Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats

Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats

Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral pretreatment of rats with bimoclomol could elevate myocardial HSP70 and reduce infarct size in a rat model of ischemia and reperfusion . Rat...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 435; no. 1; pp. 79 - 83
Main Authors: Lubbers, Nathan L, Polakowski, James S, Wegner, Craig D, Burke, Sandra E, Diaz, Gilbert J, Daniell, Katina M, Cox, Bryan F
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 18-01-2002
Elsevier
Subjects:
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Disease Models, Animal
Heart Rate - drug effects
Heat shock protein 70
HSP70 Heat-Shock Proteins - metabolism
Imides - therapeutic use
Infarct size
Ischemia
Medical sciences
Miscellaneous
Myocardial Infarction - physiopathology
Myocardial Infarction - prevention & control
Myocardium - metabolism
Pharmacology. Drug treatments
Protective Agents - therapeutic use
Pyridines - therapeutic use
Rats
Reperfusion
Heat shock protein 70
Infarct size
Reperfusion
Ischemia
Infarct
Treatment efficiency
Bimoclomol
Cardioprotective agent
Oral administration
Cardiovascular disease
Coronary heart disease
Myocardial disease
Biological activity
Chemotherapy
Treatment
Heat shock protein
Myocardium
Antiïschemic
Mechanism of action
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Summary:Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral pretreatment of rats with bimoclomol could elevate myocardial HSP70 and reduce infarct size in a rat model of ischemia and reperfusion . Rats were pretreated with bimoclomol at 3, 6 or 18 h or with 42° thermal stress 24 h before ischemia. Infarct size was significantly decreased 6 h after oral administration of bimoclomol and 24 h after thermal stress. Left ventricles from a separate group of rats were examined for HSP70 levels. Western blots showed a significant increase in HSP70 6 h after oral administration of bimoclomol and 24 h after thermal stress. There was a significant correlation ( P<0.05) between HSP70 induction and infarct size reduction, whether produced by thermal stress or oral administration of bimoclomol. Thus, bimoclomol can increase HSP70 and reduce infarct size in a rat model of ischemia and reperfusion.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(01)01552-7