Search Results - "Dantec, Aurélia Le"
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Yeast RNA exosome activity is necessary for maintaining cell wall stability through proper protein glycosylation
Published in Molecular biology of the cell (01-03-2021)“…Nuclear RNA exosome is the main 3'→5' RNA degradation and processing complex in eukaryotic cells and its dysregulation therefore impacts gene expression and…”
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Perturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome
Published in RNA biology (03-07-2019)“…Eukaryotic cells have evolved a nuclear quality control (QC) system to monitor the co-transcriptional mRNA processing and packaging reactions that lead to the…”
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Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho
Published in Journal of antibiotics (01-03-2018)“…The alarming issue of antibiotic resistance expansion requires a continuous search for new and efficient antibacterial agents. Here we describe the design of…”
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Deciphering the Dynamic Landscape of Transcription-Associated mRNP Quality Control Components Over the Whole Yeast Genome
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…In eukaryotic cells, aberrant mRNPs with processing and packaging defects are targeted co-transcriptionally by a surveillance system that triggers their…”
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Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis
Published in RNA (Cambridge) (01-01-2024)“…The eukaryotic THO complex coordinates the assembly of so-called messenger RNA-ribonucleoprotein particles (mRNPs), a process that involves cotranscriptional…”
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MP15-13 CHARACTERIZATION OF THE IMMUNE INFILTRATION IN HIGH GRADE NMIBC: IMMUNVESSIE PROJECT
Published in The Journal of urology (01-05-2024)Get full text
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New biomarkers for early diagnosis of Lesch-Nyhan disease revealed by metabolic analysis on a large cohort of patients
Published in Orphanet journal of rare diseases (23-01-2015)“…Lesch-Nyhan disease is a rare X-linked neurodevelopemental metabolic disorder caused by a wide variety of mutations in the HPRT1 gene leading to a deficiency…”
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