Search Results - "Daniel, Stover"

Chemotherapy-Exacerbated Breast Cancer Metastasis: A Paradox Explainable by Dysregulated Adaptive-Response by Middleton, Justin D, Stover, Daniel G, Hai, Tsonwin

“…An emerging picture in cancer biology is that, paradoxically, chemotherapy can actively induce changes that favor cancer progression. These pro-cancer changes…”
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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer by Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J., Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G., Lim, Elgene, Wang, Zhigang C., Iglehart, J. Dirk, Young, Richard A., Gray, Nathanael S., Zhao, Jean J.

“…Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a…”
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Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells by Bierie, Brian, Pierce, Sarah E., Kroeger, Cornelia, Stover, Daniel G., Pattabiraman, Diwakar R., Thiru, Prathapan, Donaher, Joana Liu, Reinhardt, Ferenc, Chaffer, Christine L., Keckesova, Zuzana, Weinberg, Robert A.

“…Neoplastic cells within individual carcinomas often exhibit considerable phenotypic heterogeneity in their epithelial versus mesenchymal-like cell states…”
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A global Fine-Root Ecology Database to address below-ground challenges in plant ecology by Iversen, Colleen M., McCormack, M. Luke, Powell, A. Shafer, Blackwood, Christopher B., Freschet, Grégoire T., Kattge, Jens, Roumet, Catherine, Stover, Daniel B., Soudzilovskaia, Nadejda A., Valverde‐Barrantes, Oscar J., Bodegom, Peter M., Violle, Cyrille

“…Summary Variation and tradeoffs within and among plant traits are increasingly being harnessed by empiricists and modelers to understand and predict ecosystem…”
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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance by Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.

“…Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a…”
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BRAF and AXL oncogenes drive RIPK3 expression loss in cancer by Najafov, Ayaz, Zervantonakis, Ioannis K, Mookhtiar, Adnan K, Greninger, Patricia, March, Ryan J, Egan, Regina K, Luu, Hoang Son, Stover, Daniel G, Matulonis, Ursula A, Benes, Cyril H, Yuan, Junying

“…Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3…”
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Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial by Jiang, Yi-Zhou, Liu, Yin, Xiao, Yi, Hu, Xin, Jiang, Lin, Zuo, Wen-Jia, Ma, Ding, Ding, Jiahan, Zhu, Xiaoyu, Zou, Jianjun, Verschraegen, Claire, Stover, Daniel G., Kaklamani, Virginia, Wang, Zhong-Hua, Shao, Zhi-Ming

“…Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular subtyping may result in improved diagnostic precision and targeted…”
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CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer by Johnson, Shawn F., Cruz, Cristina, Greifenberg, Ann Katrin, Dust, Sofia, Stover, Daniel G., Chi, David, Primack, Benjamin, Cao, Shiliang, Bernhardy, Andrea J., Coulson, Rhiannon, Lazaro, Jean-Bernard, Kochupurakkal, Bose, Sun, Heather, Unitt, Christine, Moreau, Lisa A., Sarosiek, Kristopher A., Scaltriti, Maurizio, Juric, Dejan, Baselga, José, Richardson, Andrea L., Rodig, Scott J., D’Andrea, Alan D., Balmaña, Judith, Johnson, Neil, Geyer, Matthias, Serra, Violeta, Lim, Elgene, Shapiro, Geoffrey I.

“…Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired…”
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ASO Author Reflections: Disparities in Oncologic Surgery: The Problem We All Live with by Obeng-Gyasi, Samilia, Stover, Daniel G.

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Socioeconomic and Surgical Disparities are Associated with Rapid Relapse in Patients with Triple-Negative Breast Cancer by Obeng-Gyasi, Samilia, Asad, Sarah, Fisher, James L., Rahurkar, Saurabh, Stover, Daniel G.

“…Background A subset of triple-negative breast cancer (TNBC) is characterized by aggressive disease, rapid relapse, and mortality within 24 months of diagnosis,…”
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The Immune Microenvironment in Hormone Receptor-Positive Breast Cancer Before and After Preoperative Chemotherapy by Waks, Adrienne G, Stover, Daniel G, Guerriero, Jennifer L, Dillon, Deborah, Barry, William T, Gjini, Evisa, Hartl, Christina, Lo, Wesley, Savoie, Jennifer, Brock, Jane, Wesolowski, Robert, Li, Zaibo, Damicis, Adrienne, Philips, Anne V, Wu, Yun, Yang, Fei, Sullivan, Amy, Danaher, Patrick, Brauer, Heather Ann, Osmani, Wafa, Lipschitz, Mikel, Hoadley, Katherine A, Goldberg, Michael, Perou, Charles M, Rodig, Scott, Winer, Eric P, Krop, Ian E, Mittendorf, Elizabeth A, Tolaney, Sara M

“…Hormone receptor-positive/HER2-negative (HR /HER2 ) breast cancer is associated with low levels of stromal tumor-infiltrating lymphocytes (sTIL) and PD-L1, and…”
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Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer by Stover, Daniel G, Parsons, Heather A, Ha, Gavin, Freeman, Samuel S, Barry, William T, Guo, Hao, Choudhury, Atish D, Gydush, Gregory, Reed, Sarah C, Rhoades, Justin, Rotem, Denisse, Hughes, Melissa E, Dillon, Deborah A, Partridge, Ann H, Wagle, Nikhil, Krop, Ian E, Getz, Gad, Golub, Todd R, Love, J Christopher, Winer, Eric P, Tolaney, Sara M, Lin, Nancy U, Adalsteinsson, Viktor A

“…Purpose Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide profiling of tumor alterations without tumor biopsy and may be associated…”
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A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA by Doebley, Anna-Lisa, Ko, Minjeong, Liao, Hanna, Cruikshank, A. Eden, Santos, Katheryn, Kikawa, Caroline, Hiatt, Joseph B., Patton, Robert D., De Sarkar, Navonil, Collier, Katharine A., Hoge, Anna C. H., Chen, Katharine, Zimmer, Anat, Weber, Zachary T., Adil, Mohamed, Reichel, Jonathan B., Polak, Paz, Adalsteinsson, Viktor A., Nelson, Peter S., MacPherson, David, Parsons, Heather A., Stover, Daniel G., Ha, Gavin

“…Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework…”
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Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer by Sceneay, Jaclyn, Goreczny, Gregory J, Wilson, Kristin, Morrow, Sara, DeCristo, Molly J, Ubellacker, Jessalyn M, Qin, Yuanbo, Laszewski, Tyler, Stover, Daniel G, Barrera, Victor, Hutchinson, John N, Freedman, Rachel A, Mittendorf, Elizabeth A, McAllister, Sandra S

“…Immune checkpoint blockade (ICB) therapy, which targets T cell-inhibitory receptors, has revolutionized cancer treatment. Among the breast cancer subtypes,…”
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Percutaneous Ultrasonic Tenotomy Reduces Insertional Achilles Tendinopathy Pain With High Patient Satisfaction and a Low Complication Rate by Chimenti, Ruth L., Stover, Daniel W., Fick, Benjamin S., Hall, Mederic M.

“…Due to the novelty of percutaneous ultrasonic tenotomy, the risks and benefits of this minimally invasive procedure for insertional Achilles tendinopathy pain…”
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Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer by Parsons, Heather A, Rhoades, Justin, Reed, Sarah C, Gydush, Gregory, Ram, Priyanka, Exman, Pedro, Xiong, Kan, Lo, Christopher C, Li, Tianyu, Fleharty, Mark, Kirkner, Gregory J, Rotem, Denisse, Cohen, Ofir, Yu, Fangyan, Fitarelli-Kiehl, Mariana, Leong, Ka Wai, Hughes, Melissa E, Rosenberg, Shoshana M, Collins, Laura C, Miller, Kathy D, Blumenstiel, Brendan, Trippa, Lorenzo, Cibulskis, Carrie, Neuberg, Donna S, DeFelice, Matthew, Freeman, Samuel S, Lennon, Niall J, Wagle, Nikhil, Ha, Gavin, Stover, Daniel G, Choudhury, Atish D, Getz, Gad, Winer, Eric P, Meyerson, Matthew, Lin, Nancy U, Krop, Ian, Love, J Christopher, Makrigiorgos, G Mike, Partridge, Ann H, Mayer, Erica L, Golub, Todd R, Adalsteinsson, Viktor A

“…Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for…”
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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases by Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J

“…In mouse models of patient-derived breast cancer brain metastases, combined inhibition of PI3K and mTOR resulted in regression, and therapeutic response was…”
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FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA by Liu, Yaping, Reed, Sarah C., Lo, Christopher, Choudhury, Atish D., Parsons, Heather A., Stover, Daniel G., Ha, Gavin, Gydush, Gregory, Rhoades, Justin, Rotem, Denisse, Freeman, Samuel, Katz, David W., Bandaru, Ravi, Zheng, Haizi, Fu, Hailu, Adalsteinsson, Viktor A., Kellis, Manolis

“…Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite…”
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Stress-Inducible Gene Atf3 Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization by Middleton, Justin D, Fehlman, Jared, Sivakumar, Subhakeertana, Stover, Daniel G, Hai, Tsonwin

“…Previously, we showed that chemotherapy paradoxically exacerbated cancer cell colonization at the secondary site in a manner dependent on , a stress-inducible…”
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Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer by Basree, Mustafa M, Shinde, Neelam, Koivisto, Christopher, Cuitino, Maria, Kladney, Raleigh, Zhang, Jianying, Stephens, Julie, Palettas, Marilly, Zhang, Allen, Kim, Hee Kyung, Acero-Bedoya, Santiago, Trimboli, Anthony, Stover, Daniel G, Ludwig, Thomas, Ganju, Ramesh, Weng, Daniel, Shields, Peter, Freudenheim, Jo, Leone, Gustavo W, Sizemore, Gina M, Majumder, Sarmila, Ramaswamy, Bhuvaneswari

“…A large collaborative analysis of data from 47 epidemiological studies concluded that longer duration of breastfeeding reduces the risk of developing breast…”
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