Search Results - "Dark, Callum"

The role of ADHD associated genes in neurodevelopment by Dark, Callum, Homman-Ludiye, Jihane, Bryson-Richardson, Robert J.

“…Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood. It is primarily characterised by high levels of…”
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The role of cadherin genes in five major psychiatric disorders: A literature update by Hawi, Ziarih, Tong, Janette, Dark, Callum, Yates, Hannah, Johnson, Beth, Bellgrove, Mark A.

“…Converging evidence from candidate gene, genome‐wide linkage, and association studies support a role of cadherins in the pathophysiology of five major…”
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Functional validation of CHMP7 as an ADHD risk gene by Dark, Callum, Williams, Caitlin, Bellgrove, Mark A., Hawi, Ziarih, Bryson-Richardson, Robert J.

“…Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder of childhood with a strong genetic component. Despite the success of mapping…”
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Analyzing cachectic phenotypes in the muscle and fat body of Drosophila larvae by Dark, Callum, Cheung, Shane, Cheng, Louise Y.

“…Drosophila has become a popular model for examining the metabolic wasting syndrome, cachexia, characterized by degradation of muscles and fat. Here we present…”
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Tumor-derived MMPs regulate cachexia in a Drosophila cancer model by Lodge, William, Zavortink, Michael, Golenkina, Sofia, Froldi, Francesca, Dark, Callum, Cheung, Shane, Parker, Benjamin L., Blazev, Ronnie, Bakopoulos, Daniel, Christie, Elizabeth L., Wimmer, Verena C., Duckworth, Brigette C., Richardson, Helena E., Cheng, Louise Y.

“…Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related mortalities. We have established a…”
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Convergent insulin and TGF‐β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model by Bakopoulos, Daniel, Golenkina, Sofya, Dark, Callum, Christie, Elizabeth L, Sánchez‐Sánchez, Besaiz J, Stramer, Brian M, Cheng, Louise Y

“…In this study, we found that in the adipose tissue of wildtype animals, insulin and TGF‐β signalling converge via a BMP antagonist short gastrulation (sog) to…”
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Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model by Dark, Callum, Ali, Nashia, Golenkina, Sofya, Dhyani, Vaibhav, Blazev, Ronnie, Parker, Benjamin L, Murphy, Kate T, Lynch, Gordon S, Senapati, Tarosi, Millard, S Sean, Judge, Sarah M, Judge, Andrew R, Giri, Lopamudra, Russell, Sarah M, Cheng, Louise Y

“…Cancer cachexia is a tumour-induced wasting syndrome, characterised by extreme loss of skeletal muscle. Defective mitochondria can contribute to muscle…”
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Functional validation of CHMP7 as an ADHD risk gene by Dark, Callum, Williams, Caitlin, Bellgrove, Mark A, Hawi, Ziarih, Bryson-Richardson, Robert J

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A case–control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene by Hawi, Ziarih, Yates, Hannah, Pinar, Ari, Arnatkeviciute, Aurina, Johnson, Beth, Tong, Janette, Pugsley, Kealan, Dark, Callum, Pauper, Marc, Klein, Marieke, Heussler, Helen S., Hiscock, Harriet, Fornito, Alex, Tiego, Jeggan, Finlay, Amy, Vance, Alasdair, Gill, Michael, Kent, Lindsey, Bellgrove, Mark A.

“…It is well-established that there is a strong genetic contribution to the aetiology of attention deficit hyperactivity disorder (ADHD). Here, we employed a…”
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