Search Results - "Darland, Diane C."

Nanozymes-Hitting the Biosensing "Target" by Wu, Yingfen, Darland, Diane C, Zhao, Julia Xiaojun

“…Nanozymes are a class of artificial enzymes that have dimensions in the nanometer range and can be composed of simple metal and metal oxide nanoparticles,…”
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Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors by Saint-Geniez, Magali, Maharaj, Arindel S R, Walshe, Tony E, Tucker, Budd A, Sekiyama, Eiichi, Kurihara, Tomoki, Darland, Diane C, Young, Michael J, D'Amore, Patricia A

“…Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates…”
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Development of alveolar-capillary-exchange (ACE) chip and its application for assessment of PM2.5-induced toxicity by Guan, Mingyang, Tang, Song, Chang, Huiyun, Chen, Yuanyuan, Chen, Fengge, Mu, Ying, Zhao, Dong, Fan, Weiwei, Tian, Huifang, Darland, Diane C., Zhang, Ying

“…Although standard two-dimensional (2D) cell culture is an effective tool for cell studies, monolayer cultivation can yield imperfect or misleading information…”
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The Hox protein conundrum: The “specifics” of DNA binding for Hox proteins and their partners by De Kumar, Bony, Darland, Diane C.

“…Homeotic genes (Hox genes) are homeodomain-transcription factors involved in conferring segmental identity along the anterior-posterior body axis. Molecular…”
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Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish by Mersereau, Eric J, Boyle, Cody A, Poitra, Shelby, Espinoza, Ana, Seiler, Joclyn, Longie, Robert, Delvo, Lisa, Szarkowski, Megan, Maliske, Joshua, Chalmers, Sarah, Darland, Diane C, Darland, Tristan

“…A sizeable portion of the societal drain from cocaine abuse results from the complications of in utero drug exposure. Because of challenges in using humans and…”
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Effects of Probiotic Supplementation on Short Chain Fatty Acids in the AppNL-G-F Mouse Model of Alzheimer's Disease by Kaur, Harpreet, Golovko, Svetlana, Golovko, Mikhail Y, Singh, Surjeet, Darland, Diane C, Combs, Colin K

“…The intestinal microbiota and its metabolites, particularly short-chain fatty acids (SCFAs), have been implicated in immune function, host metabolism, and even…”
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Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation by Ding, Rubai, Darland, Diane C, Parmacek, Michael S, D'Amore, Patricia A

“…Cell-cell interactions are central to vascular development. We have developed an in vitro system in which endothelial cells (EC) are co-cultured with 10T1/2…”
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Streamlined synthesis of potential dual-emissive fluorescent silicon quantum dots (SiQDs) for cell imaging by Sun, Di, Wu, Steven, Martin, Jeremy P, Tayutivutikul, Kirati, Du, Guodong, Combs, Colin, Darland, Diane C, Zhao, Julia Xiaojun

“…One of the current challenges of working with nanomaterials in bioapplications is having a tool that is biocompatible (non-toxic) and produces stable, intense…”
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Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy by Schultz, Anastasia, Albertos‐Arranz, Henar, Sáez, Xavier Sánchez, Morgan, Jamie, Darland, Diane C., Gonzalez‐Duarte, Alejandra, Kaufmann, Horacio, Mendoza‐Santiesteban, Carlos E., Cuenca, Nicolás, Lefcort, Frances

“…Familial dysautonomia (FD) is a rare genetic neurodevelopmental and neurodegenerative disorder. In addition to the autonomic and peripheral sensory…”
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The longitudinal effects of early developmental cadmium exposure on conditioned place preference and cardiovascular physiology in zebrafish by Wold, Marissa, Beckmann, Myranda, Poitra, Shelby, Espinoza, Ana, Longie, Robert, Mersereau, Erik, Darland, Diane C., Darland, Tristan

“…•Developmental exposure to Cd significantly decreased body, eye, and brain size but increased heart rate of 5dpf larvae.•Longitudinal survival of fish treated…”
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Postnatal exercise protects offspring from high-fat diet-induced reductions in subcutaneous adipocyte beiging in C57Bl6/J mice by Claycombe-Larson, Kate J., Bundy, Amy, Lance, Elizabeth Black, Darland, Diane C., Casperson, Shanon L., Roemmich, James N.

“…Maternal low-protein and postnatal high-fat (HF) diets program offspring obesity and type 2 diabetes mellitus (T2DM) risk by epigenetically reducing beige…”
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Loss of Slfn3 induces a sex-dependent repair vulnerability after 50% bowel resection by Vomhof-DeKrey, Emilie E, Lansing, Jack T, Darland, Diane C, Umthun, Josey, Stover, Allie D, Brown, Christopher, Basson, Marc D

“…Bowel resection accelerates enterocyte proliferation in the remaining gut with suboptimal absorptive and digestive capacity because of a…”
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APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease by Manocha, Gunjan D, Floden, Angela M, Rausch, Keiko, Kulas, Joshua A, McGregor, Brett A, Rojanathammanee, Lalida, Puig, Kelley R, Puig, Kendra L, Karki, Sanjib, Nichols, Michael R, Darland, Diane C, Porter, James E, Combs, Colin K

“…Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia…”
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Engineering vascularized skeletal muscle tissue by Levenberg, Shulamit, Langer, Robert, Rouwkema, Jeroen, Macdonald, Mara, Garfein, Evan S, Kohane, Daniel S, Darland, Diane C, Marini, Robert, van Blitterswijk, Clemens A, Mulligan, Richard C, D'Amore, Patricia A

“…One of the major obstacles in engineering thick, complex tissues such as muscle is the need to vascularize the tissue in vitro. Vascularization in vitro could…”
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Long-term retention of knowledge and critical thinking skills in developmental biology by Darland, Diane C, Carmichael, Jeffrey S

“…The primary goal of this project was to assess long-term retention of concepts and critical thinking skills in individuals who completed a Developmental…”
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Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations by MORRIS, Paul N, DUNMORE, Benjamin J, TADROS, Amir, MARCHUK, Douglas A, DARLAND, Diane C, D'AMORE, Patricia A, BRINDLE, Nicholas P. J

“…Tie2 is expressed predominantly in endothelial cells and is required for blood vessel formation and maintenance. A missense mutation resulting in an R to W…”
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Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1α in zebrafish by Darland, Tristan, Mauch, Justin T., Meier, Ellen M., Hagan, Shannon J., Dowling, John E., Darland, Diane C.

“…Finding genetic polymorphisms and mutations linked to addictive behavior can provide important targets for pharmaceutical and therapeutic interventions…”
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Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development by Darland, Diane C., Cain, Jacob T., Berosik, Matthew A., Saint-Geniez, Magali, Odens, Patrick W., Schaubhut, Geoffrey J., Frisch, Sarah, Stemmer-Rachamimov, Anat, Darland, Tristan, D'Amore, Patricia A.

“…This work was designed to determine the role of the vascular endothelial growth factor A (VEGF) isoforms during early neuroepithelial development in the…”
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Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain by Cain, Jacob T., Berosik, Matthew A., Snyder, Stephanie D., Crawford, Natalie F., Nour, Shirin I., Schaubhut, Geoffrey J., Darland, Diane C.

“…ABSTRACT Regulation of neural stem cell (NSC) fate decisions is critical during the transition from a multicellular mammalian forebrain neuroepithelium to the…”
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CADASIL mutations impair Notch3 glycosylation by Fringe by Arboleda-Velasquez, Joseph F., Rampal, Raajit, Fung, Erik, Darland, Diane C., Liu, Min, Martinez, Maria C., Donahue, Christine P., Navarro-Gonzalez, Manuel F., Libby, Peter, D'Amore, Patricia A., Aikawa, Masanori, Haltiwanger, Robert S., Kosik, Kenneth S.

“…Mutations in the NOTCH3 gene trigger adult-onset stroke and vascular dementia in patients with CADASIL (cerebral autosomal dominant arteriopathy with…”
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