Search Results - "Daniel, Siegwart"

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles by Dilliard, Sean A., Cheng, Qiang, Siegwart, Daniel J.

“…Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic medicines but have limited therapeutic applications due to liver…”
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Strategies, design, and chemistry in siRNA delivery systems by Dong, Yizhou, Siegwart, Daniel J., Anderson, Daniel G.

“…Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence…”
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Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing by Wei, Tuo, Cheng, Qiang, Min, Yi-Li, Olson, Eric N., Siegwart, Daniel J.

“…CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic…”
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Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing by Cheng, Qiang, Wei, Tuo, Farbiak, Lukas, Johnson, Lindsay T., Dilliard, Sean A., Siegwart, Daniel J.

“…CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with…”
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Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing by Liu, Shuai, Cheng, Qiang, Wei, Tuo, Yu, Xueliang, Johnson, Lindsay T., Farbiak, Lukas, Siegwart, Daniel J.

“…Endosomal escape remains a fundamental barrier hindering the advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that…”
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ATRP in the design of functional materials for biomedical applications by Siegwart, Daniel J., Oh, Jung Kwon, Matyjaszewski, Krzysztof

“…Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety…”
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Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs by Dilliard, Sean A., Siegwart, Daniel J.

“…Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of medicines that directly reprogramme the central dogma of biology to prevent…”
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Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo by Xiong, Hu, Liu, Shuai, Wei, Tuo, Cheng, Qiang, Siegwart, Daniel J.

“…mRNA-based therapeutics have emerged as a promising approach to treat cancer. However, creation of theranostic strategies to both deliver mRNA and…”
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Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I by Cheng, Qiang, Wei, Tuo, Jia, Yuemeng, Farbiak, Lukas, Zhou, Kejin, Zhang, Shuyuan, Wei, Yonglong, Zhu, Hao, Siegwart, Daniel J.

“…mRNA‐mediated protein replacement represents a promising concept for the treatment of liver disorders. Children born with fumarylacetoacetate hydrolase (FAH)…”
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Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA by Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.

“…CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe, non‐viral delivery of CRISPR/Cas components would greatly improve…”
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Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing by Wei, Tuo, Cheng, Qiang, Farbiak, Lukas, Anderson, Daniel G, Langer, Robert, Siegwart, Daniel J

“…CRISPR/Cas9-based genome editing has quickly emerged as a powerful breakthrough technology for use in diverse settings across biomedical research and…”
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Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery by Wang, Xu, Liu, Shuai, Sun, Yehui, Yu, Xueliang, Lee, Sang M., Cheng, Qiang, Wei, Tuo, Gong, Junyu, Robinson, Joshua, Zhang, Di, Lian, Xizhen, Basak, Pratima, Siegwart, Daniel J.

“…A new methodology termed selective organ targeting (SORT) was recently developed that enables controllable delivery of nucleic acids to target tissues. SORT…”
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver by Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H., Zhang, Yu, Gopal, Purva, Tarlow, Branden D., Siegwart, Daniel J., Zhu, Hao

“…Most cells in the liver are polyploid, but the functional role of polyploidy is unknown. Polyploidization occurs through cytokinesis failure and…”
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A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo by Lee, Sang M., Cheng, Qiang, Yu, Xueliang, Liu, Shuai, Johnson, Lindsay T., Siegwart, Daniel J.

“…Lipid nanoparticles (LNPs) represent the leading concept for mRNA delivery. Unsaturated lipids play important roles in nature with potential for mRNA…”
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Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis by Chen, Peiwen, Zuo, Hao, Xiong, Hu, Kolar, Matthew J., Chu, Qian, Saghatelian, Alan, Siegwart, Daniel J., Wan, Yihong

“…Macrophages are prominent immune cells in the tumor microenvironment that exert potent effects on cancer metastasis. However, the signals and receivers for the…”
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Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers by Yan, Yunfeng, Xiong, Hu, Zhang, Xinyi, Cheng, Qiang, Siegwart, Daniel J

“…Messenger RNA (mRNA) has recently come into focus as an emerging therapeutic class with great potential for protein replacement therapy, cancer immunotherapy,…”
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Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy by Zhang, Di, Wang, Guoxun, Yu, Xueliang, Wei, Tuo, Farbiak, Lukas, Johnson, Lindsay T., Taylor, Alan Mark, Xu, Jiazhu, Hong, Yi, Zhu, Hao, Siegwart, Daniel J.

“…Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of…”
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Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes by Liu, Shuai, Wang, Xu, Yu, Xueliang, Cheng, Qiang, Johnson, Lindsay T, Chatterjee, Sumanta, Zhang, Di, Lee, Sang M, Sun, Yehui, Lin, Ting-Chih, Liu, John L, Siegwart, Daniel J

“…Polymers represent a promising therapeutic platform for extrahepatic messenger RNA (mRNA) delivery but are hampered by low in vivo efficacy due to polyplex…”
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Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo by Chen, Zhaoming, Tian, Yang, Yang, Jieyu, Wu, Fapu, Liu, Senyao, Cao, Wenwen, Xu, Weijia, Hu, Tao, Siegwart, Daniel J., Xiong, Hu

“…Lipid nanoparticles (LNPs) represent the most clinically advanced nonviral mRNA delivery vehicles; however, the full potential of the LNP platform is greatly…”
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Tumor-Activated Water-Soluble Photosensitizers for Near-Infrared Photodynamic Cancer Therapy by Xiong, Hu, Zhou, Kejin, Yan, Yunfeng, Miller, Jason B, Siegwart, Daniel J

“…Current photosensitizers (PSs) for photodynamic therapy (PDT) are limited by their low water solubility and tendency to aggregate, low near-infrared (NIR)…”
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