Search Results - "Daniel R. Morales"

Metformin in Cancer Treatment and Prevention by Morales, Daniel R, Morris, Andrew D

“…Patients with diabetes mellitus are at increased risk of cancer development. Metformin is a well-established, effective agent for the management of type 2…”
Get full text

Exclusion rates in randomized controlled trials of treatments for physical conditions: a systematic review by He, Jinzhang, Morales, Daniel R, Guthrie, Bruce

“…The generalisability of randomized controlled trials (RCTs) can be uncertain because the impact of exclusion criteria is rarely quantified. The aim of this…”
Get full text

Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: systematic review of observational studies and methodological considerations by Morales, Daniel R, Slattery, Jim, Evans, Stephen, Kurz, Xavier

“…Antidepressant exposure during pregnancy has been associated with an increased risk of autism spectrum disorder (ASD) and attention deficit hyperactivity…”
Get full text

The impact of varying the number and selection of conditions on estimated multimorbidity prevalence: A cross-sectional study using a large, primary care population dataset by MacRae, Clare, McMinn, Megan, Mercer, Stewart W, Henderson, David, McAllister, David A, Ho, Iris, Jefferson, Emily, Morales, Daniel R, Lyons, Jane, Lyons, Ronan A, Dibben, Chris, Guthrie, Bruce

“…Multimorbidity prevalence rates vary considerably depending on the conditions considered in the morbidity count, but there is no standardised approach to the…”
Get full text

Studying the Impact of European Union Regulatory Interventions for Minimising Risks From Medicines: Lessons Learnt and Recommendations by Goedecke, Thomas, Martirosyan, Liana, Gault, Nathalie, Seifert, Karin, Morales, Daniel R., Bahri, Priya, Strassmann, Valerie, Huber, Martin, Straus, Sabine

“…ABSTRACT Purpose The European Medicines Agency's (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) launched a strategy to examine the public health…”
Get full text

Low uptake of palliative care for COPD patients within primary care in the UK by Bloom, Chloe I, Slaich, Bhavan, Morales, Daniel R, Smeeth, Liam, Stone, Patrick, Quint, Jennifer K

“…Mortality and symptom burden from chronic obstructive pulmonary disease (COPD) and lung cancer are similar but there is thought to be an inequality in…”
Get full text

Patient outcomes following AKI and AKD: a population-based cohort study by Wang, Huan, Lambourg, Emilie, Guthrie, Bruce, Morales, Daniel R, Donnan, Peter T, Bell, Samira

“…Background Acute kidney injury (AKI) is common and associated with adverse outcomes as well as important healthcare costs. However, evidence examining the…”
Get full text

External validation of the QLifetime cardiovascular risk prediction tool: population cohort study by Livingstone, Shona, Morales, Daniel R, Fleuriot, Jacques, Donnan, Peter T, Guthrie, Bruce

“…Prediction of lifetime cardiovascular disease (CVD) risk is recommended in many clinical guidelines, but lifetime risk models are rarely externally validated…”
Get full text

Predictive performance of a competing risk cardiovascular prediction tool CRISK compared to QRISK3 in older people and those with comorbidity: population cohort study by Livingstone, Shona J, Guthrie, Bruce, Donnan, Peter T, Thompson, Alexander, Morales, Daniel R

“…Recommended cardiovascular disease (CVD) prediction tools do not account for competing mortality risk and over-predict incident CVD in older and multimorbid…”
Get full text

Respiratory effect of beta‐blocker eye drops in asthma: population‐based study and meta‐analysis of clinical trials by Morales, Daniel R., Dreischulte, Tobias, Lipworth, Brian J., Donnan, Peter T., Jackson, Cathy, Guthrie, Bruce

“…Aims To measure the prevalence of beta‐blocker eye drop prescribing and respiratory effect of ocular beta‐blocker administration in people with asthma. Methods…”
Get full text

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials by Morales, Daniel R., MBChB, Lipworth, Brian J., MD, Guthrie, Bruce, PhD, Jackson, Cathy, MD, Donnan, Peter T., PhD, Santiago, Virginia H., MBBM

“…Background Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory…”
Get full text

Assessing the impact of a national clinical guideline for the management of chronic pain on opioid prescribing rates: a controlled interrupted time series analysis by Hébert, Harry L, Morales, Daniel R, Torrance, Nicola, Smith, Blair H, Colvin, Lesley A

“…Opioids can be effective analgesics, but long-term use may be associated with harms. In 2013, the first national, comprehensive, evidence-based pain management…”
Get full text

Health conditions in adults with HIV compared with the general population: A population-based cross-sectional analysis by Morales, Daniel R., Moreno-Martos, David, Matin, Nashaba, McGettigan, Patricia

“…Life expectancy in adults with human immunodeficiency virus (HIV) has increased and managing other health conditions is increasingly important for patients and…”
Get full text

Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011 by Guthrie, Bruce, Clark, Stella A, Reynish, Emma L, McCowan, Colin, Morales, Daniel R

“…Regulatory risk communications are an important method for disseminating drug safety information, but their impact varies. Two significant UK risk…”
Get full text

Intolerance to Angiotensin Converting Enzyme Inhibitors in Asthma and the General Population: A UK Population-Based Cohort Study by Morales, Daniel R., Lipworth, Brian J., Donnan, Peter T., Wang, Huan

“…Angiotensin converting enzyme inhibitor (ACEI) intolerance commonly occurs, requiring switching to an angiotensin-II receptor blocker (ARB). Angiotensin…”
Get full text

Effect of competing mortality risks on predictive performance of the QRISK3 cardiovascular risk prediction tool in older people and those with comorbidity: external validation population cohort study by Livingstone, Shona, Morales, Daniel R, Donnan, Peter T, Payne, Katherine, Thompson, Alexander J, Youn, Ji-Hee, Guthrie, Bruce

“…Primary prevention of cardiovascular disease (CVD) is guided by risk-prediction tools, but these rarely account for the risk of dying from other conditions…”
Get full text

Effect of competing mortality risks on predictive performance of the QFracture-2012 risk prediction tool for major osteoporotic fracture and hip fracture: external validation cohort study in a UK primary care population by Livingstone, Shona J, Morales, Daniel R, McMinn, Megan, Eke, Chima, Donnan, Peter, Guthrie, Bruce

“…ObjectiveTo externally evaluate the QFracture-2012 risk prediction tool for predicting the risk of major osteoporotic fracture and hip fracture.DesignExternal…”
Get full text

How to validate a diagnosis recorded in electronic health records by Nissen, Francis, Quint, Jennifer K, Morales, Daniel R, Douglas, Ian J

“…http://ow.ly/iHQ630np4xU…”
Get full text

Effect of Differentiated Injection Ratio, Gas Flow Rate, and Slag Thickness on Mixing Time and Open Eye Area in Gas-Stirred Ladle Assisted by Physical Modeling by Jardón-Pérez, Luis E., González-Morales, Daniel R., Trápaga, Gerardo, González-Rivera, Carlos, Ramírez-Argáez, Marco A.

“…In this work, the effects of equal (50%/50%) or differentiated (75%/25%) gas flow ratio, gas flow rate, and slag thickness on mixing time and open eye area…”
Get full text

Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis by Morales, Daniel R., Macfarlane, Tatiana, MacDonald, Thomas M., Hallas, Jesper, Ernst, Martin Thomsen, Herings, Ron M. C., Smits, Elisabeth, Overbeek, Jetty A., Mitchell, Lyn, Morant, Steven, Mackenzie, Isla, Doney, Alexander S. F., Robertson, Chris, Bennie, Marion, Wei, Li, Nicholson, Lizzie, Morris, Carole, Flynn, Robert W. F.

“…Background Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that…”
Get full text