Search Results - "Daniels, Stephen E"

A phase 3, randomized, placebo-controlled trial of DepoFoam® bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy by Golf, Michael, Daniels, Stephen E., Onel, Erol

“…Background DepoFoam® bupivacaine (Pacira Pharmaceuticals, Inc., San Diego, CA, USA), an extended-release liposomal bupivacaine-based analgesic, was compared…”
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Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial by Daniels, Stephen E., Atkinson, Hartley C., Stanescu, Ioana, Frampton, Chris

“…Acute pain is a significant burden to the individual and to society. There is a clear need for a pain medication that provides improved analgesia over common…”
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Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: A randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study by Mehlisch, Donald R., MD, DDS, Aspley, Sue, PhD, Daniels, Stephen E., DO, Bandy, Donald P., DDS

“…Abstract Background: Combination analgesics may offer improved analgesic efficacy, particularly for moderate to severe pain. Objective: This study evaluated…”
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A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: A multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study by Mehlisch, Donald R., MD, DDS, Aspley, Sue, PhD, Daniels, Stephen E., DO, Southerden, Kristin A., MS, Christensen, Kyle S., DDS

“…Abstract Background: The combination of ibuprofen and paracetamol may confer analgesic benefits over monotherapy with either agent. In a previous study, an…”
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Cardiovascular safety of hydroxypropyl-β-cyclodextrin–diclofenac in the management of acute postsurgical pain: a pooled analysis of 2 randomized, double-blind, placebo- and active comparator–controlled phase III clinical trials by Gan, Tong J., MD, MHS, FRCA, Singla, Neil, MD, Daniels, Stephen E., DO, Lacouture, Peter G., PhD, Min, Lauren H., PharmD, Reyes, Christian R.D., MS, Carr, Daniel B., MD

“…Abstract Study Objective Long-term use of nonsteroidal anti-inflammatory drugs, including selective and nonselective cyclooxygenase inhibitors, has been…”
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Evaluation of the Dose Range of Etoricoxib in an Acute Pain Setting Using the Postoperative Dental Pain Model by Daniels, Stephen E, Bandy, Donald P, Christensen, Steven E, Boice, Judith, Losada, Maria C, Liu, Hui, Mehta, Anish, Peloso, Paul M

“…OBJECTIVEThis study was conducted to evaluate the dose range of etoricoxib in acute pain using the postoperative dental pain model further. METHODSThis…”
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Efficacy and Safety of an Intravenous Acetaminophen/Ibuprofen Fixed-dose Combination After Bunionectomy: a Randomized, Double-blind, Factorial, Placebo-controlled Trial by Daniels, Stephen E., Playne, Rebecca, Stanescu, Ioana, Zhang, Jennifer, Gottlieb, Ira J., Atkinson, Hartley C.

“…Multimodal analgesia with acetaminophen and/or nonsteroidal anti-inflammatory drugs is recommended for the treatment of postoperative pain. Although oral…”
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The analgesic efficacy of valdecoxib vs. oxycodone/acetaminophen after oral surgery by Daniels, Stephen E, Desjardins, Paul J, Talwalker, Sheela, Recker, David P, Verburg, Kenneth M

“…The authors conducted two studies to compare the analgesic efficacy and safety of the cyclooxygenase, or COX, -2-specific inhibitor, valdecoxib, with…”
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Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study by Daniels, Stephen E., Paredes-Diaz, A., An, R., Centofanti, R., Tajaddini, Azita

“…Objectives: Many women experience menstrual cramps, which adversely affects quality-of-life. Both naproxen and acetaminophen are indicated to relieve menstrual…”
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A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain by Daniels, Stephen E., Upmalis, David, Okamoto, Akiko, Lange, Claudia, Häeussler, Jüergen

“…ABSTRACT Objective: This study evaluated tapentadol immediate release (IR) for pain relief following orthopedic bunionectomy surgery. Methods: This randomized,…”
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A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain by Daniels, Stephen E., Goulder, Michael A., Aspley, Sue, Reader, Sandie

“…Combination analgesia is often recommended for the relief of severe pain. This was a double-blind, 5-arm, parallel-group, placebo-controlled, randomised,…”
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A randomized, double-blind, celecoxib- and placebo-controlled study of the effectiveness of CS-706 in acute postoperative dental pain by Moberly, James B., PhD, Xu, Jianbo, MS, Desjardins, Paul J., DMD, PhD, Daniels, Stephen E., DO, Bandy, Donald P., DDS, Lawson, Janet E., PhD, Link, Allison J., BS, Truitt, Kenneth E., MD

“…Abstract Background: CS-706 is a cyclooxygenase-2 (COX-2)-selective inhibitor with an in vitro selectivity ratio (COX-1:COX-2) similar to that of celecoxib. It…”
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Tolerability of intramuscular and intradermal delivery by CELLECTRA® adaptive constant current electroporation device in healthy volunteers by Diehl, Malissa C, Lee, Jessica C, Daniels, Stephen E, Tebas, Pablo, Khan, Amir S, Giffear, Mary, Sardesai, Niranjan Y, Bagarazzi, Mark L

“…DNA vaccines are being developed as a potentially safe and effective immunization platform. However, translation of DNA vaccines into a clinical setting has…”
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Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventional Hydrocodone 7.5 mg/Acetaminophen 325 mg by Zuniga, John R, Papas, Athena S, Daniels, Stephen E, Patrick, Kyle, Muse, Derek D, Oreadi, Daniel, Giannakopoulos, Helen E, Granquist, Eric J, Levin, Lawrence M, Chou, Joli C, Maibach, Hilda, Schachtel, Bernard P

“…Abstract Objectives To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel…”
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Novel p38α Mitogen-Activated Protein Kinase Inhibitor Shows Analgesic Efficacy in Acute Postsurgical Dental Pain by Tong, Sandra E., Daniels, Stephen E., Black, Peter, Chang, Stephen, Protter, Andrew, Desjardins, Paul J.

“…SCIO-469 is a selective p38α mitogen-activated protein kinase (MAPK) inhibitor for preclinical models of acute pain. This prospective, double-blind, randomized…”
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A Novel Injectable Formulation of Diclofenac Compared with Intravenous Ketorolac or Placebo for Acute Moderate-to-Severe Pain After Abdominal or Pelvic Surgery: A Multicenter, Double-Blind, Randomized, Multiple-Dose Study by Gan, Tong J., Daniels, Stephen E., Singla, Neil, Hamilton, Douglas A., Carr, Daniel B.

“…Injectable formulations of diclofenac have long been available in Europe and other countries. These formulations use a default dose of 75 mg of diclofenac…”
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A Double-Blind Randomized Controlled Trial of Rofecoxib and Multidose Oxycodone/Acetaminophen in Dental Impaction Pain by Desjardins, Paul J., DMD, PhD, Black, Peter M., MS, Daniels, Stephen E., DO, Bird, Steven R., MS, Petruschke, Richard A., PharmD, Chang, David J., MD, Smugar, Steven S., MD, Tershakovec, Andrew M., MD

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A Pooled Analysis Evaluating Renal Safety in Placebo- and Active Comparator-Controlled Phase III Trials of Multiple-Dose Injectable HPβCD-Diclofenac in Subjects with Acute Postoperative Pain by Daniels, Stephen E., Gan, Tong J. (TJ), Hamilton, Douglas A., Singla, Neil, Lacouture, Peter G., Johnson, Olufunmibi, Min, Lauren H., Reyes, Christian R. D., Carr, Daniel B.

“…Objective. While injectable nonsteroidal anti-inflammatory drugs (NSAIDs) are a key component of postoperative multimodal analgesia, renal safety concerns may…”
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A Phase 2 Study of Lower-dose, Indomethacin Submicron Particle Capsules Demonstrates Early Onset of Acute Pain Relief by Manvelian, Garen, Hochberg, Marc C, Daniels, Stephen E, Altman, Roy D, Young, Clarence L

“…OBJECTIVES:Nonsteroidal anti-inflammatory drugs are efficacious for the treatment of acute and chronic pain; however, they have the potential for serious…”
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A Pooled Analysis Evaluating Renal Safety in Placebo- and Active Comparator-Controlled Phase III Trials of Multiple-Dose Injectable HPβCD-Diclofenac in Subjects with Acute Postoperative Pain by Daniels, Stephen E, Gan, Tong J Tj, Hamilton, Douglas A, Singla, Neil, Lacouture, Peter G, Johnson, Olufunmibi, Min, Lauren H, Reyes, Christian R D, Carr, Daniel B

“…OBJECTIVE : While injectable nonsteroidal anti-inflammatory drugs (NSAIDs) are a key component of postoperative multimodal analgesia, renal safety concerns may…”
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