Search Results - "Danto, Spencer I."

Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects by Danto, Spencer I, Shojaee, Negin, Singh, Ravi Shankar P, Li, Cheryl, Gilbert, Steven A, Manukyan, Zorayr, Kilty, Iain

“…PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies…”
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Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis by Danto, Spencer I, Tsamandouras, Nikolaos, Reddy, Padma, Gilbert, Steven A, Mancuso, Jessica Y, Page, Karen, Beebe, Jean S, Peeva, Elena, Vincent, Michael S

“…PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the…”
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The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial by Winkler, Aaron, Sun, Weiyong, De, Saurav, Jiao, Aiping, Sharif, M. Nusrat, Symanowicz, Peter T., Athale, Shruti, Shin, Julia H., Wang, Ju, Jacobson, Bruce A., Ramsey, Simeon J., Dower, Ken, Andreyeva, Tatyana, Liu, Heng, Hegen, Martin, Homer, Bruce L., Brodfuehrer, Joanne, Tilley, Mera, Gilbert, Steven A., Danto, Spencer I., Beebe, Jean J., Barnes, Betsy J., Pascual, Virginia, Lin, Lih‐Ling, Kilty, Iain, Fleming, Margaret, Rao, Vikram R.

“…Objective To investigate the role of PF‐06650833, a highly potent and selective small‐molecule inhibitor of interleukin‐1–associated kinase 4 (IRAK4), in…”
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study by Danto, Spencer I., Tsamandouras, Nikolaos, Reddy, Padmalatha, Gilbert, Steven, Mancuso, Jessica, Page, Karen, Peeva, Elena, Vincent, Michael S., Beebe, Jean S.

“…PF‐06817024 is a high affinity, humanized antibody that binds interleukin‐33, a proinflammatory type 2 cytokine, and thereby has the potential to inhibit…”
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A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14 C-Microtracer Approach by Singh, Ravi Shankar P, Dowty, Martin E, Salganik, Mikhail, Brodfuehrer, Joanne I, Walker, Gregory S, Sharma, Raman, Beebe, Jean S, Danto, Spencer I

“…Zimlovisertib (PF-06650833) is a selective, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with anti-inflammatory effects. This…”
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A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach by Singh, Ravi Shankar P., Dowty, Martin E., Salganik, Mikhail, Brodfuehrer, Joanne I., Walker, Gregory S., Sharma, Raman, Beebe, Jean S., Danto, Spencer I.

“…Zimlovisertib (PF‐06650833) is a selective, reversible inhibitor of interleukin‐1 receptor‐associated kinase 4 (IRAK4) with anti‐inflammatory effects. This…”
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Na(+)-K(+)-ATPase expression in alveolar epithelial cells: upregulation of active ion transport by KGF by Borok, Z, Danto, S I, Dimen, L L, Zhang, X L, Lubman, R L

“…We evaluated the effects of keratinocyte growth factor (KGF) on alveolar epithelial cell (AEC) active ion transport and on rat epithelial Na channel (rENaC)…”
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Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells by Danto, S I, Borok, Z, Zhang, X L, Lopez, M Z, Patel, P, Crandall, E D, Lubman, R L

“…We investigated the effects of epidermal growth factor (EGF) on active Na+ absorption by alveolar epithelium. Rat alveolar epithelial cells (AEC) were isolated…”
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Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5 by Borok, Zea, Lubman, Richard L, Danto, Spencer I, Zhang, Xiao-Ling, Zabski, Stephanie M, King, Landon S, Lee, Douglas M, Agre, Peter, Crandall, Edward D

“…We investigated the role of keratinocyte growth factor (KGF) in regulation of alveolar epithelial cell (AEC) phenotype in vitro. Effects of KGF on cell…”
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Qualified kidney injury biomarkers demonstrate value during early clinical drug development by Ravindra, Kodihalli C, Fader, Kelly A, Potter, David, Radi, Zaher A, Friedman, Gary S, Brenneman, Karrie A, Amin, Neeta B, Weiss, Roberta, Danto, Spencer I, Page, Karen, Ramaiah, Shashi K, Vaidya, Vishal S

“…Drug-induced kidney injury (DIKI) is of significant concern, both during drug development and in clinical practice. We report a patient-centric approach for…”
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Modulation of pulmonary NA+ pump gene expression during cold storage and reperfusion by KIM, Jong D, BAKER, Craig J, DANTO, Spencer I, STARNES, Vaughn A, BARR, Mark L

“…Reperfusion injury with pulmonary edema continues to be a major complication after lung transplantation. Alveolar fluid homeostasis is regulated by…”
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MODULATION OF PULMONARY NA+ PUMP GENE EXPRESSION DURING COLD STORAGE AND REPERFUSION1 by Kim, Jong D., Baker, Craig J., Danto, Spencer I., Starnes, Vaughn A., Barr, Mark L.

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Effects of EGF on alveolar epithelial junctional permeability and active sodium transport by Borok, Z, Hami, A, Danto, S I, Lubman, R L, Kim, K J, Crandall, E D

“…We evaluated the effects of epidermal growth factor (EGF) on transepithelial resistance (Rt) and active ion transport by alveolar epithelial cell (AEC)…”
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Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies by Danto, S I, Zabski, S M, Crandall, E D

“…An understanding of the process of alveolar epithelial cell growth and differentiation requires the ability to trace and analyze the phenotypic transitions…”
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Rat serum inhibits progression of alveolar epithelial cells toward the type I cell phenotype in vitro by Borok, Z, Hami, A, Danto, S I, Zabski, S M, Crandall, E D

“…Serum contains a number of polypeptide growth factors, hormones, and soluble matrix components and may influence the state of differentiation of epithelial…”
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Cl(-)-HCO3- exchanger isoform AE2 is restricted to the basolateral surface of alveolar epithelial cell monolayers by Lubman, R L, Danto, S I, Chao, D C, Fricks, C E, Crandall, E D

“…We investigated the polarized distribution and isoform specificity of anion exchange (Cl(-)-HCO3- exchange) in alveolar epithelial cell monolayers. Rat…”
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Defined Medium for Primary Culture De Novo of Adult Rat Alveolar Epithelial Cells by Zea Borok, Danto, Spencer I., Stephanie M. Zabski, Edward D. Crandall

“…Isolated type II pneumocytes grown in serum on tissue culture-treated polycarbonate filters form monolayers with characteristic bioelectric properties, and…”
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Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro by Borok, Z, Danto, S I, Lubman, R L, Cao, Y, Williams, M C, Crandall, E D

“…T1alpha is a recently identified gene expressed in the adult rat lung by alveolar type I (AT1) epithelial cells but not by alveolar type II (AT2) epithelial…”
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Identification of Na(+)-K(+)-ATPase beta-subunit in alveolar epithelial cells by Zhang, X L, Danto, S I, Borok, Z, Eber, J T, Martín-Vasallo, P, Lubman, R L

“…The Na(+)-K(+)-ATPase is a heterodimeric plasma membrane protein that consists of a catalytic alpha-subunit and a smaller glycosylated beta-subunit that has…”
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Immunocytochemical Analysis of Intermediate Filaments in Embryonic Heart Cells with Monoclonal Antibodies to Desmin by Danto, Spencer I., Fischman, Donald A.

“…Monoclonal antibodies (McAbs) have been generated against a preparation of intermediate filament proteins (IFP) from adult chicken gizzard. Two antibodies, D3…”
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