Search Results - "Danielson, Matthew"

Computer-aided drug design platform using PyMOL by Lill, Markus A., Danielson, Matthew L.

“…The understanding and optimization of protein-ligand interactions are instrumental to medicinal chemists investigating potential drug candidates. Over the past…”
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Anthropogenic biases in chemical reaction data hinder exploratory inorganic synthesis by Jia, Xiwen, Lynch, Allyson, Huang, Yuheng, Danielson, Matthew, Lang’at, Immaculate, Milder, Alexander, Ruby, Aaron E., Wang, Hao, Friedler, Sorelle A., Norquist, Alexander J., Schrier, Joshua

“…Most chemical experiments are planned by human scientists and therefore are subject to a variety of human cognitive biases 1 , heuristics 2 and social…”
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The staggered retreat of grounded ice in the Ross Sea, Antarctica, since the Last Glacial Maximum (LGM) by Danielson, Matthew A, Bart, Philip J

“…The retreat of the West Antarctic Ice Sheet (WAIS) in the Ross Sea after the Last Glacial Maximum (LGM) was more significant than for any other Antarctic…”
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Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases by Jiang, Qing, Yin, Xinmin, Lill, Markus A, Danielson, Matthew L, Freiser, Helene, Huang, Jianjie

“…Cyclooxygenase (COX-1/COX-2)-catalyzed eicosanoid formation plays a key role in inflammation-associated diseases. Natural forms of vitamin E are recently shown…”
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In Silico and in Vitro Assessment of OATP1B1 Inhibition in Drug Discovery by Danielson, Matthew L, Sawada, Geri A, Raub, Thomas J, Desai, Prashant V

“…The organic anion-transporting polypeptide 1B1 transporter belongs to the solute carrier superfamily and is highly expressed at the basolateral membrane of…”
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Predicting flexible loop regions that interact with ligands: The challenge of accurate scoring by Danielson, Matthew L., Lill, Markus A.

“…Flexible loop regions play a critical role in the biological function of many proteins and have been shown to be involved in ligand binding. In the context of…”
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New computational method for prediction of interacting protein loop regions by Danielson, Matthew L., Lill, Markus A.

“…Flexible loop regions of proteins play a crucial role in many biological functions such as protein–ligand recognition, enzymatic catalysis, and protein–protein…”
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Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structures by Danielson, Matthew L., Desai, Prashant V., Mohutsky, Michael A., Wrighton, Steven A., Lill, Markus A.

“…Cytochrome P450 enzymes are responsible for metabolizing many endogenous and xenobiotic molecules encountered by the human body. It has been estimated that 75%…”
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Evaluation of Short-term and Long-term Complications after Emergent Internal Iliac Artery Embolization in Patients with Pelvic Trauma by Travis, Talitha, MD, Monsky, Wayne L., MD, PhD, London, Jason, MD, MPH, Danielson, Matthew, MD, Brock, John, BS, Wegelin, Jacob, PhD, Link, Daniel P., MD

“…Purpose To assess the incidence of long- and short-term complications following internal iliac artery (IIA) embolization after blunt pelvic trauma. Materials…”
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Chronic hyperoxia augments the hypoxic ventilatory response in adult rats by Danielson, Matthew, Bavis, Ryan

“…Abstract only Chronic hyperoxia during postnatal development causes long-lasting attenuation of the hypoxic ventilatory response (HVR) in rats, but similar…”
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Beyond the Target Customer: Social Effects of Customer Relationship Management Campaigns by ASCARZA, EVA, EBBES, PETER, NETZER, ODED, DANIELSON, MATTHEW

“…Customer relationship management (CRM) campaigns have traditionally focused on maximizing the profitability of the targeted customers. The authors demonstrate…”
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Hidden Markov Models with Variational Inference in Marketing Science by Danielson, Matthew

“…Hidden Markov Models (HMMs) are a well known type of model for many varieties of sequen- tial data. There exist several algorithms for learning HMMs: a variant…”
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Topographic Control on Post-LGM Groundings of the West Antarctic Ice Sheet in the Whales Deep Basin, Eastern Ross Sea by Danielson, Matthew

“…By the peak of the Last Glacial Maximum (LGM), the West Antarctic Ice Sheet (WAIS) had advanced to the outer continental shelf of eastern Ross Sea trough…”
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Protein flexibility in computer-aided drug discovery: predicting correlated loop conformations and drug metabolism by CYP2C9 by Danielson, Matthew L

“…Protein flexibility is critical to the molecular recognition process between a protein and a ligand. Flexible loop regions have been shown to play a crucial…”
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Protein flexibility in computer-aided drug discovery: predicting correlated loop conformations and drug metabolism by CYP2C9 by Danielson, Matthew L

“…Protein flexibility is critical to the molecular recognition process between a protein and a ligand. Flexible loop regions have been shown to play a crucial…”
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