Search Results - "Daniel, GW"

Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial by Hodgson, Susanne H, Choudhary, Prateek, Elias, Sean C, Milne, Kathryn H, Rampling, Thomas W, Biswas, Sumi, Poulton, Ian D, Miura, Kazutoyo, Douglas, Alexander D, Alanine, Daniel GW, Illingworth, Joseph J, de Cassan, Simone C, Zhu, Daming, Nicosia, Alfredo, Long, Carole A, Moyle, Sarah, Berrie, Eleanor, Lawrie, Alison M, Wu, Yimin, Ellis, Ruth D, Hill, Adrian V S, Draper, Simon J

“…The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce…”
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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages by Schulthess, Julie, Pandey, Sumeet, Capitani, Melania, Rue-Albrecht, Kevin C., Arnold, Isabelle, Franchini, Fanny, Chomka, Agnieszka, Ilott, Nicholas E., Johnston, Daniel G.W., Pires, Elisabete, McCullagh, James, Sansom, Stephen N., Arancibia-Cárcamo, Carolina V., Uhlig, Holm H., Powrie, Fiona

“…Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective…”
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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages by Palsson-McDermott, Eva M., Curtis, Anne M., Goel, Gautam, Lauterbach, Mario A.R., Sheedy, Frederick J., Gleeson, Laura E., van den Bosch, Mirjam W.M., Quinn, Susan R., Domingo-Fernandez, Raquel, Johnston, Daniel G.W., Jiang, Jian-kang, Israelsen, William J., Keane, Joseph, Thomas, Craig, Clish, Clary, Vander Heiden, Matthew, Xavier, Ramnik J., O’Neill, Luke A.J.

“…Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key…”
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Cardiac output monitoring in children: a review by Cave, Daniel GW, Bautista, Melissa J, Mustafa, Khurram, Bentham, James R

“…Cardiac output monitoring enables physiology-directed management of critically ill children and aids in the early detection of clinical deterioration. Multiple…”
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Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction? by Johnston, Daniel G.W., Kirby, Brian, Tobin, Desmond J.

“…The innate immune system of human skin consists of a multi‐layered barrier consisting of cells and soluble effector molecules charged with maintaining…”
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A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys by Douglas, Alexander D., Baldeviano, G. Christian, Lucas, Carmen M., Lugo-Roman, Luis A., Crosnier, Cécile, Bartholdson, S. Josefin, Diouf, Ababacar, Miura, Kazutoyo, Lambert, Lynn E., Ventocilla, Julio A., Leiva, Karina P., Milne, Kathryn H., Illingworth, Joseph J., Spencer, Alexandra J., Hjerrild, Kathryn A., Alanine, Daniel G.W., Turner, Alison V., Moorhead, Jeromy T., Edgel, Kimberly A., Wu, Yimin, Long, Carole A., Wright, Gavin J., Lescano, Andrés G., Draper, Simon J.

“…Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium…”
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Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5 by Douglas, Alexander D, Williams, Andrew R, Knuepfer, Ellen, Illingworth, Joseph J, Furze, Julie M, Crosnier, Cécile, Choudhary, Prateek, Bustamante, Leyla Y, Zakutansky, Sara E, Awuah, Dennis K, Alanine, Daniel G W, Theron, Michel, Worth, Andrew, Shimkets, Richard, Rayner, Julian C, Holder, Anthony A, Wright, Gavin J, Draper, Simon J

“…There is intense interest in induction and characterization of strain-transcending neutralizing Ab against antigenically variable human pathogens. We have…”
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Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia by Downer, Eric J., Johnston, Daniel G.W., Lynch, Marina A.

“…Accumulating evidence continues to underpin the role of the innate immune system in pathologies associated with neuroinflammation. Innate immunity is regulated…”
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Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions by Payne, Ruth O, Silk, Sarah E, Elias, Sean C, Miura, Kazutoyo, Diouf, Ababacar, Galaway, Francis, de Graaf, Hans, Brendish, Nathan J, Poulton, Ian D, Griffiths, Oliver J, Edwards, Nick J, Jin, Jing, Labbé, Geneviève M, Alanine, Daniel Gw, Siani, Loredana, Di Marco, Stefania, Roberts, Rachel, Green, Nicky, Berrie, Eleanor, Ishizuka, Andrew S, Nielsen, Carolyn M, Bardelli, Martino, Partey, Frederica D, Ofori, Michael F, Barfod, Lea, Wambua, Juliana, Murungi, Linda M, Osier, Faith H, Biswas, Sumi, McCarthy, James S, Minassian, Angela M, Ashfield, Rebecca, Viebig, Nicola K, Nugent, Fay L, Douglas, Alexander D, Vekemans, Johan, Wright, Gavin J, Faust, Saul N, Hill, Adrian Vs, Long, Carole A, Lawrie, Alison M, Draper, Simon J

“…The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In…”
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Improving the tools of clinical pharmacology: Goals for 2017 and beyond by Zineh, I, Abernethy, D, Hop, CECA, Bello, A, McClellan, MB, Daniel, GW, Romine, MH

“…Current trends in pronounced late‐stage attrition rates of promising drug candidates are a pressing concern for patients, providers, and other stakeholders…”
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Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies by Payne, Ruth O, Silk, Sarah E, Elias, Sean C, Milne, Kathryn H, Rawlinson, Thomas A, Llewellyn, David, Shakri, A Rushdi, Jin, Jing, Labbé, Geneviève M, Edwards, Nick J, Poulton, Ian D, Roberts, Rachel, Farid, Ryan, Jørgensen, Thomas, Alanine, Daniel Gw, de Cassan, Simone C, Higgins, Matthew K, Otto, Thomas D, McCarthy, James S, de Jongh, Willem A, Nicosia, Alfredo, Moyle, Sarah, Hill, Adrian Vs, Berrie, Eleanor, Chitnis, Chetan E, Lawrie, Alison M, Draper, Simon J

“…Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite…”
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MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice by Aviello, Gabriella, Corr, Sinéad C, Johnston, Daniel G W, O'Neill, Luke A J, Fallon, Padraic G

“…Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial…”
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eComment. The importance of definition by Hendow, Layth JS, Kadicheeni, Meeriam, Cave, Daniel GW

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Improving evidence developed from population-level experience with targeted agents by McClellan, MB, Daniel, GW, Dickson, D, Perlmutter, J, Berger, DP, Miller, V, Nussbaum, S, Malin, J, Romine, MH, Schilsky, RL

“…Off‐label drug use is common in oncology, due in part to significant unmet medical need, the rarity of many cancers, and the difficulty of conducting…”
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Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins by Wan, Daniel, Ludolf, Fernanda, Alanine, Daniel G W, Stretton, Owen, Ali Ali, Eman, Al-Barwary, Nafal, Wang, Xiaowei, Doenhoff, Michael J, Mari, Adriano, Fitzsimmons, Colin M, Dunne, David W, Nakamura, Ryosuke, Oliveira, Guilherme C, Alcocer, Marcos J C, Falcone, Franco H

“…Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE…”
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P2-17-06: Patterns of Bone Density Evaluation in a Community Population Treated with Aromatase Inhibitors by Ligibel, JA, O'Malley, AJ, Fisher, M, Daniel, GW, Winer, EP, Keating, NL

“…Aromatase inhibitors (AIs) lead to an increased risk of bone loss and fracture. Fracture rates in adjuvant AI studies have ranged from 2.3% to 11%, with higher…”
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Use of Humanised Rat Basophilic Leukaemia Cell Line RS-ATL8 for the Assessment of Allergenicity of Schistosoma mansoni Proteins: e3124 by Wan, Daniel, Ludolf, Fernanda, Alanine, Daniel GW, Stretton, Owen, Ali, Eman Ali, Al-Barwary, Nafal, Wang, Xiaowei, Doenhoff, Michael J, Mari, Adriano, Fitzsimmons, Colin M, Dunne, David W, Nakamura, Ryosuke, Oliveira, Guilherme C, Alcocer, Marcos JC, Falcone, Franco H

“…Background Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of…”
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HM1 EFFICIENCY AND ECONOMIC BENEFITS ASSOCIATED WITH THE USE OF A PAYER-BASED ELECTRONIC HEALTH RECORD IN AN EMERGENCY DEPARTMENT AMONG A HEALTH INSURED POPULATION by Daniel, GW, Ewen, E, Willey, VJ, Shirazi, M, Malone, DC

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PHP10 CHARACTERISTICS OF SENIORS WITH HIGH ANNUAL PRESCRIPTION DRUG EXPENDITURES: FINDINGS FROM THE 2002 AND 2003 MEDICAL EXPENDITURE PANEL SURVEY by Daniel, GW, Malone, DC

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PCN34 ANALYSIS OF DOSE, COST AND USE PATTERNS OF ERYTHROPOIETIN STIMULATING AGENTS IN CANCER PATIENTS by Daniel, GW, Hurley, D, Whyte, J, Grochulski, WD, Willey, VJ, Kallich, J

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