Search Results - "Darbre, P"

Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast by Darbre, P. D.

“…Many compounds in the environment have been shown capable of binding to cellular oestrogen receptors and then mimicking the actions of physiological…”
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Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum by Barr, L., Metaxas, G., Harbach, C. A. J., Savoy, L. A., Darbre, P. D.

“…ABSTRACT The concentrations of five esters of p‐hydroxybenzoic acid (parabens) were measured using HPLC‐MS/MS at four serial locations across the human breast…”
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Oestrogenic and androgenic activity of triclosan in breast cancer cells by Gee, R. H., Charles, A., Taylor, N., Darbre, P. D.

“…As a consequence of its widespread use as an antimicrobial agent in consumer goods, triclosan has become distributed ubiquitously across the ecosystem, and…”
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Aluminium, antiperspirants and breast cancer by Darbre, P.D.

“…Aluminium salts are used as the active antiperspirant agent in underarm cosmetics, but the effects of widespread, long term and increasing use remain unknown,…”
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Measurement of concentrations of four chemical ultraviolet filters in human breast tissue at serial locations across the breast by Barr, L., Alamer, M., Darbre, P. D.

“…The human population is widely exposed to benzophenone‐3 (BP‐3), octylmethoxycinnamate (OMC), 4‐methylbenzilidenecamphor (4‐MBC) and homosalate from their use…”
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Environmental oestrogens, cosmetics and breast cancer by Darbre, P.D.

“…The established role of oestrogen in the development and progression of breast cancer raises questions concerning a potential contribution from the many…”
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Concentrations of parabens in human breast tumours by Darbre, P. D., Aljarrah, A., Miller, W. R., Coldham, N. G., Sauer, M. J., Pope, G. S.

“…Parabens are used as preservatives in many thousands of cosmetic, food and pharmaceutical products to which the human population is exposed. Although recent…”
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Underarm cosmetics and breast cancer by Darbre, P. D.

“…Although risk factors are known to include the loss of function of the susceptibility genes BRCA1/BRCA2 and lifetime exposure to oestrogen, the main causative…”
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Aluminium and the human breast by Darbre, P.D.

“…The human population is exposed to aluminium (Al) from diet, antacids and vaccine adjuvants, but frequent application of Al-based salts to the underarm as…”
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Aluminium and human breast diseases by Darbre, P.D., Pugazhendhi, D., Mannello, F.

“…The human breast is exposed to aluminium from many sources including diet and personal care products, but dermal application of aluminium-based antiperspirant…”
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Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro by Charles, A. K., Darbre, P. D.

“…Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) are added to bodycare cosmetics used around the human breast. We report here that…”
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Effects of aluminium chloride and aluminium chlorohydrate on DNA repair in MCF10A immortalised non-transformed human breast epithelial cells by Farasani, A., Darbre, P.D.

“…Use of underarm aluminium (Al)-based antiperspirant salts may be a contributory factor in breast cancer development. At the 10th Keele meeting, Al was reported…”
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Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells by Matsumura, A., Ghosh, A., Pope, G.S., Darbre, P.D.

“…Previous studies have compared the oestrogenic properties of phytoestrogens in a wide variety of disparate assays. Since not all phytoestrogens have been…”
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Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines by Pugazhendhi, D., Pope, G. S., Darbre, P. D.

“…This paper addresses the question of whether p‐hydroxybenzoic acid, the common metabolite of parabens, possesses oestrogenic activity in human breast cancer…”
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Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells by Pugazhendhi, D, Watson, K A, Mills, S, Botting, N, Pope, G S, Darbre, P D

“…The phytoestrogens genistein, daidzein and the daidzein metabolite equol have been shown previously to possess oestrogen agonist activity. However, following…”
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Oestrogenic activity of parabens in MCF7 human breast cancer cells by Byford, J.R, Shaw, L.E, Drew, M.G.B, Pope, G.S, Sauer, M.J, Darbre, P.D

“…Parabens (4-hydroxybenzoic acid esters) have been recently reported to have oestrogenic activity in yeast cells and animal models. Since the human population…”
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Underarm cosmetics are a cause of breast cancer by Darbre, P D

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Oestrogenic activity of benzylparaben by Darbre, P. D., Byford, J. R., Shaw, L. E., Hall, S., Coldham, N. G., Pope, G. S., Sauer, M. J.

“…Previous work has demonstrated that the alkyl esters of p‐hydroxybenzoic acid (parabens) possess oestrogenic activity, which increases with length of alkyl…”
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Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17β-oestradiol in MCF7 human breast cancer cells by Pugazhendhi, D., Sadler, A. J., Darbre, P. D.

“…Since the alkyl esters of p‐hydroxybenzoic acid (parabens) can be measured intact in the human breast and possess oestrogenic properties, it has been suggested…”
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Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human breast cancer cells by Sadler, A.J., Pugazhendhi, D., Darbre, P.D.

“…Over the years, the MCF7 human breast cancer cell line has provided a model system for the study of cellular and molecular mechanisms in oestrogen regulation…”
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