ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents

Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Mortality is predominantly related to the occurrence of cerebral oedema; only a minority of deaths in DKA are attributed to other causes. Cerebral oedema occurs in about 0.3–...

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Bibliographic Details
Published in:	Archives of disease in childhood Vol. 89; no. 2; pp. 188 - 194
Main Authors:	Dunger, D B, Sperling, M A, Acerini, C L, Bohn, D J, Daneman, D, Danne, T P A, Glaser, N S, Hanas, R, Hintz, R L, Levitsky, L L, Savage, M O, Tasker, R C, Wolfsdorf, J I
Format:	Journal Article Book Review
Language:	English
Published:	London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01-02-2004 BMJ BMJ Publishing Group Ltd BMJ Publishing Group LTD
Subjects:	Adolescent Adolescents Attrition (Research Studies) Biological and medical sciences Brain Edema - etiology Brain Edema - therapy Child Child, Preschool Children Diabetes diabetic ketoacidosis Diabetic Ketoacidosis - complications Diabetic Ketoacidosis - diagnosis Diabetic Ketoacidosis - drug therapy DKA Eating Disorders ECF Edema Endocrinology ESPE Europe extracellular fluid Fluid Therapy Fluids General aspects GFR glomerular filtration rate Glucose Growth hormones Humans Hyperglycemia ICF ICP Insulin Insulin - therapeutic use intracellular fluid intracranial pressure LWPES Medical sciences Mental Disorders Metabolism Morbidity Mortality Mortality Rate Pediatrics Phosphates - blood Potassium Potassium Deficiency - diagnosis Pregnancy Review Socioeconomic factors Socioeconomic Status Teenagers TIDM type 1 diabetes mellitus Writing Instruction Writing Processes Europe Canada Endocrinopathy Human Pediatrics Metabolic disorder Ketoacidosis Diabetes mellitus Adolescent Acid base balance disorder Review Child
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Summary:	Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Mortality is predominantly related to the occurrence of cerebral oedema; only a minority of deaths in DKA are attributed to other causes. Cerebral oedema occurs in about 0.3–1% of all episodes of DKA, and its aetiology, pathophysiology, and ideal method of treatment are poorly understood. There is debate as to whether physicians treating DKA can prevent or predict the occurrence of cerebral oedema, and the appropriate site(s) for children with DKA to be managed. There is agreement that prevention of DKA and reduction of its incidence should be a goal in managing children with diabetes.
Bibliography:	istex:FBC10A76781BFCEEE2EE56A102B73B147ABB5317 local:0890188 Correspondence to:  Prof. D B Dunger  University of Cambridge, Department of Paediatrics, Addenbrooke’s Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK; dbd25@cam.ac.uk ark:/67375/NVC-4TGLK89J-Q PMID:14736641 href:archdischild-89-188.pdf SourceType-Scholarly Journals-1 ObjectType-News-2 content type line 23 ObjectType-Review-1 ObjectType-Conference-3 ObjectType-Feature-5 ObjectType-Article-4
ISSN:	0003-9888 1468-2044
DOI:	10.1136/adc.2003.044875