Search Results - "Daniel, Laura L."

Genome-wide association analyses of common infections in a large practice-based biobank by Jiang, Lan, Kerchberger, V Eric, Shaffer, Christian, Dickson, Alyson L, Ormseth, Michelle J, Daniel, Laura L, Leon, Barbara G Carranza, Cox, Nancy J, Chung, Cecilia P, Wei, Wei-Qi, Stein, C Michael, Feng, QiPing

“…Infectious diseases are common causes of morbidity and mortality worldwide. Susceptibility to infection is highly heritable; however, little has been done to…”
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Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis by Foster, Cerrone R, Daniel, Laura L, Daniels, Christopher R, Dalal, Suman, Singh, Mahipal, Singh, Krishna

“…Ataxia telangiectasia mutated kinase (ATM) is a cell cycle checkpoint protein activated in response to DNA damage. We recently reported that ATM plays a…”
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Clinical associations with a polygenic predisposition to benign lower white blood cell counts by Mosley, Jonathan D., Shelley, John P., Dickson, Alyson L., Zanussi, Jacy, Daniel, Laura L., Zheng, Neil S., Bastarache, Lisa, Wei, Wei-Qi, Shi, Mingjian, Jarvik, Gail P., Rosenthal, Elisabeth A., Khan, Atlas, Sherafati, Alborz, Kullo, Iftikhar J., Walunas, Theresa L., Glessner, Joseph, Hakonarson, Hakon, Cox, Nancy J., Roden, Dan M., Frangakis, Stephan G., Vanderwerff, Brett, Stein, C. Michael, Van Driest, Sara L., Borinstein, Scott C., Shu, Xiao-Ou, Zawistowski, Matthew, Chung, Cecilia P., Kawai, Vivian K.

“…Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is…”
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Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study by Jiang, Lan, Liu, Ge, Oeser, Annette, Ihegword, Andrea, Dickson, Alyson L, Daniel, Laura L, Hung, Adriana M, Cox, Nancy J, Chung, Cecilia P, Wei, Wei-Qi, Stein, C Michael, Feng, Qiping

“…Two risk variants in the apolipoprotein L1 gene ( ) have been associated with increased susceptibility to sepsis in Black patients. However, it remains unclear…”
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Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction by Daniel, Laura L, Scofield, Stephanie L C, Thrasher, Patsy, Dalal, Suman, Daniels, Christopher R, Foster, Cerrone R, Singh, Mahipal, Singh, Krishna

“…Ataxia telangiectasia-mutated kinase (ATM), a cell cycle checkpoint protein, is activated in response to DNA damage and oxidative stress. We have previously…”
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The relationship between high density lipoprotein cholesterol and sepsis: A clinical and genetic approach by Liu, Ge, Jiang, Lan, Kerchberger, V. Eric, Oeser, Annette, Ihegword, Andrea, Dickson, Alyson L., Daniel, Laura L., Shaffer, Christian, Linton, MacRae F., Cox, Nancy, Chung, Cecilia P., Wei, Wei‐Qi, Stein, C. Michael, Feng, QiPing

“…Sepsis accounts for one in three hospital deaths. Higher concentrations of high‐density lipoprotein cholesterol (HDL‐C) are associated with apparent protection…”
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Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity by Daniel, Laura L., Dickson, Alyson L., Zanussi, Jacy T., Miller‐Fleming, Tyne W., Straub, Peter S., Wei, Wei‐Qi, Plummer, W. Dale, Dupont, William D., Liu, Ge, Anandi, Prathima, Reese, Tyler S., Birdwell, Kelly A., Kawai, Vivian K., Hung, Adriana M., Cox, Nancy J., Feng, QiPing, Stein, C. Michael, Chung, Cecilia P.

“…TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could…”
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Deficiency of Ataxia Telangiectasia Mutated Kinase Delays Inflammatory Response in the Heart Following Myocardial Infarction by Daniel, Laura L., Daniels, Christopher R., Harirforoosh, Saghar, Foster, Cerrone R., Singh, Mahipal, Singh, Krishna

“…Background Ataxia‐telangiectasia results from mutations in ataxia telangiectasia mutated kinase (ATM) gene. We recently reported that ATM deficiency attenuates…”
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SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells by Daniel, Laura L., Yang, Tao, Kroncke, Brett, Hall, Lynn, Stroud, Dina, Roden, Dan M.

“…The cardiac sodium channel (SCN5A) mutation R222Q neutralizes a positive charge in the domain I voltage sensor. Mutation carriers display very frequent ectopy…”
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Concurrent Gabapentin and Opioid Use and Risk of Mortality in Medicare Recipients with Non‐Cancer Pain by Corriere, Meghan A., Daniel, Laura L., Dickson, Alyson L., Nepal, Puran, Hall, Kathi, Plummer, W. Dale, Dupont, William D., Murray, Katherine T., Stein, C. Michael, Ray, Wayne A., Chung, Cecilia P.

“…Gabapentin is prescribed for pain and is perceived as safe generally. However, gabapentin can cause respiratory depression, exacerbated by concomitant central…”
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Precision medicine for rheumatologists: lessons from the pharmacogenomics of azathioprine by Daniel, Laura L., Dickson, Alyson L., Chung, Cecilia P.

“…Precision medicine aims to personalize treatment for both effectiveness and safety. As a critical component of this emerging initiative, pharmacogenomics seeks…”
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Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias by Wada, Yuko, Yang, Tao, Shaffer, Christian M., Daniel, Laura L., Glazer, Andrew M., Davogustto, Giovanni E., Lowery, Brandon D., Farber-Eger, Eric H., Wells, Quinn S., Roden, Dan M.

“…Multiple reports associate the cardiac sodium channel gene ( ) variants S1103Y and R1193Q with type 3 congenital long QT syndrome and drug-induced long QT…”
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Race, Genotype, and Azathioprine Discontinuation : A Cohort Study by Dickson, Alyson L, Daniel, Laura L, Jackson, Elise, Zanussi, Jacy, Yang, Wenjian, Plummer, W Dale, Dupont, William D, Wei, Wei-Qi, Nepal, Puran, Hung, Adriana M, Cox, Nancy J, Van Driest, Sara L, Feng, QiPing, Yang, Jun J, Stein, C Michael, Mosley, Jonathan D, Chung, Cecilia P

“…Thiopurines are an important class of immunosuppressants despite their risk for hematopoietic toxicity and narrow therapeutic indices. Benign neutropenia…”
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TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results by Dickson, Alyson L., Daniel, Laura L., Zanussi, Jacy, Dale Plummer, W., Wei, Wei‐Qi, Liu, Ge, Reese, Tyler, Anandi, Prathima, Birdwell, Kelly A., Kawai, Vivian, Cox, Nancy J., Dupont, William D., Hung, Adriana M., Feng, QiPing, Stein, C. Michael, Chung, Cecilia P.

“…Azathioprine is used frequently to treat several inflammatory conditions. However, treatment is limited by adverse events—in particular, myelotoxicity…”
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Duloxetine, Gabapentin, and the Risk for Acute Myocardial Infarction, Stroke, and Out-of-Hospital Death in Medicare Beneficiaries With Non-Cancer Pain by Corriere, Meghan A., Dickson, Alyson L., Daniel, Laura L., Nepal, Puran, Hall, Kathi, Plummer, W. Dale, Dupont, William D., Murray, Katherine T., Stein, C. Michael, Ray, Wayne A., Chung, Cecilia P.

“…Duloxetine is a serotonin-norepinephrine reuptake inhibitor prescribed for musculoskeletal and other forms of chronic pain. Its dual pharmacologic properties…”
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Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β‐adrenergic receptor‐stimulated apoptosis by Foster, Cerrone R., Zha, QinQin, Daniel, Laura L., Singh, Mahipal, Singh, Krishna

“…Ataxia telangiectasia mutated kinase (ATM) is involved in cell cycle checkpoints, DNA repair and apoptosis. β‐Adrenergic receptor (β‐AR) stimulation induces…”
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Common Ancestry-specific Ion Channel Variants Predispose to Drug-induced Arrhythmias by Wada, Yuko, Yang, Tao, Shaffer, Christian M., Daniel, Laura L., Glazer, Andrew M., Davogustto, Giovanni E., Lowery, Brandon D., Farber-Eger, Eric, Wells, Quinn S., Roden, Dan M.

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Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study by Jiang, Lan, Liu, Ge, Oeser, Annette, Ihegword, Andrea, Dickson, Alyson L, Daniel, Laura L, Hung, Adriana M, Cox, Nancy J, Chung, Cecilia P, Wei, Wei-Qi, Stein, C Michael, Feng, Qiping

“…Background: Two risk variants in the apolipoprotein L1 gene ( APOL1 ) have been associated with increased susceptibility to sepsis in Black patients. However,…”
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Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in [beta]-adrenergic receptor-stimulated apoptosis by Foster, Cerrone R, Zha, QinQin, Daniel, Laura L, Singh, Mahipal, Singh, Krishna

“…Ataxia telangiectasia mutated kinase (ATM) is involved in cell cycle checkpoints, DNA repair and apoptosis. [beta]-Adrenergic receptor ([beta]-AR) stimulation…”
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Lack of ATM induces structural and functional changes in the heart: Role in β-adrenergic receptor-stimulated apoptosis by Foster, Cerrone R., Zha, QinQin, Daniel, Laura L., Singh, Mahipal, Singh, Krishna

“…Ataxia telangiectasia mutated kinase (ATM) is involved in cell cycle checkpoints, DNA repair and apoptosis. β-adrenergic receptor (β-AR) stimulation induces…”
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