Search Results - "Danis, Clement"

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody by Albert, Marie, Mairet-Coello, Georges, Danis, Clément, Lieger, Sarah, Caillierez, Raphaëlle, Carrier, Sébastien, Skrobala, Emilie, Landrieu, Isabelle, Michel, Anne, Schmitt, Mathieu, Citron, Martin, Downey, Patrick, Courade, Jean-Philippe, Buée, Luc, Colin, Morvane

“…Tauopathies are neurodegenerative diseases characterized by the intraneuronal accumulation of aggregated tau. The staging of this neurodegenerative process is…”
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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment by Danis, Clément, Dupré, Elian, Zejneli, Orgeta, Caillierez, Raphaëlle, Arrial, Alexis, Bégard, Séverine, Mortelecque, Justine, Eddarkaoui, Sabiha, Loyens, Anne, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Buée, Luc, Landrieu, Isabelle

“…Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of…”
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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor by Carvalho, Kevin, Faivre, Emilie, Pietrowski, Marie J., Marques, Xavier, Gomez-Murcia, Victoria, Deleau, Aude, Huin, Vincent, Hansen, Jan N, Kozlov, Stanislav, Danis, Clément, Temido Ferreira, Mariana, Coelho, Joana, Mériaux, Céline, Eddarkaoui, Sabiha, Gras, Stéphanie Le, Dumoulin, Mélanie, Cellai, Lucrezia, Landrieu, Isabelle, Chern, Yijuang, Hamdane, Malika, Buée, Luc, Boutillier, Anne-Laurence, Levi, Sabine, Halle, Annett, Lopes, Luisa, Blum, David

“…© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms…”
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Aggregate-selective removal of pathological tau by clustering-activated degraders by Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel E, Vaysburd, Marina J, Böken, Dorothea, Miller, Lauren V C, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo C, McEwan, William A

“…Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase tripartite…”
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Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies by Leroux, Elodie, Perbet, Romain, Caillierez, Raphaëlle, Richetin, Kevin, Lieger, Sarah, Espourteille, Jeanne, Bouillet, Thomas, Bégard, Séverine, Danis, Clément, Loyens, Anne, Toni, Nicolas, Déglon, Nicole, Deramecourt, Vincent, Schraen-Maschke, Susanna, Buée, Luc, Colin, Morvane

“…Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. Seed-competent tau species have been suggested to spread from cell…”
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A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein by Mortelecque, Justine, Zejneli, Orgeta, Bégard, Séverine, Simões, Margarida C., ElHajjar, Lea, Nguyen, Marine, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Gomes, Cláudio M., Buée, Luc, Landrieu, Isabelle, Danis, Clément, Dupré, Elian

“…The use of variable domain of the heavy-chain of the heavy-chain-only antibodies (VHHs) as disease-modifying biomolecules in neurodegenerative disorders holds…”
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Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies by Dupré, Elian, Danis, Clément, Arrial, Alexis, Hanoulle, Xavier, Homa, Mégane, Cantrelle, François-Xavier, Merzougui, Hamida, Colin, Morvane, Rain, Jean-Christophe, Buée, Luc, Landrieu, Isabelle

“…Tau is a neuronal protein linked to pathologies called tauopathies, including Alzheimer’s disease. In Alzheimer’s disease, tau aggregates into filaments,…”
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Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus by Fogeron, Marie-Laure, Jirasko, Vlastimil, Penzel, Susanne, Paul, David, Montserret, Roland, Danis, Clément, Lacabanne, Denis, Badillo, Aurélie, Gouttenoire, Jérôme, Moradpour, Darius, Bartenschlager, Ralf, Penin, François, Meier, Beat H., Böckmann, Anja

“…We describe the expression of the hepatitis C virus nonstructural protein 4B (NS4B), which is an integral membrane protein, in a wheat germ cell-free system,…”
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Gradient reconstitution of membrane proteins for solid-state NMR studies by Lacabanne, Denis, Lends, Alons, Danis, Clément, Kunert, Britta, Fogeron, Marie-Laure, Jirasko, Vlastimil, Chuilon, Claire, Lecoq, Lauriane, Orelle, Cédric, Chaptal, Vincent, Falson, Pierre, Jault, Jean-Michel, Meier, Beat H., Böckmann, Anja

“…We here adapted the GRecon method used in electron microscopy studies for membrane protein reconstitution to the needs of solid-state NMR sample preparation…”
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Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications by Danis, Clément, Dupré, Elian, Hanoulle, Xavier, Landrieu, Isabelle, Lasorsa, Alessia, Neves, João Filipe, Schneider, Robert, Smet-Nocca, Caroline

“…Although Tau is an intrinsically disordered protein, some level of structure can still be defined, corresponding to short stretches of dynamic secondary…”
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Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins by Danis, Clément, Despres, Clément, Bessa, Luiza M, Malki, Idir, Merzougui, Hamida, Huvent, Isabelle, Qi, Haoling, Lippens, Guy, Cantrelle, François-Xavier, Schneider, Robert, Hanoulle, Xavier, Smet-Nocca, Caroline, Landrieu, Isabelle

“…Aggregates of the neuronal Tau protein are found inside neurons of Alzheimer's disease patients. Development of the disease is accompanied by increased,…”
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Recombinant Production and Characterization of VHHs/Nanobodies Targeting Tau to Block Fibrillar Assembly by Mortelecque, Justine, Danis, Clément, Landrieu, Isabelle, Dupré, Elian

“…Tau protein was extensively studied using nuclear magnetic resonance spectroscopy, providing a powerful way to determine interaction sites between Tau and…”
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Aggregate-selective removal of pathological tau via clustering-activated degraders by Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel, Vaysburd, Marina, Böken, Dorothea, Miller, Lauren, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo, Mcewan, William

“…Homotypic protein assembly is a critical mediator of biological function and disease state. Selective degradation of protein assemblies, while sparing…”
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PREVENTION OF TAU SEEDING AND SPREADING IN TRANSGENIC MOUSE MODELS BASED ON INTRACRANIAL-INJECTION OF P301L-K18 FIBRILS OR ALZHEIMER’S DISEASE LYSATE BY PASSIVE IMMUNOTHERAPY by Albert, Marie, Caillierez, Raphaelle, Danis, Clément, Lieger, Sarah, Bégard, Séverine, Mairet-Coello, Georges, Courade, Jean-Philippe, Citron, Martin, Buee, Luc, Colin, Morvane

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O4‐05‐05: PREVENTION OF TAU SEEDING AND SPREADING IN TRANSGENIC MOUSE MODELS BASED ON INTRACRANIAL‐INJECTION OF P301L‐K18 FIBRILS OR ALZHEIMER'S DISEASE LYSATE BY PASSIVE IMMUNOTHERAPY by Albert, Marie, Caillierez, Raphaelle, Danis, Clément, Lieger, Sarah, Bégard, Séverine, Mairet-Coello, Georges, Courade, Jean-Philippe, Citron, Martin, Buee, Luc, Colin, Morvane

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Nanobodies (VHHs) for targeting tau in Alzheimer's disease and tauopathies by Buee, Luc, Danis, Clement, Dupre, Elian, Arrial, Alexis, Cantrelle, François-Xavier, Rain, Jean-Christophe, Colin, Morvane, Hanoulle, Xavier, Landrieu, Isabelle

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Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins by Danis, Clément, Despres, Clément, Bessa, Luiza M., Malki, Idir, Merzougui, Hamida, Huvent, Isabelle, Qi, Haoling, Lippens, Guy, Cantrelle, François-Xavier, Schneider, Robert, Hanoulle, Xavier, Smet-Nocca, Caroline, Landrieu, Isabelle

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