Search Results - "Daraio, Filomena"

Monitoring Chronic Myeloid Leukemia: How Molecular Tools May Drive Therapeutic Approaches by Izzo, Barbara, Gottardi, Enrico Marco, Errichiello, Santa, Daraio, Filomena, Baratè, Claudia, Galimberti, Sara

“…More than 15 years ago, imatinib entered into the clinical practice as a "magic bullet"; from that point on, the prognosis of patients affected by chronic…”
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Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts by Dragani, Matteo, Petiti, Jessica, Rege-Cambrin, Giovanna, Gottardi, Enrico, Daraio, Filomena, Caocci, Giovanni, Aguzzi, Chiara, Crisà, Elena, Andreani, Giacomo, Caciolli, Francesca, Fava, Carmen

“…Discontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the…”
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Alignment of Qx100/Qx200 Droplet Digital (Bio-Rad) and QuantStudio 3D (Thermofisher) Digital PCR for Quantification of BCR-ABL1 in Ph+ Chronic Myeloid Leukemia by Fava, Carmen, Bernardi, Simona, Gottardi, Enrico Marco, Lorenzatti, Roberta, Galeotti, Laura, Ceccherini, Francesco, Cordoni, Francesco, Daraio, Filomena, Giugliano, Emilia, Jovanovski, Aleksandar, Petiti, Jessica, Varotto, Marta, Barberio, Davide, Rege-Cambrin, Giovanna, Berchialla, Paola, Sciannameo, Veronica, Malagola, Michele, Saglio, Giuseppe, Russo, Domenico

“…In recent years, the digital polymerase chain reaction has received increasing interest as it has emerged as a tool to provide more sensitive and accurate…”
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Genetic and clinical heterogeneity of ferroportin disease by Cemonesi, Laura, Forni, Gian Luca, Soriani, Nadia, Lamagna, Martina, Fermo, Isabella, Daraio, Filomena, Galli, Anna, Pietra, Daniela, Malcovati, Luca, Ferrari, Maurizio, Camaschella, Clara, Cazzola, Mario

“…Summary Ferroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin. SLC40A1 gene mutations are associated with…”
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A Comparison of Droplet Digital PCR and RT-qPCR for BCR-ABL1 Monitoring in Chronic Myeloid Leukemia by Fava, Carmen, Berchialla, Paola, Petiti, Jessica, Bochicchio, Maria Teresa, Izzo, Barbara, Giugliano, Emilia, Ottaviani, Emanuela, Errichiello, Santa, Rege Cambrin, Giovanna, Venturi, Claudia, Luciano, Luigiana, Daraio, Filomena, Calistri, Daniele, Martino, Alessandro, Saglio, Giuseppe, Martinelli, Giovanni, Pane, Fabrizio, Cilloni, Daniela, Gottardi, Enrico Marco

“…Background: Monitoring of BCR-ABL1 molecular levels is essential for the management of Chronic Myeloid Leukemia (CML) patients treated with Tyrosine Kinases…”
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A New Sensitive and Fast Molecular Analysis Method for the Identification of 30 Different Markers in Acute Myeloid and Lymphoid Leukemias at Diagnosis Time by Giugliano, Emilia, Lorenzatti, Roberta, Gottardi, Enrico Marco, Sammartino, Chiara, Toja, Roberta, Crasto, Francesca, Volpengo, Alessandro, Fantino, Cristina, Daraio, Filomena, Serra, Anna, Carnuccio, Francesca, Saglio, Giuseppe, Guerrasio, Angelo

“…Background: Medical advances in the treatment of Acute and Chronic Leukemia in the last decade were exciting, thanks to the discovery of new drugs and…”
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Droplet Digital PCR for BCR–ABL1 Monitoring in Diagnostic Routine: Ready to Start? by Bochicchio, Maria Teresa, Petiti, Jessica, Berchialla, Paola, Izzo, Barbara, Giugliano, Emilia, Ottaviani, Emanuela, Errichiello, Santa, Rege-Cambrin, Giovanna, Venturi, Claudia, Luciano, Luigiana, Daraio, Filomena, Calistri, Daniele, Rosti, Gianantonio, Saglio, Giuseppe, Martinelli, Giovanni, Pane, Fabrizio, Cilloni, Daniela, Gottardi, Enrico M., Fava, Carmen

“…BCR–ABL1 mRNA levels represent the key molecular marker for the evaluation of minimal residual disease (MRD) in chronic myeloid leukemia (CML) patients and…”
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Standardization of Two Dpcr Platforms for Detection of BCR/ABL1 - Minimal Residual Disease (MRD) in Ph+ Chronic Myeloid Leukemia (CML) by Fava, Carmen, Bernardi, Simona, Gottardi, Enrico Marco, Daraio, Filomena, Giugliano, Emilia, Lorenzatti, Roberta, Varotto, Marta, Barberio, Davide, Galeotti, Laura, Ceccherini, Francesco, Cordoni, Francesco, Rege-Carmbrin, Giovanna, Saglio, Giuseppe, Russo, Domenico

“…Background: despite the international efforts on standardization, qPCR has some intrinsic limitations of accuracy and sensitivity that make it suboptimal to…”
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An Italian Multicentre Study Using Different Digital PCR Instruments on BCR-ABL1 Positive Patients at Different Levels of CML Disease by Daraio, Filomena, Giugliano, Emilia, Fava, Carmen, Lorenzatti, Roberta, Varotto, Marta, Barberio, Davide, Bernardi, Simona, Izzo, Barbara, Errichiello, Santa, Bochicchio, Maria Teresa, Venturi, Claudia, Albano, Francesco, Saglio, Giuseppe, Pane, Fabrizio, Martinelli, Giovanni, Specchia, Giorgina, Russo, Domenico, Gottardi, Enrico Marco

“…Background: Monitoring of BCR-ABL1 levels by quantitative PCR (qPCR) is essential for the management of CML patients treated with TKIs. Because of intrinsic…”
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One-Step Quantitative Molecular Approach for Detection of BCR/ABL1 Rearrangement and for Monitoring of Minimal Residual Disease in CML Patients: An Inter Laboratory Study by Daraio, Filomena, Bochicchio, Maria Teresa, Izzo, Barbara, Venturi, Claudia, Errichiello, Santa, Crasto, Francesca, Rege-Cambrin, Giovanna, Lorenzatti, Roberta, Fava, Carmen, Castagnetti, Fausto, Pane, Fabrizio, Martinelli, Giovanni, Saglio, Giuseppe, Gottardi, Enrico Marco

“…▪ Molecular tests are the best way to monitor CML course in patients under treatment with tyrosine kinase inhibitors (TKI). International guidelines indicate…”
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Early BCR-ABL1 Reduction Is Predictive of Better Event-free Survival in Patients With Newly Diagnosed Chronic Myeloid Leukemia Treated With Any Tyrosine Kinase Inhibitor by Fava, Carmen, Rege-Cambrin, Giovanna, Dogliotti, Irene, Gottardi, Enrico, Berchialla, Paola, Di Gioacchino, Bruno, Crasto, Francesca, Lorenzatti, Roberta, Volpengo, Alessandro, Daraio, Filomena, Fantino, Cristina, Saglio, Giuseppe

“…The clinical prognostic factors during treatment are very important in chronic myeloid leukemia. An early molecular response and the halving time of BCR-ABL1…”
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Philadelphia-positive lymphoblastic lymphoma: a case report and review of the literature by Dragani, Matteo, Andreani, Giacomo, Fava, Carmen, Daraio, Filomena, Gottardi, Enrico, Giugliano, Emilia, Nicoli, Paolo, Rege-Cambrin, Giovanna

“…Philadelphia positive acute lymphoblastic leukemia is well documented nowadays but very little is known about Philadelphia positive lymphoblastic lymphoma…”
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Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis by Lanzara, Carmela, Roetto, Antonella, Daraio, Filomena, Rivard, Silvain, Ficarella, Romina, Simard, Hervey, Cox, Timothy M., Cazzola, Mario, Piperno, Alberto, Gimenez-Roqueplo, Anne-Paule, Grammatico, Paola, Volinia, Stefano, Gasparini, Paolo, Camaschella, Clara

“…Juvenile or type 2 hemochromatosis (JH) is transmitted as a recessive trait that leads to severe iron overload and organ damage typically before age 30 years…”
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Consistency Of RQ-PCR Analysis Results In Peripheral Blood and Bone Marrow Samples In Chronic Myeloid Leukemia Patients: Relevance From The Practical and Logistic Point Of View by Rege-Cambrin, Giovanna, Fava, Carmen, Gottardi, Enrico, Daraio, Filomena, Giugliano, Emilia, Crasto, Francesca, Lorenzatti, Roberta, Volpengo, Alessandro, Di Gioacchino, Bruno, Saglio, Giuseppe

“…Consensus has been achieved that standardized molecular quantitative analysis (RQ-PCR) on peripheral blood (PB) is a suitable method for monitoring residual…”
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Evaluation of Cepheid Xpert® BCR-ABL Monitor Assay in Three Italian Reference Centers for Monitoring of BCR-ABL Transcript Levels in CML Patients by Bochicchio, Maria Teresa, Izzo, Barbara, Gottardi, Enrico, De Angelis, Biagio, Lorenzatti, Roberta, Venturi, Claudia, Crasto, Francesca, De Benedittis, Caterina, Daraio, Filomena, Ottaviani, Emanuela, Volpengo, Alessandro, Saglio, Giuseppe, Pane, Fabrizio, Martinelli, Giovanni

“…▪ Effective management of tyrosine kinase inhibitor (TKI) therapy for patients with CML requires frequent patient testing to monitor patient disease status…”
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Standard and High Sensitivity Molecular Analysis in Chronic Myeloid Leukemia Patients Candidate to Discontinuation of Tyrosine Kinase Inhibitors by Irene, Dogliotti, Carmen, Fava, Enrico, Gottardi, Filomena, Daraio, Emilia, Giugliano, Stefan, Ulisciani, Saglio, Giuseppe, Giovanna, Rege-Cambrin

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One Step Quantitative Molecular Approach for Detection of BCR/ABL Translocation and for Monitoring and Follow up of the Minimal Residual Disease in CML Patients Under Tyrosine Kines Inhibitors Treatment by Daraio, Filomena, Barberis, Davide, Crasto, Francesca, Rege-Cambrin, Giovanna, Olivo, Cristina, Renzulli, Matteo, Volpi, Rosy, Lorenzatti, Roberta, Fava, Carmen, Gottardi, Enrico, Saglio, Giuseppe

“…Abstract 4435 In patients with chronic myeloid leukemia (CML) a correct and careful monitoring of the response to treatment with tyrosine kinase inhibitors…”
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A Sensitive Replicate RQ-PCR of BCR ABL Transcripts Suggests That A Large Portion of Long Term Post Allogeneic SCT CML Patients Are in Deep MR and May Therefore Be Cured From Their Disease by Koren-Michowitz, Maya, Shimoni, Avichai, Daraio, Filomena, Crasto, Francesca, Lorenzatti, Roberta, Volchek, Yulia, Amariglio, Ninette, Gottardi, Enrico, Saglio, Giuseppe, Nagler, Arnon

“…Abstract 1690 RQ-PCR has become the major method for the follow up of CML pts in the tyrosine kinase inhibitor (TKI) era. In CML pts undergoing allogeneic SCT…”
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Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene by Girelli, Domenico, Bozzini, Claudia, Roetto, Antonella, Alberti, Federica, Daraio, Filomena, Colombari, Romano, Olivieri, Oliviero, Corrocher, Roberto, Camaschella, Clara

“…Although most patients with hereditary hemochromatosis are homozygous for a single mutation of the HFE gene on chromosome 6p, accumulating evidence indicates…”
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Early BCR-ABL reduction is predictive of better Event Free Survival in Chronic Myeloid Leukemia newly diagnosed patients treated with any Tyrosine Kinase Inhibitors by Fava, Carmen, Rege-Cambrin, Giovanna, Dogliotti, Irene, Gottardi, Enrico, Berchialla, Paola, Di Gioacchino, Bruno, Crasto, Francesca, Lorenzatti, Roberta, Volpengo, Alessandro, Daraio, Filomena, Fantino, Cristina, Saglio, Giuseppe

“…Abstract Background Early molecular response has a strong predictive value in Chronic Myeloid Leukemia (CML). Recently the halving time has shown to represent…”
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