High-frequency oscillations (>200 Hz) in the human non-parkinsonian subthalamic nucleus

Abstract The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's...

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Bibliographic Details
Published in:	Brain research bulletin Vol. 74; no. 1; pp. 84 - 90
Main Authors:	Danish, S.F, Moyer, J.T, Finkel, L.H, Baltuch, G.H, Jaggi, J.L, Priori, A, Foffani, G
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14-09-2007
Subjects:	Aged DBS Deep brain stimulation Deep Brain Stimulation - methods Dystonia - physiopathology Female High-frequency oscillations High-Frequency Ventilation Human Humans Middle Aged Neurology STN Subthalamic nucleus Subthalamic Nucleus - physiopathology Tremor - physiopathology Human High-frequency oscillations Subthalamic nucleus DBS STN Deep brain stimulation
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Summary:	Abstract The human basal ganglia, and in particular the subthalamic nucleus (STN), can oscillate at surprisingly high frequencies, around 300 Hz [G. Foffani, A. Priori, M. Egidi, P. Rampini, F. Tamma, E. Caputo, K.A. Moxon, S. Cerutti, S. Barbieri, 300-Hz subthalamic oscillations in Parkinson's disease, Brain 126 (2003) 2153–2163]. It has been proposed that these oscillations could contribute to the mechanisms of action of deep brain stimulation (DBS) [G. Foffani, A. Priori, Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm, Brain 129 (2006) E59]. However, the physiological role of high-frequency STN oscillations is questionable, because they have been observed only in patients with advanced Parkinson's disease and could therefore be secondary to the dopamine-depleted parkinsonian state. Here, we report high-frequency STN oscillations in the range of the 300-Hz rhythm during intraoperative microrecordings for DBS in an awake patient with focal dystonia as well as in a patient with essential tremor (ET). High-frequency STN oscillations are therefore not exclusively related to parkinsonian pathophysiology, but may represent a broader feature of human STN function.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2007.05.006