Search Results - "Darga, T."

SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine by Murley, J.S., Baker, K.L., Miller, R.C., Darga, T.E., Weichselbaum, R.R., Grdina, D.J.

“…Manganese superoxide dismutase (SOD2)-mediated adaptive processes that protect against radiation-induced micronucleus formation can be induced in cells after a…”
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A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation by Seiwert, T.Y., Darga, T., Haraf, D., Blair, E.A., Stenson, K., Cohen, E.E.W., Salama, J.K., Villaflor, V., Witt, M.E., Lingen, M.W., Weichselbaum, R.R., Vokes, E.E.

“…AdGV.EGR.TNF.11D (TNFerade™ Biologic) is a replication-deficient adenoviral vector expressing human tumor necrosis factor alpha (TNF-α) under the control of…”
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14q32-Encoded MicroRNAs Mediate Oligometastasis by Pitroda, S, Uppal, A, Wightman, S, Mallon, S, Oshima, G, Zhang, Q, Huang, X, Darga, T, Huang, L, Andrade, J, Liu, H, Ferguson, M.K, Greene, G, Posner, M, Hellman, S, Khodarev, N, Weichselbaum, R.R

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RIG-1-Like Receptor LGP2 Protects Tumor Cells From Ionizing Radiation by Pitroda, S, Widau, R, Parekh, A, Golden, D, Ranck, M, Sood, R, Huang, X, Darga, T, Roizman, B, Khodarev, N, Weichselbaum, R

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Statin Therapy for Prostate Cancer: Understudied and Underutilized by Gutt, R, Liauw, S.L, Beckett, M, Liang, H, Perakis, S, Filippo, M, Pitroda, S.P, Darga, T, Khodarev, N.N, Weichselbaum, R.R

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A Genomic Screening Based Strategy for the Creation of Radiation Inducible Gene Therapy Vectors by Advani, S.J, Khodarev, N.N, Darga, T, Weichselbaum, C, Beckett, M, Weichselbaum, R.R

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Translational strategies exploiting TNF-α that sensitize tumors to radiation therapy by Mauceri, H J, Beckett, M A, Liang, H, Sutton, H G, Pitroda, S, Galka, E, Efimova, E, Darga, T, Khodarev, N N, King, C R, Posner, M C, Hellman, S, Kufe, D W, Weichselbaum, R R

“…TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-α (TNF-α) (Ad.Egr-TNF) currently in a phase III trial for inoperable pancreatic…”
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Exploiting structure in symmetry detection for CNF by Darga, Paul T., Liffiton, Mark H., Sakallah, Karem A., Markov, Igor L.

“…Instances of the Boolean satisfiability problem (SAT) arise in many areas of circuit design and verification. These instances are typically constructed from…”
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STAT1 Is Overexpressed in Tumors Selected for Radioresistance and Confers Protection from Radiation in Transduced Sensitive Cells by Khodarev, Nikolai N., Beckett, Michael, Labay, Edwardine, Darga, Thomas, Roizman, Bernard, Weichselbaum, Ralph R.

“…Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude…”
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Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells by Khodarev, Nikolai N, Yu, Jianqing, Labay, Edwardine, Darga, Thomas, Brown, Charles K, Mauceri, Helena J, Yassari, Reza, Gupta, Nalin, Weichselbaum, Ralph R

“…Tumour angiogenesis is a complex process based upon a sequence of interactions between tumour cells and endothelial cells. To model tumour/endothelial-cell…”
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A phase I dose escalation study of Ad GV.EGR.TNF.11 D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation by SEIWERT, T. Y, DARGA, T, WEICHSELBAUM, R. R, VOKES, E. E, HARAF, D, BLAIR, E. A, STENSON, K, COHEN, E. E. W, SALAMA, J. K, VILLAFLOR, V, WITT, M. E, LINGEN, M. W

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Functional Implications of the Spectrum of Mutations Found in 234 Cases With X-linked Juvenile Retinoschisis (XLRS)

“…X-linked retinoschisis (XLRS) is the most common cause of juvenile macular degeneration in males, resulting in vision loss early in life. The gene involved in…”
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Translational strategies exploiting TNF-[alpha] that sensitize tumors to radiation therapy by Mauceri, H J, Beckett, M A, Liang, H, Sutton, H G, Pitroda, S, Galka, E, Efimova, E, Darga, T, Khodarev, N N, King, C R, Posner, M C, Hellman, S, Kufe, D W, Weichselbaum, R R

“…TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-alpha (TNF-alpha) (Ad.Egr-TNF) currently in a phase III trial for inoperable…”
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Endothelial cells co‐cultured with wild‐type and dominant/negative p53‐transfected glioblastoma cells exhibit differential sensitivity to radiation‐induced apoptosis by Khodarev, Nikolai N., Labay, Edwardine, Darga, Thomas, Yu, Jianqing, Mauceri, Helena, Gupta, Nalin, Kataoka, Yasushi, Weichselbaum, Ralph R.

“…We performed expressional profiling of isogenic glioblastoma cell lines U87‐Lux8 and U87‐175.4. These cell lines differ in that U87‐Lux8 expresses wild‐type…”
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Progression of barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation by KIMCHI, Erik T, POSNER, Mitchell C, KHODAREV, Nikolai N, PARK, James O, DARGA, Thomas E, KOCHERGINSKY, Masha, KARRISON, Theodore, HART, John, SMITH, Kerrington D, MEZHIR, James J, WEICHSELBAUM, Ralph R

“…We did expressional profiling on 24 paired samples of normal esophageal epithelium, Barrett's metaplasia, and esophageal adenocarcinomas. Matching tissue…”
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640 Stat1 as mediator of acquired tumor radioresistance and potential target for anti-tumor therapy by Khodarev, N.N., Labay, E., Beckett, M., Darga, T., Halpern, A., Roizman, B., Weichselbaum, R.R.

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Faster symmetry discovery using sparsity of symmetries by Darga, Paul T., Sakallah, Karem A., Markov, Igor L.

“…Many computational tools have recently begun to benefit from the use of the symmetry inherent in the tasks they solve, and use general-purpose graph symmetry…”
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Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses by MEZHIR, James J, ADVANI, Sunil J, SMITH, Kerrington D, DARGA, Thomas E, POON, Alice P. W, SCHMIDT, Hank, POSNER, Mitchell C, ROIZMAN, Bernard, WEICHSELBAUM, Ralph R

“…Ionizing radiation potentiates the oncolytic activity of attenuated herpes simplex viruses in tumors exposed to irradiation at specific time intervals by…”
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Glioblastoma cells block radiation-induced programmed cell death of endothelial cells by Brown, Charles K., Khodarev, Nikolai N., Yu, Jianqing, Moo-Young, Tricia, Labay, Edwardine, Darga, Thomas E., Posner, Mitchell C., Weichselbaum, Ralph R., Mauceri, Helena J.

“…We demonstrate that human umbilical vein endothelial cells (HUVEC) grown in co-culture (CC) with U87 glioblastoma cells transfected with green fluorescent…”
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Transcriptional control of viral gene therapy by cisplatin by Park, JO, Lopez, CA, Gupta, V K, Brown, C K, Mauceri, HJ, Darga, TE, Manan, A, Hellman, S, Posner, M C, Kufe, D W, Weichselbaum, R R

“…Ionizing radiation (IR) and radical oxygen intermediates (ROIs) activate the early growth response-1 (Egr1) promoter through specific cis-acting sequences…”
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