Search Results - "Daniel Sauter"

Key Viral Adaptations Preceding the AIDS Pandemic by Sauter, Daniel, Kirchhoff, Frank

“…HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes…”
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Furin‐mediated protein processing in infectious diseases and cancer by Braun, Elisabeth, Sauter, Daniel

“…Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a…”
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Counteraction of the multifunctional restriction factor tetherin by Sauter, Daniel

“…The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1.24) has emerged as a key component of the antiviral immune response…”
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Antiviral mechanisms of guanylate-binding protein 5: versatile inhibition of multiple viral glycoproteins by Sauter, Daniel, Kirchhoff, Frank

“…Guanylate-binding proteins (GBPs) are interferon-inducible cellular factors known to inhibit a wide variety of pathogens. Humans encode seven GBPs that have…”
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Not all viruses cause disease: HERV-K(HML-2) in healthy human tissues by Srinivasachar Badarinarayan, Smitha, Sauter, Daniel

“…Human endogenous retroviruses (HERVs) make up a significant part of our genome. While their expression is frequently associated with disease, a new study in…”
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Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity by Sauter, Daniel, Kirchhoff, Frank

“…Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG…”
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SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant by Konno, Yoriyuki, Kimura, Izumi, Uriu, Keiya, Fukushi, Masaya, Irie, Takashi, Koyanagi, Yoshio, Sauter, Daniel, Gifford, Robert J., Nakagawa, So, Sato, Kei

“…One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-CoV is the presence of premature stop codons in its ORF3b gene. Here,…”
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Sarbecovirus ORF6 proteins hamper induction of interferon signaling by Kimura, Izumi, Konno, Yoriyuki, Uriu, Keiya, Hopfensperger, Kristina, Sauter, Daniel, Nakagawa, So, Sato, Kei

“…The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other…”
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Evolutionary conflicts and adverse effects of antiviral factors by Sauter, Daniel, Kirchhoff, Frank

“…Human cells are equipped with a plethora of antiviral proteins protecting them against invading viral pathogens. In contrast to apoptotic or pyroptotic cell…”
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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro by Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank

“…Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- and anti-viral activities have been reported for…”
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Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors by Lotke, Rishikesh, Petersen, Moritz, Sauter, Daniel

“…The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food,…”
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pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer by Sauter, Daniel R.P., Sørensen, Christiane E., Rapedius, Markus, Brüggemann, Andrea, Novak, Ivana

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and new therapeutic targets are urgently needed. One of the hallmarks of cancer is…”
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Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities by Hayn, Manuel, Hirschenberger, Maximilian, Koepke, Lennart, Nchioua, Rayhane, Straub, Jan Hendrik, Klute, Susanne, Hunszinger, Victoria, Zech, Fabian, Prelli Bozzo, Caterina, Aftab, Wasim, Christensen, Maria Hønholt, Conzelmann, Carina, Müller, Janis Alexander, Srinivasachar Badarinarayan, Smitha, Stürzel, Christina Martina, Forne, Ignasi, Stenger, Steffen, Conzelmann, Karl-Klaus, Münch, Jan, Schmidt, Florian Ingo, Sauter, Daniel, Imhof, Axel, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate immune responses but may still be vulnerable to some. Here, we systematically…”
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Emerging Role of the Host Restriction Factor Tetherin in Viral Immune Sensing by Hotter, Dominik, Sauter, Daniel, Kirchhoff, Frank

“…Tetherin (BST-2, CD317) is an interferon-inducible cellular factor that inhibits the release of diverse enveloped viruses by tethering them to the cell…”
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Decreased, Deformed, Defective-How HIV-1 Vpu Targets Peroxisomes by Hopfensperger, Kristina, Sauter, Daniel

“…Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons…”
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Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity by Krapp, Christian, Hotter, Dominik, Gawanbacht, Ali, McLaren, Paul J., Kluge, Silvia F., Stürzel, Christina M., Mack, Katharina, Reith, Elisabeth, Engelhart, Susanne, Ciuffi, Angela, Hornung, Veit, Sauter, Daniel, Telenti, Amalio, Kirchhoff, Frank

“…Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine triphosphatases (GTPases) with well-established activity against…”
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SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans by Nchioua, Rayhane, Kmiec, Dorota, Müller, Janis A, Conzelmann, Carina, Groß, Rüdiger, Swanson, Chad M, Neil, Stuart J D, Stenger, Steffen, Sauter, Daniel, Münch, Jan, Sparrer, Konstantin M J, Kirchhoff, Frank

“…Recent evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sensitive to interferons (IFNs). However, the most effective types…”
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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation by Hotter, Dominik, Bosso, Matteo, Jønsson, Kasper L., Krapp, Christian, Stürzel, Christina M., Das, Atze, Littwitz-Salomon, Elisabeth, Berkhout, Ben, Russ, Alina, Wittmann, Sabine, Gramberg, Thomas, Zheng, Yue, Martins, Laura J., Planelles, Vicente, Jakobsen, Martin R., Hahn, Beatrice H., Dittmer, Ulf, Sauter, Daniel, Kirchhoff, Frank

“…The interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA intermediates. We show that IFI16 restricts HIV-1 independently…”
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Validating Automatic Concept-Based Explanations for AI-Based Digital Histopathology by Sauter, Daniel, Lodde, Georg, Nensa, Felix, Schadendorf, Dirk, Livingstone, Elisabeth, Kukuk, Markus

“…Digital histopathology poses several challenges such as label noise, class imbalance, limited availability of labelled data, and several latent biases to deep…”
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Ignition of the southern Atlantic seafloor spreading machine without hot-mantle booster by Sauter, Daniel, Manatschal, Gianreto, Kusznir, Nick, Masquelet, Charles, Werner, Philippe, Ulrich, Marc, Bellingham, Paul, Franke, Dieter, Autin, Julia

“…The source of massive magma production at volcanic rifted margins remains strongly disputed since the first observations of thick lava piles in the 1980s…”
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