Search Results - "Dannemann, Michael"

The Contribution of Neanderthals to Phenotypic Variation in Modern Humans by Dannemann, Michael, Kelso, Janet

“…Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for…”
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Something old, something borrowed: admixture and adaptation in human evolution by Dannemann, Michael, Racimo, Fernando

“…The sequencing of ancient DNA from archaic humans—Neanderthals and Denisovans—has revealed that modern and archaic humans interbred at least twice during the…”
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The genomic landscape of Neanderthal ancestry in present-day humans by Sankararaman, Sriram, Mallick, Swapan, Dannemann, Michael, Prüfer, Kay, Kelso, Janet, Pääbo, Svante, Patterson, Nick, Reich, David

“…In the modern human genome, elevated Neanderthal ancestry is found at genes affecting keratin filaments, suggesting that gene flow with Neanderthals helped…”
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Functional implications of Neandertal introgression in modern humans by Dannemann, Michael, Prüfer, Kay, Kelso, Janet

“…Admixture between early modern humans and Neandertals approximately 50,000-60,000 years ago has resulted in 1.5-4% Neandertal ancestry in the genomes of…”
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Detecting ancient positive selection in humans using extended lineage sorting by Peyrégne, Stéphane, Boyle, Michael James, Dannemann, Michael, Prüfer, Kay

“…Natural selection that affected modern humans early in their evolution has likely shaped some of the traits that set present-day humans apart from their…”
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A high-coverage Neandertal genome from Vindija Cave in Croatia by Prüfer, Kay, de Filippo, Cesare, Grote, Steffi, Mafessoni, Fabrizio, Korlević, Petra, Hajdinjak, Mateja, Vernot, Benjamin, Skov, Laurits, Hsieh, Pinghsun, Peyrégne, Stéphane, Reher, David, Hopfe, Charlotte, Nagel, Sarah, Maricic, Tomislav, Fu, Qiaomei, Theunert, Christoph, Rogers, Rebekah, Skoglund, Pontus, Chintalapati, Manjusha, Dannemann, Michael, Nelson, Bradley J., Key, Felix M., Rudan, Pavao, Kućan, Željko, Gušić, Ivan, Golovanova, Liubov V., Doronichev, Vladimir B., Patterson, Nick, Reich, David, Eichler, Evan E., Slatkin, Montgomery, Schierup, Mikkel H., Andrés, Aida M., Kelso, Janet, Meyer, Matthias, Pääbo, Svante

“…To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a…”
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Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals by Vernot, Benjamin, Tucci, Serena, Kelso, Janet, Schraiber, Joshua G., Wolf, Aaron B., Gittelman, Rachel M., Dannemann, Michael, Grote, Steffi, McCoy, Rajiv C., Norton, Heather, Scheinfeldt, Laura B., Merriwether, David A., Koki, George, Friedlaender, Jonathan S., Wakefield, Jon, Pääbo, Svante, Akey, Joshua M.

“…Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors…”
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Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations by Quach, Hélène, Rotival, Maxime, Pothlichet, Julien, Loh, Yong-Hwee Eddie, Dannemann, Michael, Zidane, Nora, Laval, Guillaume, Patin, Etienne, Harmant, Christine, Lopez, Marie, Deschamps, Matthieu, Naffakh, Nadia, Duffy, Darragh, Coen, Anja, Leroux-Roels, Geert, Clément, Frederic, Boland, Anne, Deleuze, Jean-François, Kelso, Janet, Albert, Matthew L., Quintana-Murci, Lluis

“…Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses and their…”
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A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans by Zeberg, Hugo, Dannemann, Michael, Sahlholm, Kristoffer, Tsuo, Kristin, Maricic, Tomislav, Wiebe, Victor, Hevers, Wulf, Robinson, Hugh P.C., Kelso, Janet, Pääbo, Svante

“…The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three…”
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Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance by Schreiweis, Christiane, Bornschein, Ulrich, Burguière, Eric, Kerimoglu, Cemil, Schreiter, Sven, Dannemann, Michael, Goyal, Shubhi, Rea, Ellis, French, Catherine A., Puliyadi, Rathi, Groszer, Matthias, Fisher, Simon E., Mundry, Roger, Winter, Christine, Hevers, Wulf, Pääbo, Svante, Enard, Wolfgang, Graybiel, Ann M.

“…The acquisition of language and speech is uniquely human, but how genetic changes might have adapted the nervous system to this capacity is not well…”
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Quantitative Human Paleogenetics: What can Ancient DNA Tell us About Complex Trait Evolution? by Irving-Pease, Evan K, Muktupavela, Rasa, Dannemann, Michael, Racimo, Fernando

“…Genetic association data from national biobanks and large-scale association studies have provided new prospects for understanding the genetic evolution of…”
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Transcriptional neoteny in the human brain by Somel, Mehmet, Franz, Henriette, Yan, Zheng, Lorenc, Anna, Guo, Song, Giger, Thomas, Kelso, Janet, Nickel, Birgit, Dannemann, Michael, Bahn, Sabine, Webster, Maree J, Weickert, Cynthia S, Lachmann, Michael, Pääbo, Svante, Khaitovich, Philipp

“…In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution,…”
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Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels by André, Mathilde, Brucato, Nicolas, Hudjasov, Georgi, Pankratov, Vasili, Yermakovich, Danat, Montinaro, Francesco, Kreevan, Rita, Kariwiga, Jason, Muke, John, Boland, Anne, Deleuze, Jean-François, Meyer, Vincent, Evans, Nicholas, Cox, Murray P., Leavesley, Matthew, Dannemann, Michael, Org, Tõnis, Metspalu, Mait, Mondal, Mayukh, Ricaut, François-Xavier

“…Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure,…”
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Cell atlas of the regenerating human liver after portal vein embolization by Brazovskaja, Agnieska, Gomes, Tomás, Holtackers, Rene, Wahle, Philipp, Körner, Christiane, He, Zhisong, Schaffer, Theresa, Eckel, Julian Connor, Hänsel, René, Santel, Malgorzata, Seimiya, Makiko, Denecke, Timm, Dannemann, Michael, Brosch, Mario, Hampe, Jochen, Seehofer, Daniel, Damm, Georg, Camp, J. Gray, Treutlein, Barbara

“…The liver has the remarkable capacity to regenerate. In the clinic, regeneration is induced by portal vein embolization, which redirects portal blood flow,…”
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Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans by Chintalapati, Manjusha, Dannemann, Michael, Prüfer, Kay

“…Small insertions and deletions occur in humans at a lower rate compared to nucleotide changes, but evolve under more constraint than nucleotide changes. While…”
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PatMaN: rapid alignment of short sequences to large databases by Prüfer, Kay, Stenzel, Udo, Dannemann, Michael, Green, Richard E., Lachmann, Michael, Kelso, Janet

“…We present a tool suited for searching for many short nucleotide sequences in large databases, allowing for a predefined number of gaps and mismatches. The…”
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High-throughput sequencing of the melanoma genome by Kunz, Manfred, Dannemann, Michael, Kelso, Janet

“…Next‐generation sequencing technologies are now common for whole‐genome, whole‐exome and whole‐transcriptome sequencing (RNA‐seq) of tumors to identify point…”
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A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice by Berger, Claudia, Heyne, Henrike O., Heiland, Tina, Dommel, Sebastian, Höfling, Corinna, Guiu-Jurado, Esther, Lorenz, Jana, Roßner, Steffen, Dannemann, Michael, Kelso, Janet, Kovacs, Peter, Blüher, Matthias, Klöting, Nora

“…The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been…”
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Contesting the presence of wheat in the British Isles 8,000 years ago by assessing ancient DNA authenticity from low-coverage data by Weiß, Clemens L, Dannemann, Michael, Prüfer, Kay, Burbano, Hernán A

“…Contamination with exogenous DNA is a constant hazard to ancient DNA studies, since their validity greatly depend on the ancient origin of the retrieved…”
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Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes by Dannemann, Michael, Milaneschi, Yuri, Yermakovich, Danat, Stiglbauer, Victoria, Kariis, Hanna Maria, Krebs, Kristi, Friese, Manuel A., Otte, Christian, Lehto, Kelli, Penninx, Brenda W. J. H., Kelso, Janet, Gold, Stefan M.

“…Despite advances in identifying the genetic basis of psychiatric and neurological disorders, fundamental questions about their evolutionary origins remain…”
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