Search Results - "Dark, Michael J"

Deep learning for necrosis detection using canine perivascular wall tumour whole slide images by Rai, Taranpreet, Morisi, Ambra, Bacci, Barbara, Bacon, Nicholas J., Dark, Michael J., Aboellail, Tawfik, Thomas, Spencer Angus, Bober, Miroslaw, La Ragione, Roberto, Wells, Kevin

“…Necrosis seen in histopathology Whole Slide Images is a major criterion that contributes towards scoring tumour grade which then determines treatment options…”
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International Guidelines for Veterinary Tumor Pathology: A Call to Action by Meuten, Donald J., Moore, Frances M., Donovan, Taryn A., Bertram, Christof A., Klopfleisch, Robert, Foster, Robert A., Smedley, Rebecca C., Dark, Michael J., Milovancev, Milan, Stromberg, Paul, Williams, Bruce H., Aubreville, Marc, Avallone, Giancarlo, Bolfa, Pompei, Cullen, John, Dennis, Michelle M., Goldschmidt, Michael, Luong, Richard, Miller, Andrew D., Miller, Margaret A., Munday, John S., Roccabianca, Paola, Salas, Elisa N., Schulman, F. Yvonne, Laufer-Amorim, Renee, Asakawa, Midori G., Craig, Linden, Dervisis, Nick, Esplin, D. Glen, George, Jeanne W., Hauck, Marlene, Kagawa, Yumiko, Kiupel, Matti, Linder, Keith, Meichner, Kristina, Marconato, Laura, Oblak, Michelle L., Santos, Renato L., Simpson, R. Mark, Tvedten, Harold, Whitley, Derick

“…Standardization of tumor assessment lays the foundation for validation of grading systems, permits reproducibility of oncologic studies among investigators,…”
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RNA in situ hybridisation as a molecular diagnostic technique targeting IBA‐1 and CD204 in canine histiocytic sarcoma by Engelien, Julia L, Lejeune, Amandine T, Dark, Michael J, Milner, Rowan J, Shiomitsu, Keijiro

“…Background Canine histiocytic sarcoma (HS) is an aggressive cancer with morphologically variable features; therefore, obtaining a definitive diagnosis can be…”
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Detection of Necrosis in Digitised Whole-Slide Images for Better Grading of Canine Soft-Tissue Sarcomas Using Machine-Learning by Morisi, Ambra, Rai, Taran, Bacon, Nicholas J, Thomas, Spencer A, Bober, Miroslaw, Wells, Kevin, Dark, Michael J, Aboellail, Tawfik, Bacci, Barbara, La Ragione, Roberto M

“…The definitive diagnosis of canine soft-tissue sarcomas (STSs) is based on histological assessment of formalin-fixed tissues. Assessment of parameters, such as…”
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Multiple biliary duct hamartomas in a cat resulting in a hepatic mass: A case report by Naghi, Rachel, Bertran, Judith, Spoldi, Elisa, Dark, Michael J, de Oliveira, Helena Hauck, Souza, Carlos, Maxwell, Elizabeth A

“…A 13-year-old, male neutered domestic short-haired cat was diagnosed with multiple biliary duct hamartomas after liver lobectomy for a suspected malignant…”
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Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins by Brayton, K.A, Kappmeyer, L.S, Herndon, D.R, Dark, M.J, Tibbals, D.L, Palmer, G.H, McGuire, T.C, Knowles, D.P. Jr

“…The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale…”
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SDHB and SDHA Immunohistochemistry in Canine Pheochromocytomas by Abed, Firas M, Brown, Melissa A, Al-Mahmood, Omar A, Dark, Michael J

“…Pheochromocytomas (PCs) are tumors arising from the chromaffin cells of the adrenal glands and are the most common tumors of the adrenal medulla in animals. In…”
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Superinfection as a driver of genomic diversification in antigenically variant pathogens by Futse, James E, Brayton, Kelly A, Dark, Michael J, Knowles, Donald P. Jr, Palmer, Guy H

“…A new pathogen strain can penetrate an immune host population only if it can escape immunity generated against the original strain. This model is best…”
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Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility by Glahn, Imaine, Haghofer, Andreas, Donovan, Taryn A, Degasperi, Brigitte, Bartel, Alexander, Kreilmeier-Berger, Theresa, Hyndman, Philip S, Janout, Hannah, Assenmacher, Charles-Antoine, Bartenschlager, Florian, Bolfa, Pompei, Dark, Michael J, Klang, Andrea, Klopfleisch, Robert, Merz, Sophie, Richter, Barbara, Schulman, F Yvonne, Ganz, Jonathan, Scharinger, Josef, Aubreville, Marc, Winkler, Stephan M, Bertram, Christof A

“…The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various…”
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Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model by Watson Levings, Rachael S, Broome, Ted A, Smith, Andrew D, Rice, Brett L, Gibbs, Eric P, Myara, David A, Hyddmark, E Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P, Lu, Yuan, White, Margaret E, Dacanay, E Anthony, Foremny, Gregory B, Evans, Christopher H, Morton, Alison J, Winter, Mathew, Dark, Michael J, Nickerson, David M, Colahan, Patrick T, Ghivizzani, Steven C

“…Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery…”
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Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses by Sahay, Bikash, Aranyos, Alek M, Mishra, Meerambika, McAvoy, Andrew C, Martin, Marcus M, Pu, Riuyu, Shiomitsu, Sayaka, Shiomitsu, Keijiro, Dark, Michael J, Sanou, Missa P, Roff, Shannon R, Rathore, Mobeen H, Yamamoto, Janet K

“…For the development of an effective HIV-1 vaccine, evolutionarily conserved epitopes between feline and human immunodeficiency viruses (FIV and HIV-1) were…”
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Evaluation of the effect of formalin fixation on skin specimens in dogs and cats by Miller, Jaimie L, Dark, Michael J

“…Skin and subcutaneous tissues are the origin of most common neoplasms affecting dogs, accounting for approximately one third of all tumors encountered in the…”
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Determining the repertoire of immunodominant proteins via whole-genome amplification of intracellular pathogens by Dark, Michael J, Lundgren, Anna M, Barbet, Anthony F

“…Culturing many obligate intracellular bacteria is difficult or impossible. However, these organisms have numerous adaptations allowing for infection…”
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Determining the utility of veterinary tissue archives for retrospective DNA analysis by Abed, Firas M, Dark, Michael J

“…Histopathology tissue archives can be an important source of specimens for retrospective studies, as these include samples covering a large number of diseases…”
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Complete Urogenital and Anorectal Duplication in a Dog by Huynh, Elizabeth, Ellison, Gary, McConkey, Marina, Coffman, Jonathan M., Dark, Michael J.

“…A 10-week-old sexually intact female golden retriever was evaluated for two functional anal openings and a bipartite vulva. Examination revealed haired skin…”
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Immunogenicity of Anaplasma marginale Type IV Secretion System Proteins in a Protective Outer Membrane Vaccine by Lopez, Job E, Palmer, Guy H, Brayton, Kelly A, Dark, Michael J, Leach, Stephanie E, Brown, Wendy C

“…Rickettsial pathogens in the genera Anaplasma and Ehrlichia cause acute infection in immunologically naive hosts and are major causes of tick-borne disease in…”
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Comparative genomics and transcriptomics of trait-gene association by Pierlé, Sebastián Aguilar, Dark, Michael J, Dahmen, Dani, Palmer, Guy H, Brayton, Kelly A

“…The Order Rickettsiales includes important tick-borne pathogens, from Rickettsia rickettsii, which causes Rocky Mountain spotted fever, to Anaplasma marginale,…”
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Conservation in the face of diversity: multistrain analysis of an intracellular bacterium by Dark, Michael J, Herndon, David R, Kappmeyer, Lowell S, Gonzales, Mikel P, Nordeen, Elizabeth, Palmer, Guy H, Knowles, Jr, Donald P, Brayton, Kelly A

“…With the recent completion of numerous sequenced bacterial genomes, notable advances have been made in understanding the level of conservation between various…”
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Comparison of histomorphology and DNA preservation produced by fixatives in the veterinary diagnostic laboratory setting by Craft, William F, Conway, Julia A, Dark, Michael J

“…Histopathology is the most useful tool for diagnosis of a number of diseases, especially cancer. To be effective, histopathology requires that tissues be fixed…”
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Viral Enrichment Methods Affect the Detection but Not Sequence Variation of West Nile Virus in Equine Brain Tissue by Prakoso, Dhani, Dark, Michael J, Barbet, Anthony F, Salemi, Marco, Barr, Kelli L, Liu, Junjie J, Wenzlow, Nanny, Waltzek, Thomas B, Long, Maureen T

“…West Nile virus (WNV), a small, positive sense, single stranded RNA virus continues to encroach into new locales with emergence of new viral variants…”
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