Search Results - "Daniel, M J"

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants by Crouch, Daniel J. M., Bodmer, Walter F.

“…The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was…”
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Soft matter science and the COVID-19 pandemic by Poon, Wilson C K, Brown, Aidan T, Direito, Susana O L, Hodgson, Daniel J M, Le Nagard, Lucas, Lips, Alex, MacPhee, Cait E, Marenduzzo, Davide, Royer, John R, Silva, Andreia F, Thijssen, Job H J, Titmuss, Simon

“…Much of the science underpinning the global response to the COVID-19 pandemic lies in the soft matter domain. Coronaviruses are composite particles with a core…”
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Phenotype, cancer risk, and surveillance in Beckwith-Wiedemann syndrome depending on molecular genetic subgroups by Maas, Saskia M., Vansenne, Fleur, Kadouch, Daniel J. M., Ibrahim, Abdulla, Bliek, Jet, Hopman, Saskia, Mannens, Marcel M., Merks, Johannes H. M., Maher, Eamonn R., Hennekam, Raoul C.

“…Patients with Beckwith–Wiedemann syndrome (BWS) have an increased risk to develop cancer in childhood, especially Wilms tumor and hepatoblastoma. The risk…”
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Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach by Richardson, Tom G., Crouch, Daniel J. M., Power, Grace M., Morales-Berstein, Fernanda, Hazelwood, Emma, Fang, Si, Cho, Yoonsu, Inshaw, Jamie R. J., Robertson, Catherine C., Sidore, Carlo, Cucca, Francesco, Rich, Steven S., Todd, John A., Davey Smith, George

“…The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D)…”
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Genetic regulation of RNA splicing in human pancreatic islets by Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J M, Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L, Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francois, Todd, John A, Piemonti, Lorenzo, Ferrer, Jorge

“…Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely…”
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Analysis of overlapping genetic association in type 1 and type 2 diabetes by Inshaw, Jamie R. J., Sidore, Carlo, Cucca, Francesco, Stefana, M. Irina, Crouch, Daniel J. M., McCarthy, Mark I., Mahajan, Anubha, Todd, John A.

“…Aims/hypothesis Given the potential shared aetiology between type 1 and type 2 diabetes, we aimed to identify any genetic regions associated with both…”
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Genetics of the human face: Identification of large-effect single gene variants by Crouch, Daniel J. M., Winney, Bruce, Koppen, Willem P., Christmas, William J., Hutnik, Katarzyna, Day, Tammy, Meena, Devendra, Boumertit, Abdelhamid, Hysi, Pirro, Nessa, Ayrun, Spector, Tim D., Kittler, Josef, Bodmer, Walter F.

“…To discover specific variants with relatively large effects on the human face, we have devised an approach to identifying facial features with high…”
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Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells by Inshaw, Jamie R J, Cutler, Antony J, Crouch, Daniel J M, Wicker, Linda S, Todd, John A

“…Immunohistological analyses of pancreata from patients with type 1 diabetes suggest distinct autoimmune islet β-cell pathology between those diagnosed at <7…”
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Functional limitations before and after cancer diagnosis and contributing factors: findings from the China health and retirement longitudinal study by Yang, Rumei, Liu, Yin, Jiang, Yun, Fleming, Daniel J M, Fauth, Elizabeth B

“…Although there is a general trend of functional decline with age, there lacks an understanding of how cancer diagnosis and other factors may contribute to this…”
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Spatially Resolved Water Emission from Gravitationally Lensed Dusty Star-forming Galaxies at z ∼ 3 by Jarugula, Sreevani, Vieira, Joaquin D., Spilker, Justin S., Apostolovski, Yordanka, Aravena, Manuel, Béthermin, Matthieu, Breuck, Carlos de, Chen, Chian-Chou, Cunningham, Daniel J. M., Dong, Chenxing, Greve, Thomas, Hayward, Christopher C., Hezaveh, Yashar, Litke, Katrina C., Mangian, Amelia C, Narayanan, Desika, Phadke, Kedar, Reuter, Cassie A., Werf, Paul Van der, Weiss, Axel

“…Water (H2O), one of the most ubiquitous molecules in the universe, has bright millimeter-wave emission lines that are easily observed at high redshift with the…”
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Effects of Oestrogen on Cognition: What Have We Learned From Basic Research? by Daniel, J. M.

“…The results of clinical and basic research conducted over the past two decades have implicated a role for oestrogen in modulating cognitive function. This…”
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Structural insights into hybrid immiscible blends of metal-organic framework and sodium ultraphosphate glasses by Chester, Ashleigh M, Castillo-Blas, Celia, Sajzew, Roman, Rodrigues, Bruno P, Mas-Balleste, Ruben, Moya, Alicia, Snelson, Jessica E, Collins, Sean M, Sapnik, Adam F, Robertson, Georgina P, Irving, Daniel J. M, Wondraczek, Lothar, Keen, David A, Bennett, Thomas D

“…Recently, increased attention has been focused on amorphous metal-organic frameworks (MOFs) and, more specifically, MOF glasses, the first new glass category…”
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Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies by Green, Hayley M, Fellner, Daniel M J, Finlay, David B, Furkert, Daniel P, Glass, Michelle

“…Positive allosteric modulators (PAMs) of the cannabinoid CB1 receptor (CB ) offer potential therapeutic advantages in the treatment of neuropathic pain and…”
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The neurochemistry and social flow of singing: bonding and oxytocin by Keeler, Jason R, Roth, Edward A, Neuser, Brittany L, Spitsbergen, John M, Waters, Daniel J M, Vianney, John-Mary

“…Music is used in healthcare to promote physical and psychological well-being. As clinical applications of music continue to expand, there is a growing need to…”
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Gene expression in a Drosophila model of mitochondrial disease by Fernández-Ayala, Daniel J M, Chen, Shanjun, Kemppainen, Esko, O'Dell, Kevin M C, Jacobs, Howard T

“…A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory…”
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Work-Family Enrichment: Influence of Job Autonomy on Job Satisfaction of Knowledge Employees by Jing, Song, Li, Zhuoyu, Stanley, Daniel M J J, Guo, Xia, Wenjing, Wang

“…In order to explore the specific path of the influence of job autonomy on the satisfaction of knowledge employees, the current study deduced and established a…”
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Mass and compositional changes, relevant to biorefining, in Miscanthus x giganteus plants over the harvest window by Hayes, Daniel J.M.

“…•Few leaves are lost in the early and late parts of the harvest window.•Most are lost in the period between these phases (mid December and late…”
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Predictive Factors of Negative Spillover From Caregiving to Employment Among Japanese Family Caregivers With Older Relatives in a Care Facility by Honda, Ayumi, Liu, Yin, Fauth, Elizabeth B., Fleming, Daniel J. M., Zarit, Steven H., Maeta, Shunsuke, Date, Yutaka, Tsukigi, Tatsuya, Honda, Sumihisa

“…This cross-sectional study included 211 employed family caregivers with older relatives living in care facilities in Japan. Using multiple linear regression…”
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The Ability of Oestradiol Administration to Regulate Protein Levels of Oestrogen Receptor Alpha in the Hippocampus and Prefrontal Cortex of Middle-Aged Rats is Altered Following Long-Term Ovarian Hormone Deprivation by Bohacek, J., Daniel, J. M.

“…Beneficial effects of oestrogen administration on cognition are attenuated if treatment is initiated following long‐term ovarian hormone deprivation. The…”
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Rehabilitation via HOMe-Based gaming exercise for the Upper limb post Stroke (RHOMBUS): a qualitative analysis of participants’ experience by Kilbride, Cherry, Butcher, Tom, Warland, Alyson, Ryan, Jennifer, Scott, Daniel J M, Cassidy, Elizabeth, Athanasiou, Dimitrios A, Singla-Buxarrais, Guillem, Baker, Karen, Norris, Meriel

“…ObjectiveTo report participants’ experiences of trial processes and use of the Neurofenix platform for home-based rehabilitation following stroke. The…”
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