Distinctive roles of PKC delta isozyme in platelet function

Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it...

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Bibliographic Details
Published in:	Current research in translational medicine Vol. 64; no. 3; pp. 135 - 139
Main Authors:	Zaid, Y., Senhaji, N., Darif, Y., Kojok, K., Oudghiri, M., Naya, A.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-07-2016
Subjects:	PKC delta Platelets Thrombosis PKC delta Platelets Thrombosis
Online Access:	Get full text
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Summary:	Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function. Understanding the crucial role of PKCδ in platelet functions is recently emerging in the literature, therefore, further investigations should shed light into its specific role in hemostasis. In this review, we focus on the different roles of PKCδ in platelet activation, aggregation and thrombus formation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2452-3186 2452-3186
DOI:	10.1016/j.retram.2016.05.001