Search Results - "Daniel, Kelly"

Replenishing the physician-scientist pipeline in the post-late bloomer era by Kelly, Daniel P

“…In a speech, Kelly discusses the call to action to expand and maintain the precious pool of physician-scientists. He would like to begin by reminding everyone…”
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Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues by Burdis, Ross, Kelly, Daniel J.

“…The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure,…”
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Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues by Freeman, Fiona E., Kelly, Daniel J.

“…Alginate is a commonly used bioink in 3D bioprinting. Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that…”
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Skeletal muscle mitochondrial remodeling in exercise and diseases by Gan, Zhenji, Fu, Tingting, Kelly, Daniel P., Vega, Rick B.

“…Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle…”
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Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure by Selvaraj, Senthil, Kelly, Daniel P., Margulies, Kenneth B.

“…Despite existing therapy, patients with heart failure (HF) experience substantial morbidity and mortality, highlighting the urgent need to identify novel…”
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Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers by Daly, Andrew C., Kelly, Daniel J.

“…Successful tissue engineering requires the generation of human scale implants that mimic the structure, composition and mechanical properties of native…”
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Testosterone: a metabolic hormone in health and disease by Kelly, Daniel M, Jones, T Hugh

“…Testosterone is a hormone that plays a key role in carbohydrate, fat and protein metabolism. It has been known for some time that testosterone has a major…”
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Irisin, Light My Fire by Kelly, Daniel P.

“…A newly discovered messenger system between muscle and fat tissue may explain the systemic benefits of exercise. Regular physical activity confers enormous…”
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Medicine. Irisin, light my fire by Kelly, Daniel P

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Mechanical regulation of mesenchymal stem cell differentiation by Steward, Andrew J., Kelly, Daniel J.

“…Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem cells or multipotent stromal cells (MSCs), but the mechanotransductive…”
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Mitochondrial biogenesis and dynamics in the developing and diseased heart by Dorn, 2nd, Gerald W, Vega, Rick B, Kelly, Daniel P

“…The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A…”
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3D printed microchannel networks to direct vascularisation during endochondral bone repair by Daly, Andrew C., Pitacco, Pierluca, Nulty, Jessica, Cunniffe, Gráinne M., Kelly, Daniel J.

“…Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical…”
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Material stiffness influences the polarization state, function and migration mode of macrophages by Sridharan, Rukmani, Cavanagh, Brenton, Cameron, Andrew R., Kelly, Daniel J., O'Brien, Fergal J.

“…[Display omitted] Biomaterial implantation is followed by an inflammatory cascade dominated by macrophages, which determine implant acceptance or rejection…”
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Community Trust and the Ebola Endgame by Dhillon, Ranu S, Kelly, J. Daniel

“…In May, Ebola resurfaced in parts of Guinea thought to be free from the virus. Some infections in known hot spots arise from unknown transmission chains, which…”
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Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Peluso, Michael J, Lu, Scott, Tang, Alex F, Durstenfeld, Matthew S, Ho, Hsi-en, Goldberg, Sarah A, Forman, Carrie A, Munter, Sadie E, Hoh, Rebecca, Tai, Viva, Chenna, Ahmed, Yee, Brandon C, Winslow, John W, Petropoulos, Christos J, Greenhouse, Bryan, Hunt, Peter W, Hsue, Priscilla Y, Martin, Jeffrey N, Daniel Kelly, J, Glidden, David V, Deeks, Steven G, Henrich, Timothy J

“…Abstract Background The biological processes associated with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…”
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Ketones and the Heart: Metabolic Principles and Therapeutic Implications by Matsuura, Timothy R, Puchalska, Patrycja, Crawford, Peter A, Kelly, Daniel P

“…The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced metabolites catabolized in extrahepatic organs. Ketone bodies are a critical…”
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Cardiac maturation by Sakamoto, Tomoya, Kelly, Daniel P.

“…The heart undergoes a dynamic maturation process following birth, in response to a wide range of stimuli, including both physiological and pathological cues…”
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Biomaterial based modulation of macrophage polarization: a review and suggested design principles by Sridharan, Rukmani, Cameron, Andrew R., Kelly, Daniel J., Kearney, Cathal J., O’Brien, Fergal J.

“…Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in…”
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Testosterone: a vascular hormone in health and disease by Kelly, Daniel M, Jones, T Hugh

“…Coronary heart disease is a leading cause of premature death in men. Epidemiological studies have shown a high prevalence of low serum testosterone levels in…”
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Transcriptional integration of mitochondrial biogenesis by Scarpulla, Richard C, Vega, Rick B, Kelly, Daniel P

“…Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the…”
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