Search Results - "Dann, Geoffrey P"

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation by Liszczak, Glen, Diehl, Katharine L., Dann, Geoffrey P., Muir, Tom W.

“…Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for…”
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A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing by Dao, Hai T., Dul, Barbara E., Dann, Geoffrey P., Liszczak, Glen P., Muir, Tom W.

“…Recent studies have implicated the nucleosome acidic patch in the activity of ATP-dependent chromatin remodeling machines. We used a photocrosslinking-based…”
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Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants by Wojcik, Felix, Dann, Geoffrey P., Beh, Leslie Y., Debelouchina, Galia T., Hofmann, Raphael, Muir, Tom W.

“…Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively…”
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Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries by Nguyen, Uyen T T, Bittova, Lenka, Müller, Manuel M, Fierz, Beat, David, Yael, Houck-Loomis, Brian, Feng, Vanessa, Dann, Geoffrey P, Muir, Tom W

“…A synthetic library of nucleosomes, each with a DNA-barcode characteristic for a defined post-translational modification (PTM), is used to probe PTM-based…”
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Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering by Shah, Neel H, Dann, Geoffrey P, Vila-Perelló, Miquel, Liu, Zhihua, Muir, Tom W

“…We describe the first systematic study of a family of inteins, the split DnaE inteins from cyanobacteria. By measuring in vivo splicing efficiencies and in…”
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JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila by Albig, Christian, Wang, Chao, Dann, Geoffrey P., Wojcik, Felix, Schauer, Tamás, Krause, Silke, Maenner, Sylvain, Cai, Weili, Li, Yeran, Girton, Jack, Muir, Tom W., Johansen, Jørgen, Johansen, Kristen M., Becker, Peter B., Regnard, Catherine

“…In flies, the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from…”
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The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation by McMahon, Conor, Studer, Sean M., Clendinen, Chaevia, Dann, Geoffrey P., Jeffrey, Philip D., Hughson, Frederick M.

“…Coat protein II (COPII)-coated vesicles transport proteins and lipids from the endoplasmic reticulum to the Golgi. Crucial for the initiation of COPII coat…”
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Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes by Mashtalir, Nazar, Dao, Hai T, Sankar, Akshay, Liu, Hengyuan, Corin, Aaron J, Bagert, John D, Ge, Eva J, D'Avino, Andrew R, Filipovski, Martin, Michel, Brittany C, Dann, Geoffrey P, Muir, Tom W, Kadoch, Cigall

“…Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate-dependent chromatin remodelers modulate genomic architecture and gene expression and are frequently mutated…”
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ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference by Dann, Geoffrey P., Liszczak, Glen P., Bagert, John D., Müller, Manuel M., Nguyen, Uyen T. T., Wojcik, Felix, Brown, Zachary Z., Bos, Jeffrey, Panchenko, Tatyana, Pihl, Rasmus, Pollock, Samuel B., Diehl, Katharine L., Allis, C. David, Muir, Tom W.

“…A high-throughput approach using a DNA-barcoded nucleosome library shows that ISWI chromatin remodellers can distinguish between differently modified…”
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Target site specificity and in vivo complexity of the mammalian arginylome by Wang, Junling, Pejaver, Vikas Rao, Dann, Geoffrey P., Wolf, Max Y., Kellis, Manolis, Huang, Yun, Garcia, Benjamin A., Radivojac, Predrag, Kashina, Anna

“…Protein arginylation mediated by arginyltransferase ATE1 is a key regulatory process essential for mammalian embryogenesis, cell migration, and protein…”
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Cereblon target validation using a covalent inhibitor of neosubstrate recruitment by Dann, Geoffrey P, Liu, Hu, Nowak, Radosław P, Jones, Lyn H

“…Small molecule ligands of cereblon (CRBN), a component of an E3 ubiquitin ligase complex, such as immunomodulatory drugs (IMiDs) or proteolysis targeting…”
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Cereblon covalent modulation through structure-based design of histidine targeting chemical probes by Cruite, Justin T, Dann, Geoffrey P, Che, Jianwei, Donovan, Katherine A, Ferrao, Silas, Ficarro, Scott B, Fischer, Eric S, Gray, Nathanael S, Huerta, Fidel, Kong, Nikki R, Liu, Hu, Marto, Jarrod A, Metivier, Rebecca J, Nowak, Rados aw P, Zerfas, Breanna L, Jones, Lyn H

“…Electrophilic biocompatible warheads, particularly cysteine-reactive acrylamides, have enabled the development of covalent inhibitor drugs and chemical biology…”
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Simple Sodium Dodecyl Sulfate-Assisted Sample Preparation Method for LC-MS-Based Proteomics Applications by Zhou, Jian-Ying, Dann, Geoffrey P, Shi, Tujin, Wang, Lu, Gao, Xiaoli, Su, Dian, Nicora, Carrie D, Shukla, Anil K, Moore, Ronald J, Liu, Tao, Camp II, David G, Smith, Richard D, Qian, Wei-Jun

“…Sodium dodecyl sulfate (SDS) is one of the most popular laboratory reagents used for biological sample extraction; however, the presence of this reagent in…”
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Unraveling pancreatic islet biology by quantitative proteomics by Zhou, Jian-Ying, Dann, Geoffrey P, Liew, Chong Wee, Smith, Richard D, Kulkarni, Rohit N, Qian, Wei-Jun

“…The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide…”
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