Search Results - "Darnell, Stephen"

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae by Leduc, Isabelle, Connolly, Kristie L, Begum, Afrin, Underwood, Knashka, Darnell, Stephen, Shafer, William M, Balthazar, Jacqueline T, Macintyre, Andrew N, Sempowski, Gregory D, Duncan, Joseph A, Little, Marguerite B, Rahman, Nazia, Garges, Eric C, Jerse, Ann E

“…There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of…”
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Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model by Broder, Kieran C., Matrosova, Vera Y., Tkavc, Rok, Gaidamakova, Elena K., Ho, Lam Thuy Vi Tran, Macintyre, Andrew N., Soc, Anthony, Diallo, Aissata, Darnell, Stephen C., Bash, Sarah, Daly, Michael J., Jerse, Ann E., Liechti, George W.

“…Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed,…”
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Bacillus anthracis Exosporium Protein BclA Affects Spore Germination, Interaction with Extracellular Matrix Proteins, and Hydrophobicity by Brahmbhatt, Trupti N, Janes, Brian K, Stibitz, E. Scott, Darnell, Stephen C, Sanz, Patrick, Rasmussen, Susan B, O'Brien, Alison D

“…Bacillus collagen-like protein of anthracis (BclA) is the immunodominant glycoprotein on the exosporium of Bacillus anthracis spores. Here, we sought to assess…”
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Detection of Bacillus anthracis Spore Germination In Vivo by Bioluminescence Imaging by Sanz, Patrick, Teel, Louise D, Alem, Farhang, Carvalho, Humberto M, Darnell, Stephen C, O'Brien, Alison D

“…We sought to visualize the site of Bacillus anthracis spore germination in vivo. For that purpose, we constructed a reporter plasmid with the lux operon under…”
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Recombinant Exosporium Protein BclA of Bacillus anthracis Is Effective as a Booster for Mice Primed with Suboptimal Amounts of Protective Antigen by Brahmbhatt, Trupti N, Darnell, Stephen C, Carvalho, Humberto M, Sanz, Patrick, Kang, Tae J, Bull, Robert L, Rasmussen, Susan B, Cross, Alan S, O'Brien, Alison D

“…Bacillus collagen-like protein of anthracis (BclA) is an immunodominant glycoprotein located on the exosporium of Bacillus anthracis. We hypothesized that…”
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Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis by Schmitt, C K, Ikeda, J S, Darnell, S C, Watson, P R, Bispham, J, Wallis, T S, Weinstein, D L, Metcalf, E S, O'Brien, A D

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Ferrets as a Model System for Renal Disease Secondary to Intestinal Infection with Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli by Woods, Jon B., Schmitt, Clare K., Darnell, Stephen C., Meysick, Karen C., O'Brien, Alison D.

“…Ferrets were evaluated as a possible small animal model for the development of colitis and/or signs of the hemolytic uremic syndrome after oral infection with…”
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A novel gonorrhea vaccine composed of MetQ lipoprotein formulated with CpG shortens experimental murine infection by Sikora, Aleksandra E., Gomez, Carolina, Le Van, Adriana, Baarda, Benjamin I., Darnell, Stephen, Martinez, Fabian G., Zielke, Ryszard A., Bonventre, Josephine A., Jerse, Ann E.

“…Bacterial surface lipoproteins are emerging as attractive vaccine candidates due to their biological importance and the feasibility of their large-scale…”
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The attenuated phenotype of a Salmonella typhimurium flgM mutant is related to expression of FliC flagellin by Schmitt, C K, Darnell, S C, O'Brien, A D

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The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species by Schmitt, Clare K, Darnell, Stephen C, O'Brien, Alison D

“…FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium. In recent experiments, we observed…”
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A Comprehensive Assessment of Barriers Encountered by Undocumented Hispanic Immigrants in Utilizing the U.S. Legal System by Darnell, Stephen Riley

“…This dissertation summarizes 22 months of field research beginning February 2015 and ending October 2016 among Nashville's undocumented Hispanic community. The…”
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The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species by Schmitt, Clare K., Darnell, Stephen C., O'Brien, Alison D.

“…Abstract FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium. In recent experiments, we…”
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Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis by Ikeda, J S, Schmitt, C K, Darnell, S C, Watson, P R, Bispham, J, Wallis, T S, Weinstein, D L, Metcalf, E S, Adams, P, O'Connor, C D, O'Brien, A D

“…Although Salmonella enterica serovar Typhimurium can undergo phase variation to alternately express two different types of flagellin subunit proteins, FljB or…”
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Virulence of Shiga toxin-producing Escherichia coli (STEC) in orally-infected mice correlates with the type of toxin produced by the infecting strain by Melton-Celsa, A R, Rogers, J E, Schmitt, C K, Darnell, S C, O'Brien, A D

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Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice by Melton-Celsa, A.R. (Uniformed Services University of the Health Sciences, Bethesda, MD.), Darnell, S.C, O'Brien, A.D

“…The enterohemorrhagic Escherichia coli (EHEC) O91:H21 isolates B2F1 and H414-36/89 are virulent in an orally infected streptomycin- treated mouse model…”
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Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli 0157:H7 and other shiga toxin--producing E.coli by Woods, Jon B, Schmitt, Clare K, Darnell, Stephen C, Meysick, Karen C, O'Brien, Alison D

“…Ferrets were evaluated as a possible small animal model for the development of colitis and/or signs of the hemolytic uremic syndrome after oral infection with…”
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Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype by SCHMITT, C. K, DARNELL, S. C, TESH, V. L, STOCKER, B. A. D, O'BRIEN, A. D

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Plasma torch interaction with a melting substrate by Hill, Stephen Darnell

“…A model of a partially ionized, high pressure plasma in stagnation flow as it melts a nonhomogeneous solid encompasses both the analysis of the multi-fluid…”
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Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis by IKEDA, Jack S, SCHMITT, Clare K, O'BRIEN, Alison D, DARNELL, Stephen C, WATSON, Patricia R, BISPHAM, Jennifer, WALLIS, Timothy S, WEINSTEIN, Debra L, METCALF, Eleanor S, ADAMS, Phillip, O'CONNOR, C. David

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Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not InfluenceSalmonella-Induced Enteropathogenesis by Jack S. Ikeda, Clare K. Schmitt, Stephen C. Darnell, Patricia R. Watson, Jennifer Bispham, Timothy S. Wallis, Debra L. Weinstein, Eleanor S. Metcalf, Phillip Adams, C. David O'Connor, Alison D. O'Brien

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