Search Results - "Dannhardt, Gerd"

Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis: Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency by Rauwald, Hans Wilhelm, Maucher, Ralf, Dannhardt, Gerd, Kuchta, Kenny

“…The present study aims at the isolation and identification of diverse phenolic polyketides from Aloe vera (L.) Burm.f. and Aloe plicatilis (L.) Miller and…”
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Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo by Lirdprapamongkol, Kriengsak, Kramb, Jan-Peter, Suthiphongchai, Tuangporn, Surarit, Rudee, Srisomsap, Chantragan, Dannhardt, Gerd, Svasti, Jisnuson

“…Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In…”
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Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives by Hansen, Finn K., Khankischpur, Mehdi, Tolaymat, Ibrahim, Mesaros, Renata, Dannhardt, Gerd, Geffken, Detlef

“…A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX…”
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Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions by Jansen, Michaela, Dannhardt, Gerd

“…For decades neuroreceptor research has focused on the development of NMDA glycine-site antagonists, after Johnson and Ascher found out in 1987 about the…”
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The pyrrole moiety as a template for COX-1/COX-2 inhibitors by Dannhardt, Gerd, Kiefer, Werner, Krämer, Godehard, Maehrlein, Sabine, Nowe, Ulrike, Fiebich, Bernd

“…Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a…”
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A Novel Class of Potent Nonglycosidic and Nonpeptidic Pan-Selectin Inhibitors by Ulbrich, Holger K, Luxenburger, Andreas, Prech, Philip, Eriksson, Einar E, Soehnlein, Oliver, Rotzius, Pierre, Lindbom, Lennart, Dannhardt, Gerd

“…An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The…”
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Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis by Danz, Henning, Stoyanova, Stefka, Thomet, Olivier A R, Simon, Hans-Uwe, Dannhardt, Gerd, Ulbrich, Holger, Hamburger, Matthias

“…The indolo[2,1- b]quinazoline alkaloid tryptanthrin has previously been identified as the cyclooxygenase-2 (COX-2) inhibitory principle in the extract ZE550…”
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A Novel Quantitative Chick Embryo Assay as an Angiogenesis Model Using Digital Image Analysis by PEIFER, Christian, DANNHARDT, Gerd

“…A number of pathological events in humans such as solid tumour growth and metastasis have been found to be associated with angiogenesis, the formation of new…”
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Juice of Eclipta prostrata Inhibits Cell Migration In Vitro and Exhibits Anti-angiogenic Activity In Vivo by Lirdprapamongkol, Kriengsak, Kramb, Jan-Peter, Chokchaichamnankit, Daranee, Srisomsap, Chantragan, Surarit, Rudee, Sila-Asna, Monnipha, Bunyaratvej, Ahnond, Dannhardt, Gerd, Svasti, Jisnuson

“…Background: The invasion of cancer cells is critical for metastasis. The effects of Eclipta prostrata, a Thai medicinal plant, on invasion, migration and…”
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Characterization of a Computerized Assay for Rapid and Easy Determination of Leukocyte Adhesion to Endothelial Cells by Ulbrich, Holger, Prech, Philip, Luxenburger, Andreas, Dannhardt, Gerd

“…We report on a facile and rapid computerized in-vitro assay for the quantification of leukocyte adhesion to endothelial cells under static conditions using…”
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(6,7-Diaryldihydropyrrolizin-5-yl)acetic Acids, a Novel Class of Potent Dual Inhibitors of Both Cyclooxygenase and 5-Lipoxygenase by Laufer, Stefan A, Augustin, Jan, Dannhardt, Gerd, Kiefer, Werner

“…A novel class of nonantioxidant dual inhibitors of both CO and 5-LO is described. The balance between the activity against CO and 5-LO can be shifted by…”
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Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners by Banwell, Martin G, Bezos, Anna, Chand, Satish, Dannhardt, Gerd, Kiefer, Werner, Nowe, Ulrike, Parish, Christopher R, Savage, G Paul, Ulbrich, Holger

“…Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone-benzene afforded a ca. 2:1:2:1 mixture of the…”
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Cyclooxygenase inhibitors – current status and future prospects by Dannhardt, Gerd, Kiefer, Werner

“…Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and subsequent downstream synthetases. Two closely related forms of the…”
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Synthesis and evaluation of 5,7-dichloro-4-(3-{4-[4-(2-[18F]fluoroethyl)-piperazin-1-yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid as a potential NMDA ligand to study glutamatergic neurotransmission in vivo by Piel, Markus, Schirrmacher, Ralf, Höhnemann, Sabine, Hamkens, Wilhelm, Kohl, Beate, Jansen, Michaela, Schmitt, Ullrich, Lüddens, Hartmut, Dannhardt, Gerd, Rösch, Frank

“…The neurotransmitter glutamate is thought to be crucially involved in a huge number of neurological and psychiatric disorders, such as Morbus Parkinson,…”
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In-vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC by Dannhardt, G, Lehr, M

“…Inhibition of 5-lipoxygenase has been determined by monitoring the formation of leukotriene B4 and 5-hydroxyeicosatetraenoic acid in bovine polymorphonuclear…”
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Novel 3‑Azaindolyl-4-arylmaleimides Exhibiting Potent Antiangiogenic Efficacy, Protein Kinase Inhibition, and Antiproliferative Activity by Ganser, Christopher, Lauermann, Eva, Maderer, Annett, Stauder, Torsten, Kramb, Jan-Peter, Plutizki, Stanislav, Kindler, Thomas, Moehler, Markus, Dannhardt, Gerd

“…Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged…”
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Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles by Scholz, Michael, Ulbrich, Holger K., Dannhardt, Gerd

“…The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into…”
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SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s disease by Flesch, Daniel, Ness, Julia, Lamers, Christina, Dehm, Friederike, Popella, Sven, Steri, Ramona, Ogorek, Isabella, Hieke, Martina, Dannhardt, Gerd, Werz, Oliver, Weggen, Sascha, Schubert-Zsilavecz, Manfred

“…[Display omitted] We present the design, synthesis and biological evaluation of compounds containing a 2-(benzylidene)hexanoic acid scaffold as multi-target…”
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Synthesis of GABA A Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site by Jansen, Michaela, Rabe, Holger, Strehle, Axelle, Dieler, Sandra, Debus, Fabian, Dannhardt, Gerd, Akabas, Myles H., Lüddens, Hartmut

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Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors by Peifer, Christian, Stoiber, Thomas, Unger, Eberhard, Totzke, Frank, Schächtele, Christoph, Marmé, Dieter, Brenk, Ruth, Klebe, Gerhard, Schollmeyer, Dieter, Dannhardt, Gerd

“…The new analogue 2 of combretastatin A-4 was discovered to be an inhibitor of tubulin polymerization with an IC50 of 7.6 μM and reduced angiogenesis in the in…”
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