Search Results - "Daniel, Todd E"

Discovery, Synthesis, and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3 by Goodfellow, Val S, Loweth, Colin J, Ravula, Satheesh B, Wiemann, Torsten, Nguyen, Thong, Xu, Yang, Todd, Daniel E, Sheppard, David, Pollack, Scott, Polesskaya, Oksana, Marker, Daniel F, Dewhurst, Stephen, Gelbard, Harris A

“…Inhibition of mixed lineage kinase 3 (MLK3) is a potential strategy for treatment of Parkinson’s disease and HIV-1 associated neurocognitive disorders (HAND),…”
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Association of mesenteric volvulus in police working dogs with and without a prior prophylactic laparoscopic gastropexy by Fruehwald, Christina M, Spector, Daniel I, Daniel, Todd E

“…To evaluate the association of mesenteric volvulus (MV) in New York Police Department police working dogs (PWDs) with and without a prior prophylactic…”
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N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia by Welch, M, Todd, D.E, Whitehead, N, McGowan, S.J, Bycroft, B.W, Salmond, G.P.C

“…Quorum sensing via an N‐acyl homoserine lactone (HSL) pheromone controls the biosynthesis of a carbapenem antibiotic in Erwinia carotovora. Transcription of…”
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Carbapenem antibiotic biosynthesis in Erwinia carotovora is regulated by physiological and genetic factors modulating the quorum sensing‐dependent control pathway by McGowan, Simon J., Barnard, Anne M. L., Bosgelmez, Gulgun, Sebaihia, Mohammed, Simpson, Natalie J. L., Thomson, Nicholas R., Todd, Daniel E., Welch, Martin, Whitehead, Neil A., Salmond, George P. C.

“…Summary Erwinia carotovora produces the β‐lactam antibiotic, carbapenem, in response to a quorum sensing signalling molecule, N‐(3‐oxohexanoyl)‐ l‐homoserine…”
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Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3′-kinase (PI3K) pathway is inhibited by MOLTON, Sarah A, TODD, Daniel E, COOK, Simon J

“…c-Jun N-terminal kinase (JNK) is activated when cells are exposed to noxious stimuli. The role of JNK in apoptosis is subject to considerable debate; for…”
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Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010-2020) by Hildebrandt, Isabella M, Skinner, Owen T, Mickelson, Megan A, Daniel, Todd E, Ashworth, Hayley L, Kim, Annie, Wustefeld-Janssens, Brandan G, Martin, Tiffany W, McKenna, Charly, Oblak, Michelle L, Poirier, Valerie J, Randhawa, Karanbir, Turek, Michelle M, McAnulty, Jonathan F, Griffin, Maureen A, Duda, Lillian E, Mendez Valenzuela, Carlos R, Vanhaezebrouck, Isabelle F, Sterman, Allyson A, Bloom, Christopher, Selmic, Laura E, Fu, Dah-Renn, Gutti, Jishnu Rao, Nagata, Koichi, Thomsen, Brian, Vinayak, Arathi, Jenei, Beatrix, Maitz, Charles A

“…To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS)…”
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Boot Camp To Improve Student Perception and Performance in Sophomore Organic Chemistry? Hoorah by Siebert, Matthew R, Daniel, Todd E, High, Brian D

“…The sophomore organic chemistry sequence (Organic I and II) has a reputation: one that has prospective students worried. Their anxiety is well-founded, given…”
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Outcome and postoperative complications in 73 dogs with thyroid carcinoma with gross vascular invasion managed with thyroidectomy by Latifi, Max, Skinner, Owen T., Spoldi, Elisa, Ackerman, Leah, Souza, Carlos H. De M., Yoon, Jin, Vinayak, Arathi, Tuohy, Joanne L., Wallace, Mandy L., Dornbusch, Josephine A., Selmic, Laura E., Menard, Jenna, Sumner, Julia P., Schrock, Kelly C., Wustefeld‐Janssens, Brandan G., Matz, Brad M., Daniel, Todd E., Mickelson, Megan A.

“…Excellent outcomes have been reported following thyroidectomy for thyroid carcinoma in dogs, but outcomes for thyroid carcinomas with gross vascular invasion…”
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Does Hands-on Guarding Influence Performance on the Functional Gait Assessment? by Shaw, Jason L., Robinson, Barbara S., Himes, Marcia K., Daniel, Todd E., Holland, Lydia J., Mosley, Geoff D., Kraft, Claire M., Mulcahey, Rachel L.

“…An accurate fall risk assessment is an important component of fall prevention, though a fall could occur during testing. To minimize this risk, different…”
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ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover by Densham, Ruth M., Todd, Daniel E., Balmanno, Kathy, Cook, Simon J.

“…The conditional kinase ΔMEKK3:ER⁎ allows activation of JNK, p38 and ERK1/2 without overt cellular stress or damage and has proved useful in understanding how…”
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ΔMEKK3:ER activation induces a p38α/β2-dependent cell cycle arrest at the G2 checkpoint by GARNER, Andrew P, WESTON, Claire R, TODD, Daniel E, BALMANNO, Kathryn, COOK, Simon J

“…Whilst many studies have examined the role of the MAP Kinases in regulating the G1→S transition, much less is known about the function of these pathways in…”
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Do Lower Extremity Strength and Lower Extremity Blood Flow Predict the Score on the Functional Gait Assessment in Patients Enrolled in Phase II Cardiac Rehabilitation? by Himes, Marcia K., Moore, Elizabeth S., Robinson, Barbara S., Daniel, Todd E.

“…Purpose: Fall prevention, and the reduction of fall-related injuries, is critically important for preserving independence among older adults. Phase II cardiac…”
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Selective activation of the c-Jun N-terminal kinase pathway is inhibited by Molton, Sarah A, Todd, Daniel E, Cook, Simon J

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The conditional kinase DeltaMEKK1:ER selectively activates the JNK pathway and protects against serum withdrawal-induced cell death by Molton, Sarah A, Weston, Claire, Balmanno, Kathryn, Newson, Catherine, Todd, Daniel E, Garner, Andrew P, Cook, Simon J

“…The conditional protein kinase DeltaMEKK3:ER* allows activation of the mitogen-activated and stress-activated protein kinases (MAPKs and SAPKs) without…”
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The conditional kinase ΔMEKK1:ER selectively activates the JNK pathway and protects against serum withdrawal-induced cell death by Molton, Sarah A., Weston, Claire, Balmanno, Kathryn, Newson, Catherine, Todd, Daniel E., Garner, Andrew P., Cook, Simon J.

“…The conditional protein kinase ΔMEKK3:ER* allows activation of the mitogen-activated and stress-activated protein kinases (MAPKs and SAPKs) without imposing a…”
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ΔMEKK3:ER activation induces a p38α/β2-dependent cell cycle arrest at the G2checkpoint by Garner, Andrew P, Weston, Claire R, Todd, Daniel E, Balmanno, Kathryn, Cook, Simon J

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[Delta]MEKK3:ER activation induces a p38[alpha]/[beta]2-dependent cell cycle arrest at the G2 checkpoint by Garner, Andrew P, Weston, Claire R, Todd, Daniel E, Balmanno, Kathryn, Cook, Simon J

“…Whilst many studies have examined the role of the MAP Kinases in regulating the G1-->S transition, much less is known about the function of these pathways in…”
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Delta MEKK3:ER activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint by Garner, Andrew P, Weston, Claire R, Todd, Daniel E, Balmanno, Kathryn, Cook, Simon J

“…Whilst many studies have examined the role of the MAP Kinases in regulating the G1-->S transition, much less is known about the function of these pathways in…”
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ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest by TODD, Daniel E, DENSHAM, Ruth M, MOLTON, Sarah A, BALMANNO, Kathryn, NEWSON, Catherine, WESTON, Claire R, GARNER, Andrew P, SCOTT, Linda, COOK, Simon J

“…To study the mechanisms by which mitogen- and stress-activated protein kinases regulate cell cycle re-entry, we have used a panel of conditional kinases that…”
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