Search Results - "Daniel L. Galvan"

The hallmarks of mitochondrial dysfunction in chronic kidney disease by Galvan, Daniel L, Green, Nathanael H, Danesh, Farhad R

“…Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria…”
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Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy by Ayanga, Bernard A, Badal, Shawn S, Wang, Yin, Galvan, Daniel L, Chang, Benny H, Schumacker, Paul T, Danesh, Farhad R

“…Mitochondrial fission has been linked to the pathogenesis of diabetic nephropathy (DN). However, how mitochondrial fission affects progression of DN in vivo is…”
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Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice by Galvan, Daniel L, Long, Jianyin, Green, Nathanael, Chang, Benny H, Lin, Jamie S, Schumacker, Paul, Truong, Luan D, Overbeek, Paul, Danesh, Farhad R

“…Phosphorylation of Dynamin-related protein1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here we established the role of Drp1…”
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NDUFS4 regulates cristae remodeling in diabetic kidney disease by Mise, Koki, Long, Jianyin, Galvan, Daniel L., Ye, Zengchun, Fan, Guizhen, Sharma, Rajesh, Serysheva, Irina I., Moore, Travis I., Jeter, Collene R., Anna Zal, M., Araki, Motoo, Wada, Jun, Schumacker, Paul T., Chang, Benny H., Danesh, Farhad R.

“…The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated…”
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Publisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease by Mise, Koki, Long, Jianyin, Galvan, Daniel L., Ye, Zengchun, Fan, Guizhen, Sharma, Rajesh, Serysheva, Irina I., Moore, Travis I., Jeter, Collene R., Anna Zal, M., Araki, Motoo, Wada, Jun, Schumacker, Paul T., Chang, Benny H., Danesh, Farhad R.

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PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites by Li, Li, Long, Jianyin, Mise, Koki, Galvan, Daniel L., Overbeek, Paul A., Tan, Lin, Kumar, Shwetha V., Chan, Wai Kin, Lorenzi, Phillip L., Chang, Benny H., Danesh, Farhad R.

“…lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its…”
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Mitochondrial Regulation of Diabetic Kidney Disease by Galvan, Daniel L, Mise, Koki, Danesh, Farhad R

“…The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial…”
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Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model by Galvan, Daniel L, O'Neil, Richard T, Foster, Aaron E, Huye, Leslie, Bear, Adham, Rooney, Cliona M, Wilson, Matthew H

“…Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used…”
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PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer by Saridey, Sai K, Liu, Li, Doherty, Joseph E, Kaja, Aparna, Galvan, Daniel L, Fletcher, Bradley S, Wilson, Matthew H

“…Somatic cell gene transfer has permitted inducible gene expression in vivo through coinfection of multiple viruses. We hypothesized that the highly efficient…”
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T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC by Szoor, Arpad, Vaidya, Abishek, Velasquez, Mireya Paulina, Mei, Zhuyong, Galvan, Daniel L., Torres, David, Gee, Adrian, Heczey, Andras, Gottschalk, Stephen

“…The outcome for advanced stage hepatocellular carcinoma (HCC) remains poor, highlighting the need for novel therapies. Genetically modified mesenchymal stem…”
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MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma by Green, Nathanael H., Galvan, Daniel L., Badal, Shawn S., Chang, Benny H., LeBleu, Valerie S., Long, Jianyin, Jonasch, Eric, Danesh, Farhad R.

“…One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular…”
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Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy by Galvan, Daniel L, Badal, Shawn S, Long, Jianyin, Chang, Benny H, Schumacker, Paul T, Overbeek, Paul A, Danesh, Farhad R

“…While increased mitochondrial reactive oxygen species have been commonly implicated in a variety of disease states, their in vivo role in the pathogenesis of…”
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Comparative analysis of chimeric ZFP-, TALE- and Cas9-piggyBac transposases for integration into a single locus in human cells by Luo, Wentian, Galvan, Daniel L, Woodard, Lauren E, Dorset, Dan, Levy, Shawn, Wilson, Matthew H

“…Integrating DNA delivery systems hold promise for many applications including treatment of diseases; however, targeted integration is needed for improved…”
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Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1 by Long, Jianyin, Galvan, Daniel L., Mise, Koki, Kanwar, Yashpal S., Li, Li, Poungavrin, Naravat, Overbeek, Paul A., Chang, Benny H., Danesh, Farhad R.

“…Long noncoding RNAs (lncRNAs) have been shown to play key roles in a variety of biological activities of the cell. However, less is known about how lncRNAs…”
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Paradoxical Role of IL-17 in Progression of Diabetic Nephropathy by Galvan, Daniel L, Danesh, Farhad R

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Shaping Up Mitochondria in Diabetic Nephropathy by Mise, Koki, Galvan, Daniel L, Danesh, Farhad R

“…Mitochondrial medicine has experienced significant progress in recent years and is expected to grow significantly in the near future, yielding many…”
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Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy by Long, Jianyin, Badal, Shawn S, Ye, Zengchun, Wang, Yin, Ayanga, Bernard A, Galvan, Daniel L, Green, Nathanael H, Chang, Benny H, Overbeek, Paul A, Danesh, Farhad R

“…The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome…”
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RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice by Durham, William J., Aracena-Parks, Paula, Long, Cheng, Rossi, Ann E., Goonasekera, Sanjeewa A., Boncompagni, Simona, Galvan, Daniel L., Gilman, Charles P., Baker, Mariah R., Shirokova, Natalia, Protasi, Feliciano, Dirksen, Robert, Hamilton, Susan L.

“…Mice with a malignant hyperthermia mutation (Y522S) in the ryanodine receptor (RyR1) display muscle contractures, rhabdomyolysis, and death in response…”
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Carboxyl-terminal Sequences Critical for Inositol 1,4,5-Trisphosphate Receptor Subunit Assembly by Galvan, Daniel L, Mignery, Gregory A

“…The inositol 1,4,5-trisphosphate receptor (InsP 3 R) is a tetrameric assembly of conserved subunits that each contains six transmembrane regions (TMRs)…”
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Genome-wide Mapping of PiggyBac Transposon Integrations in Primary Human T Cells by GALVAN, Daniel L, NAKAZAWA, Yozo, KAJA, Aparna, KETTLUN, Claudia, COOPER, Laurence J. N, ROONEY, Cliona M, WILSON, Matthew H

“…The piggyBac transposon system represents a promising nonviral tool for gene delivery and discovery, and may also be of value for clinical gene therapy…”
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