Search Results - "Dann, John G"

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs by Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

“…By the use of molecular models of Escherichia coli dihydrofolate reductase (DHFR), analogues of trimethoprim (TMP) were designed which incorporated various…”
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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs by Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

“…The author report here the design, synthesis, DHFR affinity, and X-ray crystallographic binding analysis of a series of 3'-carboxyalkoxy analogues of TMP. At…”
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Dihydrofolate reductase: low-resolution mass-spectrometric analysis of an elastase digest as a sequencing tool by Morris, H R, Batley, K E, Harding, N C, Bjur, R A, Dann, J G, King, R W

“…An elastase digest of a protein of unknown structure, dihydrofolate reductase, was studied by mass spectrometry. This soluble digest contained a large number…”
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