Search Results - "Daniel J. Leonard"

Asymmetric α-arylation of amino acids by Leonard, Daniel J., Ward, John W., Clayden, Jonathan

“…Quaternary amino acids, in which the α-carbon that bears the amino and carboxyl groups also carries two carbon substituents, have an important role as…”
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Amino Acid-Derived trans-N‑Chloroformylimidazolidinones: Scalable, Stereoselective Synthesis, Structure, and Utility by Amer, Mostafa Mahmoud, Abas, Hossay, Leonard, Daniel J, Ward, John W, Clayden, Jonathan

“…N-acyl imidazolidinones, which are key intermediates in the stereoselective synthesis of amino acids by “self-regeneration of stereochemistry” methods, are…”
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Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α‑Amino Acids by Amer, Mostafa M, Carrasco, Ana C, Leonard, Daniel J, Ward, John W, Clayden, Jonathan

“…Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler–Napieralski-style…”
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Scalable synthesis and coupling of quaternary α-arylated amino acids: α-aryl substituents are tolerated in α-helical peptides by Leonard, Daniel J, Zieleniewski, Francis, Wellhöfer, Isabelle, Baker, Emily G, Ward, John W, Woolfson, Derek N, Clayden, Jonathan

“…Quaternary amino acids are important tools for the modification and stabilisation of peptide secondary structures. Here we describe a practical and scalable…”
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Glucose-sensitive insulin with attenuation of hypoglycaemia by Hoeg-Jensen, Thomas, Kruse, Thomas, Brand, Christian L., Sturis, Jeppe, Fledelius, Christian, Nielsen, Peter K., Nishimura, Erica, Madsen, Alice R., Lykke, Lennart, Halskov, Kim S., Koščová, Simona, Kotek, Vladislav, Davis, Anthony P., Tromans, Robert A., Tomsett, Michael, Peñuelas-Haro, Guillem, Leonard, Daniel J., Orchard, Michael G., Chapman, Andy, Invernizzi, Gaetano, Johansson, Eva, Granata, Daniele, Hansen, Bo F., Pedersen, Thomas A., Kildegaard, Jonas, Pedersen, Karen-Margrethe, Refsgaard, Hanne H. F., Alifrangis, Lene, Fels, Johannes J., Neutzsky-Wulff, Anita V., Sauerberg, Per, Slaaby, Rita

“…The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes 1 , 2 . Insulin doses must…”
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‘Reverse biomimetic’ synthesis of l -arogenate and its stabilized analogues from l -tyrosine by Eagling, Louise, Leonard, Daniel J., Schwarz, Maria, Urruzuno, Iñaki, Boden, Grace, Wailes, J. Steven, Ward, John W., Clayden, Jonathan

“…l -Arogenate (also known as l -pretyrosine) is a primary metabolite on a branch of the shikimate biosynthetic pathway to aromatic amino acids. It plays a key…”
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Intramolecular arylation of amino acid enolates by Atkinson, Rachel C, Leonard, Daniel J, Maury, Julien, Castagnolo, Daniele, Volz, Nicole, Clayden, Jonathan

“…Dianionic enolates formed from N'-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N'-aryl ring,…”
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Self-Reflected Well-Being via a Smartphone App in Clinical Medical Students: Feasibility Study by Berryman, Elizabeth K, Leonard, Daniel J, Gray, Andrew R, Pinnock, Ralph, Taylor, Barry

“…Well-being in medical students has become an area of concern, with a number of studies reporting high rates of clinical depression, anxiety, burnout, and…”
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Asymmetric -arylation of amino acids by Leonard, Daniel J, Ward, John W, Clayden, Jonathan

“…Quaternary amino acids, in which the [alpha]-carbon that bears the amino and carboxyl groups also carries two carbon substituents, have an important role as…”
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Orchestrating PP2A Holoenzyme Assembly: From Normal to Abnormal and the Therapeutic Opportunity in Between by Leonard, Daniel J

“…Reversible protein phosphorylation is perhaps the most abundant mechanism of communication through which cells regulate proteins to guide cellular processes in…”
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Aeroacoustic measurements in a vocal tract model by Leonard, Daniel J., Krane, Michael

“…An experiment to clarify the relation between turbulent jet structure, vocal tract wall shape and the resulting sound is described. A life-scale model of the…”
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Exploring Opportunities for Malting Barley Production in Florida by Charles E. Barrett, Lincoln Zotarelli, Sylvia M. Willis, Jay M. Capasso, Ethan T. Carter, De Broughton, Kevin R. Athearn, Andrew MacIntosh, Alicia N Halbritter, Matthew T. Smith, Kevin A. Korus, Daniel J. Leonard

“…This new 6-page publication of the UF/IFAS Horticultural Sciences Department aims to inform Florida growers and the craft brewing and distillery industry about…”
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'Reverse biomimetic' synthesis of -arogenate and its stabilized analogues from -tyrosine by Eagling, Louise, Leonard, Daniel J, Schwarz, Maria, Urruzuno, Iñaki, Boden, Grace, Wailes, J. Steven, Ward, John W, Clayden, Jonathan

“…l -Arogenate (also known as l -pretyrosine) is a primary metabolite on a branch of the shikimate biosynthetic pathway to aromatic amino acids. It plays a key…”
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Computation and analysis of cavitating flow in Francis-class hydraulic turbines by Leonard, Daniel J

“…Hydropower is the most proven renewable energy technology, supplying the world with 16% of its electricity. Conventional hydropower generates a vast majority…”
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Computation and analysis of cavitating flow in Francis-class hydraulic turbines by Leonard, Daniel J

“…Hydropower is the most proven renewable energy technology, supplying the world with 16% of its electricity. Conventional hydropower generates a vast majority…”
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Islanding experience at a petroleum processing cogeneration facility by Leonard, Daniel J., Patil, Tushar J., Xinggang Bai, Pulavarthi, Vijay K., Riaz, Nabil, Zahrani, Yousef A.

“…This paper examines the control of combustion turbine generators to maintain stability when transitioning from interconnected operation to islanded operation…”
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Coordination of a distribution level continuously controlled compensation device with existing substation equipment for long term VAr management by Paserba, J.J., Leonard, D.J., Miller, N.W., Naumann, S.T., Lauby, M.G., Sener, F.P.

“…The implementation of a continuously-controlled reactive compensation device, such as an SVC or a "static condenser" (STATCON), in a distribution-level…”
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Resupply of High Pressure Oxygen and Nitrogen Tanks for Extra-Atmospheric Station and Bases by Cook, Anthony J., Leonard, Daniel J., O'Donnell, Patricia A.

“…The Shuttle retirement in 2010 will force the ISS program to reconsider how to supply the Station with nitrogen and oxygen for six to ten more years beyond…”
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Perioperative statins: More than lipid-lowering? by Feldman, Leonard S, Brotman, Daniel J

“…Preliminary evidence indicates that statin drugs may be beneficial when given in the perioperative period. Although more studies are needed to draw firm…”
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Determination of On-Orbit Cabin Air Loss from the International Space Station (ISS) by Williams, David E., Leonard, Daniel J., Smith, Patrick J.

“…The International Space Station (ISS) loses cabin atmosphere mass at some rate. Due to oxygen partial pressures fluctuations from metabolic usage, the total…”
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