Search Results - "Danska, J."

The intestinal microbiome in type 1 diabetes by Dunne, J. L., Triplett, E. W., Gevers, D., Xavier, R., Insel, R., Danska, J., Atkinson, M. A.

“…Summary Few concepts in recent years have garnered more disease research attention than that of the intestinal (i.e. ‘gut’) microbiome. This emerging interest…”
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Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells by Hadjiyanni, I., Siminovitch, K. A., Danska, J. S., Drucker, D. J.

“…Aims/hypothesis Glucagon-like peptide-1 receptor (GLP-1R) agonists improve glucose control in animals and humans with type 1 diabetes. However, there is little…”
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Maternal autoimmune thyroid disease and the fetal immune system by Svensson, J, Oderup, C, Akesson, C, Uvebrant, K, Hallengren, B, Ericsson, U B, Arvastsson, J, Danska, J S, Lantz, M, Cilio, C M

“…Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in…”
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V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors by Guidos, C J, Williams, C J, Grandal, I, Knowles, G, Huang, M T, Danska, J S

“…Double-stranded DNA breaks (DSBs) trigger p53-mediated cell cycle arrest or apoptosis pathways that limit the oncogenic consequences of exposure to genotoxic…”
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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice by RAPOPORT, M. J, JARAMILLO, A, ZIPRIS, D, LAZARUS, A. H, SERREZE, D. V, LEITER, E. H, CYOPICK, P, DANSKA, J. S, DELOVITCH, T. L

“…Beginning at the time of insulitis (7 wk of age), CD4+ and CD8+ mature thymocytes from nonobese diabetic (NOD) mice exhibit a proliferative unresponsiveness in…”
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Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes by Danska, Jayne S., Holland, Dianne P., Mariathasan, Sanjeev, Williams, Kelly M., Guidos, Cynthia J.

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Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation by FOX, C. J, DANSKA, J. S

“…Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. C J Fox and J S Danska Hospital for Sick…”
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Rescue of T Cell-Specific V(D)J Recombination in SCID Mice by DNA-Damaging Agents by Danska, Jayne S., Pflumio, Francoise, Williams, Christine J., Huner, Ozgur, Dick, John E., Guidos, Cynthia J.

“…Assembly of antigen receptor V (variable), D (diversity), and J (joining) gene segments requires lymphocyte-specific genes and ubiquitous DNA repair…”
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Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis by Fox, Casey J., Paterson, Andrew D., Mortin-Toth, Steven M., Danska, Jayne S.

“…Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by progressive autoimmune infiltration (insulitis) of the pancreatic islets of…”
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The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk : A severe combined immune deficiency (SCID) murine model by LISTA, F, BERTNESS, V, GUIDES, C. J, DANSKA, J. S, KIRSCH, I. R

“…Pilot studies in human populations have demonstrated a correlation between the level of antigen receptor trans-rearrangements and risk (at the population…”
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IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice by Fox, CJ, Danska, JS

“…In nonobese diabetic mice, autoimmune diabetes progresses in an age-linked and gender-dependent manner. Insulitis begins in male and female mice at…”
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Genetic Control of T and B Lymphocyte Activation in Nonobese Diabetic Mice by Chiu, Priscilla P. L, Jevnikar, Anthony M, Danska, Jayne S

“…Type 1 diabetes in nonobese diabetic (NOD) mice is characterized by the infiltration of T and B cells into pancreatic islets. T cells bearing the TCR Vbeta3…”
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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice by Gladdy, Rebecca A., Taylor, Michael D., Williams, Christine J., Grandal, Ildiko, Karaskova, Jana, Squire, Jeremy A., Rutka, James T., Guidos, Cynthia J., Danska, Jayne S.

“…Double-strand DNA breaks (DSB) induce chromosomal translocations and gene amplification in cell culture, but mechanisms by which DSB cause genomic instability…”
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Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors by Williams, Christine J., Grandal, Ildiko, Vesprini, Danny J., Wojtyra, Urszula, Danska, Jayne S., Guidos, Cynthia J.

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Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice by CHIU, Priscilla P. L, SERREZE, David V, DANSKA, Jayne S

“…Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice Priscilla P.L. Chiu 1 2 4 , David V. Serreze 5 and Jayne S. Danska…”
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Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway by Guidos, C J, Williams, C J, Wu, G E, Paige, C J, Danska, J S

“…Antigen-binding diversity is generated by site-specific V(D)J recombination of the T cell receptor (TCR) and immunoglobulin loci in lymphocyte precursors…”
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Induction of a heterogeneous TCR repertoire in (PL/JXSJL/J)F1 mice by myelin basic protein peptide Ac1-11 and its analog Ac1-11[4A] by Pearson, C.I., Smilek, D.E., Danska, J.S., McDevitt, H.O.

“…Experimental autoimmune encephalomyelitis (EAE) serves as a rodent model of the autoimmune disease multiple sclerosis. In mice, EAE is induced by immunizing…”
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Peri-islet infiltrates of young non-obese diabetic mice display restricted TCR beta-chain diversity by Galley, KA, Danska, JS

“…To define the clonal diversity of autoreactive T cells associated with the induction of type 1 diabetes, we characterized TCR expression in the earliest…”
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Restriction fragment-length polymorphism analysis of the major histocompatibility complex in New Zealand white rabbits by Boyer, M I, Bowen, C V, Danska, J S

“…As a model system, rabbits are particularly useful in transplantation studies because of their size and accessibility. However, inbred rabbits of known MHC…”
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The T cell receptor: structure, molecular diversity and somatic localization by Danska, J S

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