Search Results - "Daniel, J"
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Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Published in Cell metabolism (03-04-2018)“…Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and…”
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The Future of Reputation: Gossip, Rumor, and Privacy on the Internet
Published 24-10-2007“…Teeming with chatrooms, online discussion groups, and blogs, the Internet offers previously unimagined opportunities for personal expression and communication…”
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Advances in oral peptide therapeutics
Published in Nature reviews. Drug discovery (01-04-2020)“…Protein and peptide therapeutics require parenteral administration, which can be a deterrent to medication adherence. For this reason, there have been…”
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Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications
Published in Endocrine reviews (01-06-2020)“…Abstract Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and viral infections. The severe acute respiratory…”
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Diagnostic Stewardship—Leveraging the Laboratory to Improve Antimicrobial Use
Published in JAMA : the journal of the American Medical Association (15-08-2017)“…Antimicrobial stewardship programs have emerged as a means to address inappropriate antimicrobial use, manage costs, decrease drug resistance, and prevent…”
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The Cardiovascular Biology of Glucagon-like Peptide-1
Published in Cell metabolism (12-07-2016)“…Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls glucose metabolism and energy homeostasis through regulation of islet…”
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Building an extensible cell wall
Published in Plant physiology (Bethesda) (27-06-2022)“…This article recounts, from my perspective of four decades in this field, evolving paradigms of primary cell wall structure and the mechanism of surface…”
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Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning
Published in Cell metabolism (02-03-2021)“…The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable…”
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Machine learning-aided engineering of hydrolases for PET depolymerization
Published in Nature (London) (28-04-2022)“…Plastic waste poses an ecological challenge 1 – 3 and enzymatic degradation offers one, potentially green and scalable, route for polyesters waste recycling 4…”
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Methods and Mechanisms for Cross-Electrophile Coupling of Csp(2) Halides with Alkyl Electrophiles
Published in Accounts of chemical research (16-06-2015)“…Cross-electrophile coupling, the cross-coupling of two different electrophiles, avoids the need for preformed carbon nucleophiles, but development of general…”
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Fibromyalgia: A Clinical Review
Published in JAMA : the journal of the American Medical Association (16-04-2014)“…IMPORTANCE Fibromyalgia is present in as much as 2% to 8% of the population, is characterized by widespread pain, and is often accompanied by fatigue, memory…”
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Sleep health: can we define it? Does it matter?
Published in Sleep (New York, N.Y.) (01-01-2014)“…Good sleep is essential to good health. Yet for most of its history, sleep medicine has focused on the definition, identification, and treatment of sleep…”
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13
The harmonic mean p-value for combining dependent tests
Published in Proceedings of the National Academy of Sciences - PNAS (22-01-2019)“…Analysis of “big data” frequently involves statistical comparison of millions of competing hypotheses to discover hidden processes underlying observed patterns…”
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Diffuse Growth of Plant Cell Walls
Published in Plant physiology (Bethesda) (01-01-2018)Get full text
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Plant cell wall extensibility: connecting plant cell growth with cell wall structure, mechanics, and the action of wall-modifying enzymes
Published in Journal of experimental botany (01-01-2016)“…The advent of user-friendly instruments for measuring force/deflection curves of plant surfaces at high spatial resolution has resulted in a recent outpouring…”
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Plant Secondary Metabolites as Defenses, Regulators, and Primary Metabolites: The Blurred Functional Trichotomy
Published in Plant physiology (Bethesda) (01-09-2020)“…The plant kingdom produces hundreds of thousands of low molecular weight organic compounds. Based on the assumed functions of these compounds, the research…”
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Re-constructing our models of cellulose and primary cell wall assembly
Published in Current opinion in plant biology (01-12-2014)“…•Cellulose interactions with the matrix depend on microfibril shape.•Physical data point to a microfibril made of 18–24 chains, not 36 chains.•Recent…”
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GLP-1 physiology informs the pharmacotherapy of obesity
Published in Molecular metabolism (Germany) (01-03-2022)“…Glucagon-like peptide-1 receptor agonists (GLP1RA) augment glucose-dependent insulin release and reduce glucagon secretion and gastric emptying, enabling their…”
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Mechanical Stimulation of Piezo1 Receptors Depends on Extracellular Matrix Proteins and Directionality of Force
Published in Nano letters (08-03-2017)“…Piezo receptors convert mechanical forces into electrical signals. In mammals, they play important roles in basic physiological functions including…”
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Insomnia
Published in JAMA : the journal of the American Medical Association (20-02-2013)“…IMPORTANCE Insomnia is one of the most prevalent health concerns in the population and in clinical practice. Clinicians may be reluctant to address insomnia…”
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