Search Results - "Danneman, Michael W"

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines by Danneman, Michael W, Hong, Ki Bum, Johnston, Jeffrey N

“…An operationally straightforward and metal-free inter-/intramolecular oxidative diamination of vinyl aminopyridines is a common gateway to access all four…”
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Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor by Davis, Tyler A, Danneman, Michael W, Johnston, Jeffrey N

“…The first enantioselective synthesis of a potent GlyT1 inhibitor is described. A 3-nitroazetidine donor is used in an enantioselective aza-Henry reaction…”
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Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition by Vara, Brandon A, Mayasundari, Anand, Tellis, John C, Danneman, Michael W, Arredondo, Vanessa, Davis, Tyler A, Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N

“…The finding by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein–protein interaction between p53 and MDM2, thereby inducing…”
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Asymmetric δ‑Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme by Hassan, Isra S, Ta, Angeline N, Danneman, Michael W, Semakul, Natthawat, Burns, Matthew, Basch, Corey H, Dippon, Vanessa N, McNaughton, Brian R, Rovis, Tomislav

“…Reliable design of artificial metalloenzymes (ArMs) to access transformations not observed in nature remains a long-standing and important challenge. We report…”
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Oxidative Inter-/Intermolecular Alkene Diamination of Hydroxy Styrenes with Electron-Rich Amines by Danneman, Michael W, Hong, Ki Bum, Johnston, Jeffrey N

“…Doubly intermolecular alkene diamination is achieved with electron-rich, terminal alkenes through the use of a hypervalent iodine (PhI­(OAc)2) reagent, iodide,…”
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Biomimetic Desymmetrization of a Carboxylic Acid by Knowe, Matthew T, Danneman, Michael W, Sun, Sarah, Pink, Maren, Johnston, Jeffrey N

“…The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94%…”
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Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction by Deng, Zihang, Padalino, Melanie A., Jan, Julius E. L., Park, Sangjun, Danneman, Michael W., Johnston, Jeffrey N.

“…Cracking the selectivity–generality paradox is among the most pressing challenges in asymmetric catalysis. This obstacle prevents the immediate and successful…”
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Tuning through-space interactions via the secondary coordination sphere of an artificial metalloenzyme leads to enhanced Rh( iii )-catalysis by Hassan, Isra S., Fuller, Jack T., Dippon, Vanessa N., Ta, Angeline N., Danneman, Michael W., McNaughton, Brian R., Alexandrova, Anastassia N., Rovis, Tomislav

“…We report computationally-guided protein engineering of monomeric streptavidin Rh( iii ) artificial metalloenzyme to enhance catalysis of the enantioselective…”
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Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy by Schrank, Cassandra L., Danneman, Michael W., Prebihalo, Emily A., Anderson, Robert E., Gibson, Tyler J., Wuest, William M., Mullins, Richard J.

“…[Display omitted] •Chiral auxiliary controlled 1,4-conjugate addition of an allylstannane.•Chiral auxiliary controlled 1,4-conjugate addition of an allyl…”
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Applications of Chiral Amidine Catalysis Towards the Synthesis of Small Molecule Therapeutics and Recent Advances in Vicinal Diamine Synthesis by Danneman, Michael W

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Tuning through-space interactions the secondary coordination sphere of an artificial metalloenzyme leads to enhanced Rh()-catalysis by Hassan, Isra S, Fuller, Jack T, Dippon, Vanessa N, Ta, Angeline N, Danneman, Michael W, McNaughton, Brian R, Alexandrova, Anastassia N, Rovis, Tomislav

“…We report computationally-guided protein engineering of monomeric streptavidin Rh( iii ) artificial metalloenzyme to enhance catalysis of the enantioselective…”
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