Search Results - "Daquan Gao"

Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543 by Ju, TongFa, Gao, DaQuan, Fang, Zheng-yu

“…In this study, we showed that PF-543, a novel sphingosine kinase 1 (SphK1) inhibitor, exerted potent anti-proliferative and cytotoxic effects against a panel…”
Get full text

Top management team career experience heterogeneity, digital transformation, and the corporate green innovation: a moderated mediation analysis by Gao, Daquan, Li, Songsong, Guo, Chang

“…Introduction Drawing upon upper echelon theory and the resource-based view, this study employs a moderated mediation model to investigate the moderating role…”
Get full text

Corporate Governance, Agency Costs, and Corporate Sustainable Development: A Mediating Effect Analysis by Li, Songsong, Gao, Daquan, Hui, Xiaofeng

“…The economy is an essential factor in constructing a resilient city, and listed companies play a vital role in the local economy. From the microbehavior of…”
Get full text

Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells by Ju, Tongfa, Jin, Huicheng, Ying, Rongchao, Xie, Qi, Zhou, Chunhua, Gao, Daquan

“…Colorectal carcinoma (CRC) is one of the most common types of malignancy worldwide. Recently, neoadjuvant chemotherapy has become an important treatment…”
Get full text

Computational Redesign of Human Butyrylcholinesterase for Anticocaine Medication by Yongmei Pan, Daquan Gao, Wenchao Yang, Hoon Cho, Guangfu Yang, Tai, Hsin-Hsiung, Chang-Guo Zhan

“…Molecular dynamics was used to simulate the transition state for the first chemical reaction step (TS1) of cocaine hydrolysis catalyzed by human…”
Get full text

Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity by Gao, Daquan, Narasimhan, Diwahar L, Macdonald, Joanne, Brim, Remy, Ko, Mei-Chuan, Landry, Donald W, Woods, James H, Sunahara, Roger K, Zhan, Chang-Guo

“…Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and…”
Get more information

Catalytic Mechanism and Energy Barriers for Butyrylcholinesterase-Catalyzed Hydrolysis of Cocaine by Zhan, Chang-Guo, Gao, Daquan

“…The geometries of the transition states, intermediates, and prereactive enzyme-substrate complex and the corresponding energy barriers have been determined by…”
Get full text

Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase by Gao, Daquan, Zhan, Chang-Guo

“…Molecular dynamics (MD) simulations and quantum mechanical/molecular mechanical (QM/MM) calculations were performed on the prereactive enzyme‐substrate…”
Get full text

Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2 by Cho, Hoon, Huang, Lingyu, Hamza, Adel, Gao, Daquan, Zhan, Chang-Guo, Tai, Hsin-Hsiung

“…Gln-148 of human 15-hydroxyprostaglandin dehydrogenase is important in the proper positioning of the C-15 hydroxyl group of the prostaglandin E2 during…”
Get full text

Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis by Huang, Xiaoqin, Yan, Weili, Gao, Daquan, Tong, Min, Tai, Hsin-Hsiung, Zhan, Chang-Guo

“…Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) has recently been recognized as a novel, promising drug target for inflammation-related diseases…”
Get full text

Investment efficiency, ESG performance and corporate performance: evidence from Chinese listed enterprises by Gao, Daquan, Li, Songsong, Zhou, Yan

“…Purpose This study aims to propose a moderated mediation model to investigate the moderating effects of environmental, social and governance (ESG) performance…”
Get full text

Relationship between Chirality Content and Stereoinduction:  Identification of a Chiraphore by Gao, Daquan, Schefzick, Sabine, Lipkowitz, Kenny B

Get full text

Modeling the Catalysis of Anti-Cocaine Catalytic Antibody: Competing Reaction Pathways and Free Energy Barriers by Pan, Yongmei, Gao, Daquan, Zhan, Chang-Guo

“…The competing reaction pathways and the corresponding free energy barriers for cocaine hydrolysis catalyzed by an anti-cocaine catalytic antibody, mAb15A10,…”
Get full text

Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States by Zheng, Fang, Yang, Wenchao, Ko, Mei-Chuan, Liu, Junjun, Cho, Hoon, Gao, Daquan, Tong, Min, Tai, Hsin-Hsiung, Woods, James H, Zhan, Chang-Guo

“…Cocaine is recognized as the most reinforcing of all drugs of abuse. There is no anticocaine medication available. The disastrous medical and social…”
Get full text

Free Energy Perturbation (FEP) Simulation on the Transition States of Cocaine Hydrolysis Catalyzed by Human Butyrylcholinesterase and Its Mutants by Pan, Yongmei, Gao, Daquan, Yang, Wenchao, Cho, Hoon, Zhan, Chang-Guo

“…A novel computational protocol based on free energy perturbation (FEP) simulations on both the free enzyme and transition state structures has been developed…”
Get full text

Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations by Huang, Xiaoqin, Gao, Daquan, Zhan, Chang-Guo

“…Cocaine esterase (CocE) has been known as the most efficient native enzyme for metabolizing naturally occurring cocaine. A major obstacle to the clinical…”
Get more information

Neutropenic enterocolitis in adults with hematological malignancy afte intensive cheMotherapy by Yaping, Xie, Huang, Xilian, Shi, Pengfei, Chen, Kuang, Gao, Daquan, Qian, Shenxian

“…Background. Neutropenic enterocolitis (NE) is a life-threatening complication occurring after intensive chemotherapy; however, only a few data are available…”
Get full text

Free Energy Perturbation Simulation on Transition States and High-Activity Mutants of Human Butyrylcholinesterase for (−)-Cocaine Hydrolysis by Yang, Wenchao, Pan, Yongmei, Fang, Lei, Gao, Daquan, Zheng, Fang, Zhan, Chang-Guo

“…A unified computational approach based on free energy perturbation (FEP) simulations of transition states has been employed to calculate the mutation-caused…”
Get full text

Clinical Study of Autologous Cytokine-Induced Killer Cells for the Consolidation Treatment of Elderly Patients with Diffuse Large B-Cell Lymphoma by Qian, Shenxian, Shi, Pengfei, Xie, Yaping, Xu, Ying, Gao, Daquan, Liu, Lirong, Huang, Xilian, Chen, Kuang, Tan, Junfeng

“…Cytokine-induced killer (CIK) cells are activated T cells with natural killer (NK) properties that can be expanded in vitro in presence of recombinant human…”
Get full text

Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia by Huang, Xilian, Xie, Yaping, Gao, Daquan, Shi, Pengfei, Qian, Shenxian

“…This case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×10⁹/l,…”
Get full text