Search Results - "Darlington, Gretchen J."

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal by Sun, Deqiang, Luo, Min, Jeong, Mira, Rodriguez, Benjamin, Xia, Zheng, Hannah, Rebecca, Wang, Hui, Le, Thuc, Faull, Kym F., Chen, Rui, Gu, Hongcang, Bock, Christoph, Meissner, Alexander, Göttgens, Berthold, Darlington, Gretchen J., Li, Wei, Goodell, Margaret A.

“…To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a comprehensive integrated…”
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Long Non-Coding RNAs Control Hematopoietic Stem Cell Function by Luo, Min, Jeong, Mira, Sun, Deqiang, Park, Hyun Jung, Rodriguez, Benjamin A.T., Xia, Zheng, Yang, Liubin, Zhang, Xiaotian, Sheng, Kuanwei, Darlington, Gretchen J., Li, Wei, Goodell, Margaret A.

“…Hematopoietic stem cells (HSCs) possess unique gene expression programs that enforce their identity and regulate lineage commitment. Long non-coding RNAs…”
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Large conserved domains of low DNA methylation maintained by Dnmt3a by Jeong, Mira, Sun, Deqiang, Luo, Min, Huang, Yun, Challen, Grant A, Rodriguez, Benjamin, Zhang, Xiaotian, Chavez, Lukas, Wang, Hui, Hannah, Rebecca, Kim, Sang-Bae, Yang, Liubin, Ko, Myunggon, Chen, Rui, Göttgens, Berthold, Lee, Ju-Seog, Gunaratne, Preethi, Godley, Lucy A, Darlington, Gretchen J, Rao, Anjana, Li, Wei, Goodell, Margaret A

“…Margaret Goodell and colleagues report genome-wide mapping of 5-methylcytosine and 5-hydroxymethylcytosine in purified mouse hematopoietic stem cells. They…”
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Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice by McClellan, Andrew J, Volpe, Eugene A, Zhang, Xiaobo, Darlington, Gretchen J, Li, De-Quan, Pflugfelder, Stephen C, de Paiva, Cintia S

“…Dry eye in humans displays increased prevalence in the aged and in women. Here, we investigated the ocular surfaces and lacrimal glands of aged mice of both…”
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Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells by Challen, Grant A., Sun, Deqiang, Mayle, Allison, Jeong, Mira, Luo, Min, Rodriguez, Benjamin, Mallaney, Cates, Celik, Hamza, Yang, Liubin, Xia, Zheng, Cullen, Sean, Berg, Jonathan, Zheng, Yayun, Darlington, Gretchen J., Li, Wei, Goodell, Margaret A.

“…Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of blood and bone marrow. Recently, we reported that loss of de novo DNA…”
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CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells by Qiu, Qiong, Hernandez, Julio Cesar, Dean, Adam M, Rao, Pulivarthi H, Darlington, Gretchen J

“…The identification of specific cell surface markers that can be used to isolate liver progenitor cells will greatly facilitate experimentation to determine the…”
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Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver by Singh, Pallavi, Goode, Triona, Dean, Adam, Awad, Samir S, Darlington, Gretchen J

“…Our previous study on immune-related changes in the aged liver described immune cell infiltration and elevation of inflammation with age. Levels of interferon…”
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Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice by Kurinna, Svitlana, Stratton, Sabrina A., Tsai, Wen‐Wei, Akdemir, Kadir C., Gu, Weisong, Singh, Pallavi, Goode, Triona, Darlington, Gretchen J., Barton, Michelle Craig

“…The p53 family of proteins regulates the expression of target genes that promote cell cycle arrest and apoptosis, which may be linked to cellular growth…”
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Absence of Granulocyte Colony-Stimulating Factor Signaling and Neutrophil Development in CCAAT Enhancer Binding Protein α -deficient Mice by Zhang, Dong-Er, Zhang, Pu, Wang, Nai-Dy, Hetherington, Christopher J., Darlington, Gretchen J., Tenen, Daniel G.

“…Transcription factors are master regulatory switches of differentiation, including the development of specific hematopoietic lineages from stem cells. Here we…”
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Dnmt3a is essential for hematopoietic stem cell differentiation by Challen, Grant A, Sun, Deqiang, Jeong, Mira, Luo, Min, Jelinek, Jaroslav, Berg, Jonathan S, Bock, Christoph, Vasanthakumar, Aparna, Gu, Hongcang, Xi, Yuanxin, Liang, Shoudan, Lu, Yue, Darlington, Gretchen J, Meissner, Alexander, Issa, Jean-Pierre J, Godley, Lucy A, Li, Wei, Goodell, Margaret A

“…Margaret Goodell, Wei Li and colleagues report conditional ablation of the Dnmt3a DNA methyltransferase in hematopoietic stem cells (HSCs) in mice. They show…”
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Transcriptional Profiling of Bipotential Embryonic Liver Cells to Identify Liver Progenitor Cell Surface Markers by Ochsner, Scott A., Strick‐Marchand, Hélène, Qiu, Qiong, Venable, Susan, Dean, Adam, Wilde, Margaret, Weiss, Mary C., Darlington, Gretchen J.

“…The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic…”
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A Transcriptomic Signature of Mouse Liver Progenitor Cells by Finch-Edmondson, Megan, Zhu, Cornelia, Whelan, James, Callus, Bernard A., Yeoh, George C. T., Darlington, Gretchen J., Strick-Marchand, Helene, Tanaka, Minoru, Miyajima, Atsushi, Tirnitz-Parker, Janina E. E., London, Roslyn, Low, Jasmine, Passman, Adam M., Ochsner, Scott

“…Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration…”
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The Age-Associated Decline of Glycogen Synthase Kinase 3β Plays a Critical Role in the Inhibition of Liver Regeneration by Jin, Jingling, Wang, Guo-Li, Shi, Xiurong, Darlington, Gretchen J., Timchenko, Nikolai A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity by Wu, Zhidan, Rosen, Evan D, Brun, Regina, Hauser, Stefanie, Adelmant, Guillaume, Troy, Amy E, McKeon, Catherine, Darlington, Gretchen J, Spiegelman, Bruce M

“…Mice deficient in C/EBPα have defective development of adipose tissue, but the precise role of C/EBPα has not been defined. Fibroblasts from C/EBPα(−/−) mice…”
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The Role of C/EBP Genes in Adipocyte Differentiation by Darlington, Gretchen J., Ross, Sarah E., MacDougald, Ormond A.

“…One of the central problems facing higher animals is that cells require a continuous source of energy; however, it is impractical for organisms to meet this…”
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Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging by Lee, Janice S., Ward, William O., Ren, Hongzu, Vallanat, Beena, Darlington, Gretchen J., Han, Eun-Soo, Laguna, Juan C., DeFord, James H., Papaconstantinou, John, Selman, Colin, Corton, J. Christopher

“…► A meta-analysis was conducted on aging mouse liver gene expression profiles. ► Little overlap across studies in number of genes or canonical pathways…”
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Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice by Jiang, Yanjun, Jin, Jingling, Iakova, Polina, Hernandez, Julio Cesar, Jawanmardi, Nicole, Sullivan, Emily, Guo, Grace L., Timchenko, Nikolai A., Darlington, Gretchen J.

“…•Expression and activity of FXR is increased in Little mice.•Growth hormone treatment reversed alteration of FXR expression in Little mice.•Xenobiotic…”
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C/EBPα is Required for Differentiation of White, but not Brown, Adipose Tissue by Linhart, Heinz G., Ishimura-Oka, Kazumi, DeMayo, Franco, Kibe, Tetsuya, Repka, David, Poindexter, Brian, Bick, Roger J., Darlington, Gretchen J.

“…The transcription factor CCAAT enhancer binding protein α (C/EBPα) is expressed at high levels in liver and adipose tissue. Cell culture studies show that…”
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Direct Activation of Forkhead Box 03 by Tumor Suppressors p53 and p73 Is Disrupted During Liver Regeneration in Mice by KURINNA, Svitlana, STRATTON, Sabrina A, TSAI, Wen-Wei, AKDEMIR, Kadir C, WEISONG GU, SINGH, Pallavi, GOODE, Triona, DARLINGTON, Gretchen J, BARTON, Michelle Craig

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Metabolic Response of Mice to a Postnatal Ablation of CCAAT/Enhancer-binding Protein α by Yang, Jianqi, Croniger, Colleen M., Lekstrom-Himes, Julie, Zhang, Pu, Fenyus, Maris, Tenen, Daniel G., Darlington, Gretchen J., Hanson, Richard W.

“…Although CCAAT/enhancer-binding protein α (C/EBPα) is essential for initiating or sustaining several metabolic processes during the perinatal period, the…”
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