Search Results - "Daphne Merkus"

Porcine models for studying complications and organ crosstalk in diabetes mellitus by Renner, Simone, Blutke, Andreas, Clauss, Sebastian, Deeg, Cornelia A., Kemter, Elisabeth, Merkus, Daphne, Wanke, Rüdiger, Wolf, Eckhard

“…The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in adults but also in children and adolescents. Diabetes is associated…”
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The microcirculation: a key player in obesity-associated cardiovascular disease by Sorop, Oana, Olver, T Dylan, van de Wouw, Jens, Heinonen, Ilkka, van Duin, Richard W, Duncker, Dirk J, Merkus, Daphne

“…It is increasingly recognized that obesity is a risk factor for microvascular disease, involving both structural and functional changes in the…”
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Regulation of Coronary Blood Flow in Health and Ischemic Heart Disease by Duncker, Dirk J, Koller, Akos, Merkus, Daphne, Canty, John M

“…Abstract The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been…”
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Experimental animal models of coronary microvascular dysfunction by Sorop, Oana, van de Wouw, Jens, Chandler, Selena, Ohanyan, Vahagn, Tune, Johnathan D, Chilian, William M, Merkus, Daphne, Bender, Shawn B, Duncker, Dirk J

“…Abstract Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important…”
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A tryst of 'blood pressure control- sex- comorbidities': the odyssey of basic public health services in Yunnan in quest for truth by Pang, Linhong, Kottu, Lakshme, Guo, Zihong, Ma, Min, Wang, Huadan, Zhao, Yajing, Tang, Mingjing, Shi, Yi, Liu, Wei, Wu, Xia, Song, Junjie, Sun, Manli, Merkus, Daphne, Ferdous, Md Misbahul, He, Liping, Duo, Lin

“…The Basic Public Health Service (BPHS), a recently announced free healthcare program, aims to combat the most prevalent Noncommunicable Disease-"Hypertension"…”
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Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets by van de Wouw, Jens, Broekhuizen, Michelle, Sorop, Oana, Joles, Jaap A., Verhaar, Marianne C., Duncker, Dirk J., Danser, A. H. Jan, Merkus, Daphne

“…Heart failure (HF) and chronic kidney disease (CKD) co-exist, and it is estimated that about 50% of HF patients suffer from CKD. Although studies have been…”
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Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation by Brandt, Maarten M, Cheng, Caroline, Merkus, Daphne, Duncker, Dirk J, Sorop, Oana

“…The coronary microvasculature plays a key role in regulating the tight coupling between myocardial perfusion and myocardial oxygen demand across a wide range…”
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Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network by Zhang, Hengliang, Merkus, Daphne, Zhang, Pei, Zhang, Huifeng, Wang, Yanyu, Du, Laijing, Kottu, Lakshme

“…Background: The mortality and disability rates of acute coronary syndrome (ACS) are quite high. Circular RNA (circRNA) is a competitive endogenous RNA (ceRNA)…”
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Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction by Nguyen, Isabel T N, Brandt, Maarten M, van de Wouw, Jens, van Drie, Ruben W A, Wesseling, Marian, Cramer, Maarten J, de Jager, Saskia C A, Merkus, Daphne, Duncker, Dirk J, Cheng, Caroline, Joles, Jaap A, Verhaar, Marianne C

“…Heart failure with a preserved ejection fraction (HFpEF) is associated with multiple comorbidities, such as old age, hypertension, type 2 diabetes and obesity…”
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Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes by Zhang, Hengliang, Sen, Payel, Hamers, Jules, Sittig, Theresa, Woestenburg, Brent, Moretti, Allessandra, Dendorfer, Andreas, Merkus, Daphne

“…Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other…”
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Right ventricular phenotype, function, and failure: a journey from evolution to clinics by Taverne, Yannick J. H. J., Sadeghi, Amir, Bartelds, Beatrijs, Bogers, Ad J. J. C., Merkus, Daphne

“…The right ventricle has long been perceived as the “low pressure bystander” of the left ventricle. Although the structure consists of, at first glance, the…”
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Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update by Zhou, Zhichao, Matsumoto, Takayuki, Jankowski, Vera, Pernow, John, Mustafa, S. Jamal, Duncker, Dirk J., Merkus, Daphne

“…[Display omitted] Uridine adenosine tetraphosphate (Up4A), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially…”
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Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone by Rapoport, Robert M, Merkus, Daphne

“…Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the…”
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Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals? by te Lintel Hekkert, Maaike, Newton, Gary, Chapman, Kathryn, Aqil, Rehan, Downham, Robert, Yan, Robert, Merkus, Daphne, Whitlock, Gavin, Lane, Charlotte A. L., Cawkill, Darren, Perrior, Trevor, Duncker, Dirk J., Schneider, Michael D.

“…Reducing infarct size (IS) by interfering with mechanisms for cardiomyocyte death remains an elusive goal. DMX-5804, a selective inhibitor of the…”
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Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease by van de Wouw, Jens, Sorop, Oana, van Drie, Ruben W. A., van Duin, Richard W. B., Nguyen, Isabel T. N., Joles, Jaap A., Verhaar, Marianne C., Merkus, Daphne, Duncker, Dirk J.

“…Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with…”
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Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation by Sun, Changyan, Jiao, Tong, Merkus, Daphne, Duncker, Dirk J., Mustafa, S. Jamal, Zhou, Zhichao

“…Activation of both adenosine A 2A and A 2B receptors (A 2B R) contributes to coronary vasodilation. We previously demonstrated that uridine adenosine…”
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Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities by van de Wouw, Jens, Steenhorst, Jarno J., Sorop, Oana, van Drie, Ruben W. A., Wielopolski, Piotr A., Kleinjan, Alex, Hirsch, Alexander, Duncker, Dirk J., Merkus, Daphne

“…Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes…”
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A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research by Schüttler, Dominik, Tomsits, Philipp, Bleyer, Christina, Vlcek, Julia, Pauly, Valerie, Hesse, Nora, Sinner, Moritz, Merkus, Daphne, Hamers, Jules, Kääb, Stefan, Clauss, Sebastian

“…Over the past years, the use of large animals has become increasingly interesting in translational research, to bridge the gap between basic research in…”
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Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension by Sen, Payel, Shashikadze, Bachuki, Flenkenthaler, Florian, Van de Kamp, Esther, Tian, Siyu, Meng, Chen, Gigl, Michael, Fröhlich, Thomas, Merkus, Daphne

“…Pulmonary vein stenosis (PVS) causes a rare type of pulmonary hypertension (PH) by impacting the flow and pressure within the pulmonary vasculature, resulting…”
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Purinergic Dysfunction in Pulmonary Arterial Hypertension by Cai, Zongye, Tu, Ly, Guignabert, Christophe, Merkus, Daphne, Zhou, Zhichao

“…Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance,…”
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