Search Results - "Danko, David C."
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Ariadne: synthetic long read deconvolution using assembly graphs
Published in Genome Biology (28-08-2023)“…Abstract Synthetic long read sequencing techniques such as UST’s TELL-Seq and Loop Genomics’ LoopSeq combine 3 $$'$$ ′ barcoding with standard short-read…”
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The Microbiomes of Seven Lichen Genera Reveal Host Specificity, a Reduced Core Community and Potential as Source of Antimicrobials
Published in Frontiers in microbiology (24-03-2020)“…The High Andean Paramo ecosystem is a unique neotropical mountain biome considered a diversity and evolutionary hotspot. Lichens, which are complex symbiotic…”
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A comprehensive metagenomics framework to characterize organisms relevant for planetary protection
Published in Microbiome (01-04-2021)“…Clean rooms of the Space Assembly Facility (SAF) at the Jet Propulsion Laboratory (JPL) at NASA are the final step of spacecraft cleaning and assembly before…”
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Minerva: an alignment- and reference-free approach to deconvolve Linked-Reads for metagenomics
Published in Genome research (01-01-2019)“…Emerging Linked-Read technologies (aka read cloud or barcoded short-reads) have revived interest in short-read technology as a viable approach to understand…”
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Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections
Published in Journal of bone and joint surgery. American volume (15-09-2021)“…Over 1 million Americans undergo joint replacement each year, and approximately 1 in 75 will incur a periprosthetic joint infection. Effective treatment…”
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System-wide transcriptome damage and tissue identity loss in COVID-19 patients
Published in Cell reports. Medicine (15-02-2022)“…The molecular mechanisms underlying the clinical manifestations of coronavirus disease 2019 (COVID-19), and what distinguishes them from common seasonal…”
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Characterizing the Urban Microbiome and Human Response to the Ecosystem of the Built Environment
Published 01-01-2021“…The urban environment contains a diverse set of microorganisms that survive on surfaces and suspended in the air. Using metagenomics and related technologies…”
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Dissertation -
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322. Clinical-Grade Metagenomics in Urinary Tract Infections: Improving Performance of Next-Generation Sequencing Assays Using Internal Controls and Machine Learning
Published in Open forum infectious diseases (15-12-2022)“…Abstract Background Shotgun sequencing-based metagenomics is a useful approach to profiling microbiomes in environmental and patient samples. In a clinical…”
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Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections
Published in Journal of bone and joint surgery. American volume (22-07-2021)Get full text
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2835. Utilization of Clinical-Grade Metagenomics in Urinary Tract Infection Diagnostics: Improving High-Risk Patients’ Outcomes with a Genomic-Based Assay
Published in Open forum infectious diseases (27-11-2023)“…Abstract Background Immunosuppressed patients and those experiencing complicated UTIs are more susceptible to misdiagnosis by outdated standard of care (SOC)…”
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The MetaSUB Microbiome Core Analysis Pipeline Enables Large Scale Metagenomic Analysis
Published 25-09-2020“…Motivation: Accurate data analysis and quality control is critical for metagenomic studies. Though many tools exist to analyze metagenomic data there is no…”
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The Challenges and Opportunities in Creating an Early Warning System for Global Pandemics
Published 01-02-2023“…The COVID-19 pandemic revealed that global health, social systems, and economies can be surprisingly fragile in an increasingly interconnected and…”
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Journal Article