Laurence J., Sugg, Elizabeth E.

“…Incorporation of photolabile benzoyl ( 2a-d) or trifluoromethyl-3 H-diazirine ( 3a-d) substituents into 1,5-benzodiazepine ligands did not significantly impair…”
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