Search Results - "Dantzer, Françoise"

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage by Chen, Qian, Kassab, Muzaffer Ahmad, Dantzer, Françoise, Yu, Xiaochun

“…Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification involved in multiple biological processes, including DNA damage repair. This…”
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The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art by De Vos, Mike, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribose) polymerase (PARP) catalyzed poly(ADP-ribosyl)ation is one of the earliest post-translational modification of proteins detectable at sites of…”
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Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3 by Beck, Carole, Robert, Isabelle, Reina-San-Martin, Bernardo, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent…”
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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease by Cerutti, Raffaele, Pirinen, Eija, Lamperti, Costanza, Marchet, Silvia, Sauve, Anthony A., Li, Wei, Leoni, Valerio, Schon, Eric A., Dantzer, Françoise, Auwerx, Johan, Viscomi, Carlo, Zeviani, Massimo

“…Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of…”
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The expanding role of PARPs in the establishment and maintenance of heterochromatin by Dantzer, Françoise, Santoro, Raffaella

“…Poly(ADP‐ribose) polymerases (PARPs) are enzymes that transfer poly(ADP‐ribose) (PAR) groups to target proteins, and thereby affect various nuclear and…”
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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination by Robert, Isabelle, Dantzer, Françoise, Reina-San-Martin, Bernardo

“…Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA…”
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Enhancing cisplatin drug sensitivity through PARP3 inhibition: The influence on PDGF and G-coupled signal pathways in cancer by Varol, Ayşegül, Klauck, Sabine M., Dantzer, Françoise, Efferth, Thomas

“…Drug resistance poses a significant challenge in cancer treatment despite the clinical efficacy of cisplatin. Identifying and targeting biomarkers open new…”
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PARP3 comes to light as a prime target in cancer therapy by Rodriguez-Vargas, José Manuel, Nguekeu-Zebaze, Léonel, Dantzer, Françoise

“…Poly(ADP-ribose) polymerase 3 (PARP3) is the third member of the PARP family that catalyze a post-translational modification of proteins to promote, control or…”
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PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression by Dörsam, Bastian, Seiwert, Nina, Foersch, Sebastian, Stroh, Svenja, Nagel, Georg, Begaliew, Diana, Diehl, Erika, Kraus, Alexander, McKeague, Maureen, Minneker, Vera, Roukos, Vassilis, Reißig, Sonja, Waisman, Ari, Moehler, Markus, Stier, Anna, Mangerich, Aswin, Dantzer, Françoise, Kaina, Bernd, Fahrer, Jörg

“…Colorectal cancer (CRC) is one of the most common tumor entities, which is causally linked to DNA repair defects and inflammatory bowel disease (IBD). Here, we…”
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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression by Boehler, Christian, Gauthier, Laurent R, Mortusewicz, Oliver, Biard, Denis S, Saliou, Jean-Michel, Bresson, Anne, Sanglier-Cianferani, Sarah, Smith, Susan, Schreiber, Valérie, Boussin, François, Dantzer, Françoise

“…The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of…”
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New readers and interpretations of poly(ADP-ribosyl)ation by Kalisch, Thomas, Amé, Jean-Christophe, Dantzer, Françoise, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation (PARylation), a protein post-translational modification that was originally connected to the DNA damage response, is now known to engage…”
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Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss by Kelleher, Andrew M., Setlem, Rohit, Dantzer, Françoise, DeMayo, Francesco J., Lydon, John P., Kraus, W. Lee

“…Miscarriage is a common complication of pregnancy for which there are few clinical interventions. Deficiency in endometrial stromal cell decidualization is…”
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PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression by Boehler, Christian, Dantzer, Françoise

“…Comment on: Boehler C, et al. Proc Natl Acad Sci USA 2011; 108:2783-8…”
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Poly(ADP-ribose): novel functions for an old molecule by Schreiber, Valérie, Dantzer, Françoise, Ame, Jean-Christophe, de Murcia, Gilbert

“…The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique…”
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Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function by Galindo-Campos, Miguel A., Bedora-Faure, Marie, Farrés, Jordi, Lescale, Chloé, Moreno-Lama, Lucia, Martínez, Carlos, Martín-Caballero, Juan, Ampurdanés, Coral, Aparicio, Pedro, Dantzer, Françoise, Cerutti, Andrea, Deriano, Ludovic, Yélamos, José

“…Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic…”
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Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice by Moreno-Lama, Lucia, Galindo-Campos, Miguel A., Martínez, Carlos, Comerma, Laura, Vazquez, Ivonne, Vernet-Tomas, María, Ampurdanés, Coral, Lutfi, Nura, Martin-Caballero, Juan, Dantzer, Françoise, Quintela-Fandino, Miguel, Ali, Syed O., Jimeno, Jaime, Yélamos, José

“…Poly(ADP-ribose)-polymerase (PARP)-1 and PARP-2 play an essential role in the DNA damage response. Based on this effect of PARP in the tumor cell itself, PARP…”
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PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells by Nguekeu-Zebaze, Leonel, Hanini, Najat, Noll, Aurélia, Wadier, Nadège, Amé, Jean-Christophe, Roegel, Lisa, Dantzer, Françoise

“…In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a…”
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Toward specific functions of poly(ADP-ribose) polymerase-2 by Yélamos, José, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribose) polymerase-2 (PARP-2) belongs to a family of enzymes that catalyze poly(ADP-ribosyl)ation of proteins. PARP-1 and PARP-2 are so far the only…”
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Radiation-induced mitotic catastrophe in PARG-deficient cells by Amé, Jean-Christophe, Fouquerel, Elise, Gauthier, Laurent R, Biard, Denis, Boussin, François D, Dantzer, Françoise, de Murcia, Gilbert, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and…”
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Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation by Rodriguez-Vargas, José-Manuel, Martin-Hernandez, Kathline, Wang, Wei, Kunath, Nicolas, Suganthan, Rajikala, Amé, Jean-Christophe, Oliver, F. Javier, Ye, Jing, Bjørås, Magnar, Dantzer, Françoise

“…Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal…”
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