Search Results - "Danson, Michael"

Temperature and the catalytic activity of enzymes: A fresh understanding by Daniel, Roy M., Danson, Michael J.

“…The discovery of an additional step in the progression of an enzyme from the active to inactive state under the influence of temperature has led to a better…”
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The dependence of enzyme activity on temperature: determination and validation of parameters by Peterson, Michelle E, Daniel, Roy M, Danson, Michael J, Eisenthal, Robert

“…Traditionally, the dependence of enzyme activity on temperature has been described by a model consisting of two processes: the catalytic reaction defined by…”
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Catalytic efficiency and kcat / KM : a useful comparator? by Eisenthal, Robert, Danson, Michael J, Hough, David W

“…The ratio kcat / KM – often referred to as the ‘specificity constant’ – is a useful index for comparing the relative rates of an enzyme acting on alternative,…”
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The molecular basis of the effect of temperature on enzyme activity by Daniel, Roy M, Peterson, Michelle E, Danson, Michael J, Price, Nicholas C, Kelly, Sharon M, Monk, Colin R, Weinberg, Cristina S, Oudshoorn, Matthew L, Lee, Charles K

“…Experimental data show that the effect of temperature on enzymes cannot be adequately explained in terms of a two-state model based on increases in activity…”
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Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function by Wells, Stephen A., Crennell, Susan J., Danson, Michael J.

“…ABSTRACT Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly‐conserved structurally across the tree of life. Crystal…”
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Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius by Extance, Jonathan, Danson, Michael J., Crennell, Susan J.

“…Acetylating aldehyde dehydrogenases (AcAldDH) catalyse the acetylation of Coenzyme‐A (CoA), or in reverse generate acetaldehyde from Acetyl‐CoA using NADH as a…”
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Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors by Hindson, Sarah A., Andrews, Rachael C., Danson, Michael J., Kamp, Marc W., Manley, Amy E., Sutcliffe, Oliver B., Haines, Tom S. F., Freeman, Tom P., Scott, Jennifer, Husbands, Stephen M., Blagbrough, Ian S., Anderson, J. L. Ross, Carbery, David R., Pudney, Christopher R.

“…Synthetic cannabinoid receptor agonists (SCRAs) are one of the fastest growing classes of recreational drugs. Despite their growth in use, their vast chemical…”
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Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3‑Deoxy-hexulosonic Acid by Royer, Sylvain F., Gao, Xuan, Groleau, Robin R., van der Kamp, Marc W., Bull, Steven D., Danson, Michael J., Crennell, Susan J.

“…A 2-keto-3-deoxygluconate aldolase from the hyperthermophile Sulfolobus solfataricus catalyzes the nonstereoselective aldol reaction of pyruvate and…”
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Inhibition of extracellular proteases improves the production of a xylanase in Parageobacillus thermoglucosidasius by Holland, Alexandria T N, Danson, Michael J, Bolhuis, Albert

“…Parageobacillus thermoglucosidasius is a thermophilic and ethanol-producing bacterium capable of utilising both hexose and pentose sugars for fermentation. The…”
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Metabolism of Pentose Sugars in the Hyperthermophilic Archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius by Nunn, Charlotte E.M., Johnsen, Ulrike, Schönheit, Peter, Fuhrer, Tobias, Sauer, Uwe, Hough, David W., Danson, Michael J.

“…We have previously shown that the hyperthermophilic archaeon, Sulfolobus solfataricus, catabolizes d-glucose and d-galactose to pyruvate and glyceraldehyde via…”
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Insights into the Substrate Specificity of Archaeal Entner–Doudoroff Aldolases: The Structures of Picrophilus torridus 2‑Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2‑Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2‑Keto-3-deoxy-6-phosphogluconate by Zaitsev, Viatcheslav, Johnsen, Ulrike, Reher, Matthias, Ortjohann, Marius, Taylor, Garry L, Danson, Michael J, Schönheit, Peter, Crennell, Susan J

“…The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner–Doudoroff pathway and a…”
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Development of an efficient technique for gene deletion and allelic exchange in Geobacillus spp by Bacon, Leann F, Hamley-Bennett, Charlotte, Danson, Michael J, Leak, David J

“…Geobacillus thermoglucosidasius is a thermophilic, natural ethanol producer and a potential candidate for commercial bioethanol production. Previously, G…”
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Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea by Borziak, Kirill, Posner, Mareike G, Upadhyay, Abhishek, Danson, Michael J, Bagby, Stefan, Dorus, Steve

“…Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the…”
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Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover by Winter, Samuel D, Jones, Hannah B. L, Răsădean, Dora M, Crean, Rory M, Danson, Michael J, Pantoş, G. Dan, Katona, Gergely, Prentice, Erica, Arcus, Vickery L, van der Kamp, Marc W, Pudney, Christopher R

“…Uncovering the role of global protein dynamics in enzyme turnover is needed to fully understand enzyme catalysis. Recently, we have demonstrated that the heat…”
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A new understanding of how temperature affects the catalytic activity of enzymes by Daniel, Roy M., Danson, Michael J.

“…The two established thermal properties of enzymes are their activation energy and their thermal stability, but experimental data do not match the expectations…”
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Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius by Extance, Jonathan, Crennell, Susan J., Eley, Kirstin, Cripps, Roger, Hough, David W., Danson, Michael J.

“…Bifunctional alcohol/aldehyde dehydrogenase (ADHE) enzymes are found within many fermentative microorganisms. They catalyse the conversion of an acyl‐coenzyme…”
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Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex by Marrott, Nia L, Marshall, Jacqueline J T, Svergun, Dmitri I, Crennell, Susan J, Hough, David W, van den Elsen, Jean M H, Danson, Michael J

“…The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active…”
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A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds by Espina, Giannina, Eley, Kirstin, Pompidor, Guillaume, Schneider, Thomas R., Crennell, Susan J., Danson, Michael J.

“…Geobacillus thermoglucosidasius is a thermophilic bacterium that is able to ferment both C6 and C5 sugars to produce ethanol. During growth on hemicellulose…”
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Uncovering the Relationship between the Change in Heat Capacity for Enzyme Catalysis and Vibrational Frequency through Isotope Effect Studies by Jones, Hannah B. L, Crean, Rory M, Matthews, Christopher, Troya, Anna B, Danson, Michael J, Bull, Steven D, Arcus, Vickery L, van der Kamp, Marc W, Pudney, Christopher R

“…Understanding how enzyme catalysis varies with temperature is key to understanding catalysis itself and, ultimately, how to tune temperature optima…”
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Syntheses of 2-Keto-3-deoxy-D-xylonate and 2-Keto-3-deoxy-L-arabinonate as Stereochemical Probes for Demonstrating the Metabolic Promiscuity of Sulfolobus solfataricus Towards D-Xylose and L-Arabinose by Archer, Robert M., Royer, Sylvain F., Mahy, William, Winn, Caroline L., Danson, Michael J., Bull, Steven D.

“…Practical syntheses of 2‐keto‐3‐deoxy‐D‐xylonate (D‐KDX) and 2‐keto‐3‐deoxy‐L‐arabinonate (L‐KDA) that rely on reaction of the anion of ethyl…”
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