Search Results - "Darpel, Karin E"

Measurement of the infection and dissemination of bluetongue virus in culicoides biting midges using a semi-quantitative rt-PCR assay and isolation of infectious virus by Veronesi, Eva, Antony, Frank, Gubbins, Simon, Golding, Nick, Blackwell, Alison, Mertens, Peter Pc, Brownlie, Joe, Darpel, Karin E, Mellor, Philip S, Carpenter, Simon

“…Culicoides biting midges (Diptera: Ceratopogonidae) are the biological vectors of globally significant arboviruses of livestock including bluetongue virus…”
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A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host by Stevens, Lisa M, Moffat, Katy, Cooke, Lyndsay, Nomikou, Kyriaki, Mertens, Peter P C, Jackson, Terry, Darpel, Karin E

“…Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In…”
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Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus by Newbrook, Kerry, Khan, Nakibul, Fisher, Aimee, Chong, Karen, Gubbins, Simon, Davies, William C, Sanders, Christopher, Busquets, Marc Guimerà, Cooke, Lyndsay, Corla, Amanda, Ashby, Martin, Flannery, John, Batten, Carrie, Stokes, Jessica E, Sanz-Bernardo, Beatriz, Carpenter, Simon, Moffat, Katy, Darpel, Karin E

“…Bluetongue virus (BTV) is an arthropod-borne that is almost solely transmitted by biting midges and causes a globally important haemorrhagic disease,…”
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An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins by Guimerà Busquets, Marc, Pullinger, Gillian D, Darpel, Karin E, Cooke, Lyndsay, Armstrong, Stuart, Simpson, Jennifer, Palmarini, Massimo, Fragkoudis, Rennos, Mertens, Peter P C

“…Arboviruses such as bluetongue virus (BTV) replicate in arthropod vectors involved in their transmission between susceptible vertebrate-hosts. The "classical"…”
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Visualisation of Bluetongue Virus in the Salivary Apparatus of Culicoides Biting Midges Highlights the Accessory Glands as a Primary Arboviral Infection Site by Guimerà Busquets, Marc, Brown, Faye V, Carpenter, Simon T, Darpel, Karin E, Sanders, Christopher J

“…Abstract Background Arthropods transmit a wide range of pathogens of importance for the global health of humans, animals, and plants. One group of these…”
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Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions by Tugwell, Laura A, England, Marion E, Gubbins, Simon, Sanders, Christopher J, Stokes, Jessica E, Stoner, Joanne, Graham, Simon P, Blackwell, Alison, Darpel, Karin E, Carpenter, Simon

“…Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans,…”
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Identification of a BTV-Strain-Specific Single Gene That Increases Culicoides Vector Infection Rate by Ropiak, Honorata M, King, Simon, Busquets, Marc Guimerà, Newbrook, Kerry, Pullinger, Gillian D, Brown, Hannah, Flannery, John, Gubbins, Simon, Batten, Carrie, Rajko-Nenow, Paulina, Darpel, Karin E

“…Since the 2000s, the distribution of bluetongue virus (BTV) has changed, leading to numerous epidemics and economic losses in Europe. Previously, we found a…”
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Investigation of bovine ephemeral fever virus transmission by putative dipteran vectors under experimental conditions by Stokes, Jessica E, Darpel, Karin E, Gubbins, Simon, Carpenter, Simon, Fernández de Marco, María Del Mar, Hernández-Triana, Luis M, Fooks, Anthony R, Johnson, Nicholas, Sanders, Christopher

“…Bovine ephemeral fever virus (Rhabdoviridae: Ephemerovirus) (BEFV) causes bovine ephemeral fever (BEF), an economically important disease of cattle and water…”
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein by Darpel, Karin E., Corla, Amanda, Stedman, Anna, Bellamy, Fiona, Flannery, John, Rajko-Nenow, Paulina, Powers, Claire, Wilson, Steve, Charleston, Bryan, Baron, Michael D., Batten, Carrie

“…A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV) has…”
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Transplacental transmission of bluetongue virus 8 in cattle, UK by Darpel, Karin E, Batten, Carrie A, Veronesi, Eva, Williamson, Susanna, Anderson, Peter, Dennison, Mike, Clifford, Stuart, Smith, Ciaran, Philips, Lucy, Bidewell, Cornelia, Bachanek-Bankowska, Katarzyna, Sanders, Anna, Bin-Tarif, Abid, Wilson, Anthony J, Gubbins, Simon, Mertens, Peter P C, Oura, Chris A, Mellor, Philip S

“…To determine whether transplacental transmission could explain overwintering of bluetongue virus in the United Kingdom, we studied calves born to dams…”
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Saliva proteins of vector Culicoides modify structure and infectivity of bluetongue virus particles by Darpel, Karin E, Langner, Kathrin F A, Nimtz, Manfred, Anthony, Simon J, Brownlie, Joe, Takamatsu, Haru-Hisa, Mellor, Philip S, Mertens, Peter P C

“…Bluetongue virus (BTV) and epizootic haemorrhagic disease virus (EHDV) are related orbiviruses, transmitted between their ruminant hosts primarily by certain…”
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Involvement of the skin during bluetongue virus infection and replication in the ruminant host by Darpel, Karin E, Monaghan, Paul, Simpson, Jennifer, Anthony, Simon J, Veronesi, Eva, Brooks, Harriet W, Elliott, Heather, Brownlie, Joe, Takamatsu, Haru-Hisa, Mellor, Philip S, Mertens, Peter Pc

“…Bluetongue virus (BTV) is a double stranded (ds) RNA virus (genus Orbivirus; family Reoviridae), which is considered capable of infecting all species of…”
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Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks by Sanz-Bernardo, Beatriz, Haga, Ismar R, Wijesiriwardana, Najith, Basu, Sanjay, Larner, Will, Diaz, Adriana V, Langlands, Zoë, Denison, Eric, Stoner, Joanne, White, Mia, Sanders, Christopher, Hawes, Philippa C, Wilson, Anthony J, Atkinson, John, Batten, Carrie, Alphey, Luke, Darpel, Karin E, Gubbins, Simon, Beard, Philippa M

“…Lumpy skin disease virus (LSDV) is a vector-transmitted poxvirus that causes disease in cattle. Vector species involved in LSDV transmission and their ability…”
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Purification of Epizootic Hemorrhagic Disease Virus (and Other Orbiviruses) Particles from Infected Mammalian or Insect Cells by Guimerà Busquets, Marc, Darpel, Karin E

“…Epizootic hemorrhagic disease virus (EHDV), like other orbiviruses, infects and replicates in mammalian and insect vector cells. Within its ruminant hosts…”
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Comparison of the Immunogenicities and Cross-Lineage Efficacies of Live Attenuated Peste des Petits Ruminants Virus Vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96 by Hodgson, Sophia, Moffat, Katy, Hill, Holly, Flannery, John T, Graham, Simon P, Baron, Michael D, Darpel, Karin E

“…Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East, and Asia. Several effective vaccines…”
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The Acquisition and Retention of Lumpy Skin Disease Virus by Blood-Feeding Insects Is Influenced by the Source of Virus, the Insect Body Part, and the Time since Feeding by Sanz-Bernardo, Beatriz, Suckoo, Rey, Haga, Ismar R, Wijesiriwardana, Najith, Harvey, Alice, Basu, Sanjay, Larner, Will, Rooney, Sara, Sy, Victoria, Langlands, Zoë, Denison, Eric, Sanders, Christopher, Atkinson, John, Batten, Carrie, Alphey, Luke, Darpel, Karin E, Gubbins, Simon, Beard, Philippa M

“…Lumpy skin disease virus (LSDV) is a poxvirus that causes severe systemic disease in cattle and is spread by mechanical arthropod-borne transmission. This…”
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Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection by Sanz-Bernardo, Beatriz, Haga, Ismar R., Wijesiriwardana, Najith, Hawes, Philippa C., Simpson, Jennifer, Morrison, Linda R., MacIntyre, Neil, Brocchi, Emiliana, Atkinson, John, Haegeman, Andy, De Clercq, Kris, Darpel, Karin E., Beard, Philippa M.

“…Lumpy skin disease is a high-consequence disease in cattle caused by infection with the poxvirus lumpy skin disease virus (LSDV). The virus is endemic in most…”
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Depletion of CD8+ T cells from vaccinated goats does not affect protection from challenge with wild‐type peste des petits ruminants virus by Baron, Michael D., Hodgson, Sophia, Moffat, Katy, Qureshi, Mehnaz, Graham, Simon P., Darpel, Karin E.

“…Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East and Asia. The disease is caused by peste…”
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Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts by Darpel, Karin E., Barber, James, Hope, Andrew, Wilson, Anthony J., Gubbins, Simon, Henstock, Mark, Frost, Lorraine, Batten, Carrie, Veronesi, Eva, Moffat, Katy, Carpenter, Simon, Oura, Chris, Mellor, Philip S., Mertens, Peter P. C.

“…Bluetongue virus (BTV) is an economically important arbovirus of ruminants that is transmitted by Culicoides spp . biting midges. BTV infection of ruminants…”
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Viraemia and clinical disease in Dorset Poll sheep following vaccination with live attenuated bluetongue virus vaccines serotypes 16 and 4 by Veronesi, Eva, Darpel, Karin E, Hamblin, Chris, Carpenter, Simon, Takamatsu, Haru-Hisa, Anthony, Simon J, Elliott, Heather, Mertens, Peter P.C, Mellor, Philip S

“…Abstract The spread of bluetongue virus (BTV) is most successfully controlled by vaccination of susceptible ruminant populations. Currently two different types…”
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