Search Results - "Daniel, Steffi"

Protocol for In Vivo Evaluation and Use of Destabilizing Domains in the Eye, Liver, and Beyond by Ramadurgum, Prerana, Daniel, Steffi, Hulleman, John D.

“…Destabilizing domains (DDs) have been used successfully to conditionally control the abundance of proteins of interest (POIs) in a small-molecule-dependent…”
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Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging by Peng, Hui, Ramadurgum, Prerana, Woodard, DaNae R., Daniel, Steffi, Nakahara, Emi, Renwick, Marian, Aredo, Bogale, Datta, Shyamtanu, Chen, Bo, Ufret-Vincenty, Rafael, Hulleman, John D.

“…The Escherichia coli dihydrofolate reductase (DHFR) destabilizing domain (DD) serves as a promising approach to conditionally regulate protein abundance in a…”
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Exploring ocular fibulin-3 (EFEMP1): Anatomical, age-related, and species perspectives by Daniel, Steffi, Hulleman, John D.

“…Fibulin-3 (FBLN3, aka EFEMP1) is a secreted extracellular matrix (ECM) glycoprotein implicated in ocular diseases including glaucoma and age-related macular…”
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Overexpression of LLT1 (CLEC2D) in childhood Acute Lymphoblastic Leukemia (ALL) by Mathew, Stephen O, Powers, Sheila, Daniel, Steffi, Jose, Roslin, Aryal, Subhash, Bowman, W. Paul, Mathew, Porunelloor

“…Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the developed world with peak incidence between the ages of 2 and 5 years. Despite…”
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A loss‐of‐function cysteine mutant in fibulin‐3 (EFEMP1) forms aberrant extracellular disulfide‐linked homodimers and alters extracellular matrix composition by Woodard, DaNae R., Daniel, Steffi, Nakahara, Emi, Abbas, Ali, DiCesare, Sophia M., Collier, Gracen E., Hulleman, John D.

“…Fibulin‐3 (F3 or EFEMP1) is a disulfide‐rich, secreted glycoprotein necessary for maintaining extracellular matrix (ECM) and connective tissue integrity. Three…”
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Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones by Ramadurgum, Prerana, Woodard, DaNae R, Daniel, Steffi, Peng, Hui, Mallipeddi, Prema L, Niederstrasser, Hanspeter, Mihelakis, Melina, Chau, Viet Q, Douglas, Peter M, Posner, Bruce A, Hulleman, John D

“…Destabilizing domains (DDs), such as a mutated form of Escherichia coli dihydrofolate reductase (ecDHFR), confer instability and promote protein degradation…”
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Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity by Daniel, Steffi, Renwick, Marian, Chau, Viet Q., Datta, Shyamtanu, Maddineni, Prabhavathi, Zode, Gulab, Wade, Emma M., Robertson, Stephen P., Petroll, W. Matthew, Hulleman, John D.

“…Fibulin-3 (F3) is an extracellular matrix glycoprotein found in basement membranes across the body. An autosomal dominant R345W mutation in F3 causes a macular…”
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Retinal Ganglion Cell Death in Acute and Chronic Models of Glaucoma: Is the Degeneration Subtype Specific? by Daniel, Steffi

“…Glaucoma, the world’s leading cause of irreversible blindness, is a group of optic neuropathies with multifactorial etiologies that lead to optic nerve…”
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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology by DiCesare, Sophia M, Ortega, Antonio J, Collier, Gracen E, Daniel, Steffi, Thompson, Krista N, McCoy, Melissa K, Posner, Bruce A, Hulleman, John D

“…Malattia Leventinese/Doyne honeycomb retinal dystrophy (ML/DHRD) is an age-related macular degeneration-like (AMD-like) retinal dystrophy caused by an…”
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