Search Results - "Daniel, Raftery"

Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics by Pan, Zhengzheng, Raftery, Daniel

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Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury by Li, Tao, Zhang, Zhen, Kolwicz, Stephen C., Abell, Lauren, Roe, Nathan D., Kim, Maengjo, Zhou, Bo, Cao, Yang, Ritterhoff, Julia, Gu, Haiwei, Raftery, Daniel, Sun, Haipeng, Tian, Rong

“…Elevated levels of branched-chain amino acids (BCAAs) have recently been implicated in the development of cardiovascular and metabolic diseases, but the…”
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Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy by Gowda, G. A. Nagana, Raftery, Daniel

“…Quantitative NMR-based metabolite profiling is challenged by the deleterious effects of abundant proteins in the intact blood plasma/serum, which underscores…”
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Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis by Ritterhoff, Julia, Young, Sara, Villet, Outi, Shao, Dan, Neto, F. Carnevale, Bettcher, Lisa F., Hsu, Yun-Wei A., Kolwicz, Stephen C., Raftery, Daniel, Tian, Rong

“…Hypertrophied hearts switch from mainly using fatty acids (FAs) to an increased reliance on glucose for energy production. It has been shown that preserving FA…”
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NMR Spectroscopy for Metabolomics Research by Emwas, Abdul-Hamid, Roy, Raja, McKay, Ryan T, Tenori, Leonardo, Saccenti, Edoardo, Gowda, G A Nagana, Raftery, Daniel, Alahmari, Fatimah, Jaremko, Lukasz, Jaremko, Mariusz, Wishart, David S

“…Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the three principal analytical techniques used in metabolomics (the other two…”
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Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy by Nagana Gowda, G. A, Gowda, Yashas N, Raftery, Daniel

“…A current challenge in metabolomics is the reliable quantitation of many metabolites. Limited resolution and sensitivity combined with the challenges…”
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Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit by Nadjsombati, Marija S., McGinty, John W., Lyons-Cohen, Miranda R., Jaffe, James B., DiPeso, Lucian, Schneider, Christoph, Miller, Corey N., Pollack, Joshua L., Nagana Gowda, G.A., Fontana, Mary F., Erle, David J., Anderson, Mark S., Locksley, Richard M., Raftery, Daniel, von Moltke, Jakob

“…In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2s). Here, we…”
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Breast cancer detection using targeted plasma metabolomics by Jasbi, Paniz, Wang, Dongfang, Cheng, Sunny Lihua, Fei, Qiang, Cui, Julia Yue, Liu, Li, Wei, Yiping, Raftery, Daniel, Gu, Haiwei

“…Breast cancer (BC) is a major cause of human morbidity and mortality, especially among women. Despite the important role of metabolism in the molecular…”
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Glucose promotes cell growth by suppressing branched-chain amino acid degradation by Shao, Dan, Villet, Outi, Zhang, Zhen, Choi, Sung Won, Yan, Jie, Ritterhoff, Julia, Gu, Haiwei, Djukovic, Danijel, Christodoulou, Danos, Kolwicz, Stephen C., Raftery, Daniel, Tian, Rong

“…Glucose and branched-chain amino acids (BCAAs) are essential nutrients and key determinants of cell growth and stress responses. High BCAA level inhibits…”
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Colorectal Cancer Detection Using Targeted Serum Metabolic Profiling by Zhu, Jiangjiang, Djukovic, Danijel, Deng, Lingli, Gu, Haiwei, Himmati, Farhan, Chiorean, E. Gabriela, Raftery, Daniel

“…Colorectal cancer (CRC) is one of the most prevalent and deadly cancers in the world. Despite an expanding knowledge of its molecular pathogenesis during the…”
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Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent by Campbell, Matthew D, Djukovic, Danijel, Raftery, Daniel, Marcinek, David J

“…Mitochondria adapt to increased energy demands during muscle contraction by acutely altering metabolite fluxes and substrate oxidation. With age, an impaired…”
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An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers by Airhart, Sophia E, Shireman, Laura M, Risler, Linda J, Anderson, Gail D, Nagana Gowda, G A, Raftery, Daniel, Tian, Rong, Shen, Danny D, O'Brien, Kevin D

“…The co-primary objectives of this study were to determine the human pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine…”
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Metabolic signatures of bacterial vaginosis by Srinivasan, Sujatha, Morgan, Martin T, Fiedler, Tina L, Djukovic, Danijel, Hoffman, Noah G, Raftery, Daniel, Marrazzo, Jeanne M, Fredricks, David N

“…Bacterial vaginosis (BV) is characterized by shifts in the vaginal microbiota from Lactobacillus dominant to a microbiota with diverse anaerobic bacteria. Few…”
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Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls by Lohavanichbutr, Pawadee, Zhang, Yuzheng, Wang, Pei, Gu, Haiwei, Nagana Gowda, G A, Djukovic, Danijel, Buas, Matthew F, Raftery, Daniel, Chen, Chu

“…Oral cavity squamous cell carcinoma (OCC) and oropharyngeal squamous cell carcinoma (OPC) are among the most common cancers worldwide and are associated with…”
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EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape by Lim, Seung-Oe, Li, Chia-Wei, Xia, Weiya, Lee, Heng-Huan, Chang, Shih-Shin, Shen, Jia, Hsu, Jennifer L, Raftery, Daniel, Djukovic, Danijel, Gu, Haiwei, Chang, Wei-Chao, Wang, Hung-Ling, Chen, Mong-Liang, Huo, Longfei, Chen, Chung-Hsuan, Wu, Yun, Sahin, Aysegul, Hanash, Samir M, Hortobagyi, Gabriel N, Hung, Mien-Chie

“…Oncogenic signaling reprograms cancer cell metabolism to augment the production of glycolytic metabolites in favor of tumor growth. The ability of cancer cells…”
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Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes by Lanza, Ian R, Zhang, Shucha, Ward, Lawrence E, Karakelides, Helen, Raftery, Daniel, Nair, K Sreekumaran

“…Insulin is as a major postprandial hormone with profound effects on carbohydrate, fat, and protein metabolism. In the absence of exogenous insulin, patients…”
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Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer by Gu, Haiwei, Pan, Zhengzheng, Xi, Bowei, Asiago, Vincent, Musselman, Brian, Raftery, Daniel

“…Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are the two most commonly used analytical tools in metabolomics, and their…”
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Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart by Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and…”
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Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis by Dempsey, Joseph L, Wang, Dongfang, Siginir, Gunseli, Fei, Qiang, Raftery, Daniel, Gu, Haiwei, Yue Cui, Julia

“…Abstract The gut microbiome regulates important host metabolic pathways including xenobiotic metabolism and intermediary metabolism, such as the conversion of…”
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Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side by Chao, Jennifer R., Knight, Kaitlen, Engel, Abbi L., Jankowski, Connor, Wang, Yekai, Manson, Megan A., Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Hurley, James B., Du, Jianhai

“…Metabolite transport is a major function of the retinal pigment epithelium (RPE) to support the neural retina. RPE dysfunction plays a significant role in…”
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