Search Results - "Darcy, P K"

Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models by Porter, L. H., Zhu, J. J., Lister, N. L., Harrison, S. G., Keerthikumar, S., Goode, D. L., Urban, R. Quezada, Byrne, D. J., Azad, A., Vela, I., Hofman, M. S., Neeson, P. J., Darcy, P. K., Trapani, J. A., Taylor, R. A., Risbridger, G. P.

“…Chimeric antigen receptor (CAR) T cells have transformed the treatment landscape for hematological malignancies. However, CAR T cells are less efficient…”
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Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma by Halse, H., Colebatch, A. J., Petrone, P., Henderson, M. A., Mills, J. K., Snow, H., Westwood, J. A., Sandhu, S., Raleigh, J. M., Behren, A., Cebon, J., Darcy, P. K., Kershaw, M. H., McArthur, G. A., Gyorki, D. E., Neeson, P. J.

“…A prospective study explored the heterogeneous nature of metastatic melanoma using Multiplex immunohistochemistry (IHC) and flow cytometry (FACS). Multiplex…”
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Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen by Peinert, S, Prince, H M, Guru, P M, Kershaw, M H, Smyth, M J, Trapani, J A, Gambell, P, Harrison, S, Scott, A M, Smyth, F E, Darcy, P K, Tainton, K, Neeson, P, Ritchie, D S, Hönemann, D

“…We have evaluated the carbohydrate antigen Lewis Y (Le Y ) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary…”
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Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids by VINCAN, E, DARCY, P. K, FARRELLY, C. A, FAUX, M. C, BRABLETZ, T, RAMSAY, R. G

“…Progression of colorectal cancer (CRC) involves spatial and temporal occurrences of epithelial-mesenchymal transition (EMT), whereby tumour cells acquire a…”
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Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity by Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D. S., Darcy, P. K., Neeson, P. J., Jenkins, M. R.

“…Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells…”
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Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype by Neeson, P, Shin, A, Tainton, K M, Guru, P, Prince, H M, Harrison, S J, Peinert, S, Smyth, M J, Trapani, J A, Kershaw, M H, Darcy, P K, Ritchie, D S

“…The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen…”
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Early-phenotype CAR-T cells for the treatment of pediatric cancers by Meyran, D., Terry, R.L., Zhu, J.J., Haber, M., Ziegler, D.S., Ekert, P.G., Trapani, J.A., Darcy, P.K., Neeson, P.J.

“…Chimeric antigen receptor (CAR)-T-cell therapy is a promising approach for the treatment of childhood cancers, particularly high-risk tumors that fail to…”
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Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux by Tainton, K M, Smyth, M J, Jackson, J T, Tanner, J E, Cerruti, L, Jane, S M, Darcy, P K, Johnstone, R W

“…P-glycoprotein (P-gp) can induce multidrug resistance (MDR) through the ATP-dependent efflux of chemotherapeutic agents. We have previously shown that P-gp can…”
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Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice by Westwood, J A, Murray, W K, Trivett, M, Shin, A, Neeson, P, MacGregor, D P, Haynes, N M, Trapani, J A, Mayura-Guru, P, Fox, S, Peinert, S, Honemann, D, Prince, H M, Ritchie, D, Scott, A M, Smyth, F E, Smyth, M J, Darcy, P K, Kershaw, M H

“…There is considerable concern regarding the transforming potential of retroviral vectors currently used for gene therapy, with evidence that retroviral…”
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Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma by Haynes, N M, Snook, M B, Trapani, J A, Cerruti, L, Jane, S M, Smyth, M J, Darcy, P K

“…The structurally related TCR-zeta and Fc receptor for IgE (Fc epsilon RI)-gamma are critical signaling components of the TCR and Fc epsilon RI, respectively…”
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P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation by Ruefli, A A, Tainton, K M, Darcy, P K, Smyth, M J, Johnstone, R W

“…Previous studies by our laboratory have shown that the drug transporter protein P-glycoprotein, P-gp, can specifically inhibit Fas-induced caspase-3 activation…”
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A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation by Ludford-Menting, Mandy J., Oliaro, Jane, Sacirbegovic, Faruk, Cheah, Eric T.-Y., Pedersen, Natalie, Thomas, Suzanne J., Pasam, Anupama, Iazzolino, Rosa, Dow, Lukas E., Waterhouse, Nigel J., Murphy, Amanda, Ellis, Sarah, Smyth, Mark J., Kershaw, Michael H., Darcy, Phillip K., Humbert, Patrick O., Russell, Sarah M.

“…T cell shape is dictated by the selective recruitment of molecules to different regions of the cell (polarity) and is integral to every aspect of T cell…”
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Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection by Smyth, Mark J, Kelly, Janice M, Darcy, Phillip K, Markby, Jessica L, Godfrey, Dale I, Takeda, Kazuyoshi, Yagita, Hideo

“…Natural killer (NK) cells may modulate the development of adaptive immune responses, but until now there has been little evidence to support this hypothesis…”
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Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells by Berry, L. J., Moeller, M., Darcy, P. K.

“…Adoptive cellular immunotherapy involving transfer of tumor‐reactive T cells has shown some notable antitumor responses in a minority of cancer patients. In…”
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Genetic analysis of Dictyostelium slug phototaxis mutants by Darcy, P.K, Wilczynska, Z, Fisher, P.R

“…Mapping and complementation analysis with 17 phototaxis mutations has established 11 complementation groups phoA-phoK distributed over six linkage groups…”
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Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2 by Xu, Y, Darcy, P K, Kershaw, M H

“…Dendritic cells (DC) perform an important role in the initiation of the immune response through the local secretion of inflammatory mediators within diseased…”
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Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes by HAYNES, N. M, SMYTH, M. J, KERSHAW, M. H, TRAPANI, J. A, DARCY, P. K

“…A chimeric receptor, consisting of the single-chain variable (scFv) domains of an anti-erbB-2 mAb linked via a CD8 membrane-proximal hinge to the Fc receptor…”
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The role of cGMP in photosensory and thermosensory transduction in Dictyostelium discoideum by DARCY, P. K, WILCZYNSKA, Z, FISHER, P. R

“…Microbiology Department, La Trobe University, Bundoora 3083, Melbourne, Australia Author for correspondence: P. R. Fisher. Tel: +61 3 479 2496. Fax: +61 3 479…”
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Gene Modification Strategies to Induce Tumor Immunity by Murphy, Amanda, Westwood, Jennifer A., Teng, Michele W.L., Moeller, Maria, Darcy, Phillip K., Kershaw, Michael H.

“…The immune system provides an attractive option for use in cancer therapy. Our increasing understanding of the molecular events important in the generation of…”
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Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth by Kershaw, M H, Darcy, P K, Trapani, J A, MacGregor, D, Smyth, M J

“…Antibodies have found application in the diagnosis and therapy of cancer. These antitumor antibodies are confined to isotypes of IgG and little is known of the…”
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