Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution

Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution

The intestinal microbiota plays an important role in the immune response against viral infections, modulating both innate and adaptive immune responses. The cytokine storm is associated with COVID-19 severity, and the patient’s immune status is influenced by the intestinal microbiota in a gut-lung b...

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Bibliographic Details
Published in:International journal of environmental research and public health Vol. 19; no. 16; p. 10189
Main Authors: Ferreira-Junior, Alexandre Soares, Borgonovi, Tais Fernanda, De Salis, Larissa Vedovato Vilela, Leite, Aline Zazeri, Dantas, Amanda Soares, De Salis, Guilherme Vedovato Vilela, Cruz, Giuliano Netto Flores, De Oliveira, Luiz Felipe Valter, Gomes, Eleni, Penna, Ana Lúcia Barretto, De Oliveira, Gislane Lelis Vilela
Format: Journal Article
Language:English
Published: Basel MDPI AG 17-08-2022
MDPI
Subjects:
Alopecia
Antibiotics
Asymptomatic
Body mass index
C-reactive protein
Cardiovascular disease
Chronic fatigue syndrome
Complications
Coronaviruses
COVID-19
Cytokine storm
Cytokines
Deoxyribonucleic acid
Diarrhea
DNA
Dysbacteriosis
Dyspnea
Gastrointestinal surgery
Genetic testing
Hematology
Immune response
Immune status
Immune system
Infections
Intestinal microflora
Intestine
Laboratories
Microbiota
Myalgia
Nucleotide sequence
Obesity
Pandemics
Patients
Respiration
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Tumor necrosis factor-TNF
Viral infections
Brazil
United States > US
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Summary:The intestinal microbiota plays an important role in the immune response against viral infections, modulating both innate and adaptive immune responses. The cytokine storm is associated with COVID-19 severity, and the patient’s immune status is influenced by the intestinal microbiota in a gut-lung bidirectional interaction. In this study, we evaluate the intestinal microbiota of Brazilian patients in different post-COVID-19 periods, and correlate this with clinical data and the antibiotic therapy used during the acute phase. DNA extracted from stool samples was sequenced and total anti-SARS-CoV-2 antibodies and C-reactive protein were quantified. Compared with controls, there were significant differences in the microbiota diversity in post-COVID-19 patients, suggesting an intestinal dysbiosis even several months after acute disease resolution. Additionally, we detected some genera possibly associated with the post-COVID-19 dysbiosis, including Desulfovibrio, Haemophillus, Dialister, and Prevotella, in addition to decreased beneficial microbes, associated with antibiotic-induced dysbiosis, such as Bifidobacterium and Akkermansia. Therefore, our hypothesis is that dysbiosis and the indiscriminate use of antibiotics during the pandemic may be associated with post-COVID-19 clinical manifestations. In our study, 39% (n = 58) of patients reported symptoms, including fatigue, dyspnea, myalgia, alopecia, anxiety, memory loss, and depression. These data suggest that microbiota modulation may represent a target for recovery from acute COVID-19 and a therapeutic approach for post-COVID-19 sequelae.
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ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph191610189