Search Results - "Daniel, Drolet"

Fit for the Eye: Aptamers in Ocular Disorders by Drolet, Daniel W, Green, Louis S, Gold, Larry, Janjic, Nebojsa

“…For any new class of therapeutics, there are certain types of indications that represent a natural fit. For nucleic acid ligands in general, and aptamers in…”
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The Inhibitory Effects of a Factor B-Binding DNA Aptamer Family Supersede the Gain of Function of Factor B Variants Associated with Atypical Hemolytic Uremic Syndrome by Duan, Huiquan, Zhang, Ying, Otis, Matthew R, Drolet, Daniel W, Geisbrecht, Brian V

“…Aptamers are short, single-stranded oligonucleotides that selectively bind to target biomolecules. Although they generally exhibit good binding specificity,…”
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Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B by Xu, Xin, Zhang, Chi, Denton, Dalton T, O'Connell, Daniel, Drolet, Daniel W, Geisbrecht, Brian V

“…The complement system is a conserved component of innate immunity that fulfills diverse roles in defense and homeostasis. Inappropriate activation of…”
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Crossing the Halfway Point: Aptamer-Based, Highly Multiplexed Assay for the Assessment of the Proteome by Kraemer, Stephan, Schneider, Daniel J., Paterson, Clare, Perry, Darryl, Westacott, Matthew J., Hagar, Yolanda, Katilius, Evaldas, Lynch, Sean, Russell, Theresa M., Johnson, Ted, Astling, David P., DeLisle, Robert Kirk, Cleveland, Jason, Gold, Larry, Drolet, Daniel W., Janjic, Nebojsa

“…Measuring responses in the proteome to various perturbations improves our understanding of biological systems. The value of information gained from such…”
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Plasma proteome of growing tumors by Gupta, Shashi, Westacott, Matthew J., Ayers, Deborah G., Weiss, Sophie J., Whitley, Penn, Mueller, Christopher, Weaver, Daniel C., Schneider, Daniel J., Karimpour-Fard, Anis, Hunter, Lawrence E., Drolet, Daniel W., Janjic, Nebojsa

“…Early detection of cancer is vital for the best chance of successful treatment, but half of all cancers are diagnosed at an advanced stage. A simple and…”
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The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects by Hamilton, Marta, Wolf, Julie L., Drolet, Daniel W., Fettner, Scott H., Rakhit, Ashok K., Witt, Karsten, Lum, Bert L.

“…Purpose Erlotinib, N -(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy) quinazolin-4-amine is approved for the treatment for non-small cell lung cancer and pancreatic…”
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Chemical Risk Assessment for Small Businesses: Development of the Chemical Hazard Assessment and Prioritization Risk Tool by Tenkate, Thomas, Kramer, Desre M, Drolet, Daniel, Strahlendorf, Peter, Peters, Cheryl E, Candeloro, Sana, Holness, D. Linn

“…The CHAP-Risk tool uses information from Safety Data Sheets to undertake ‘hazard banding’ to assess the hazard potential of chemicals while also using basic…”
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Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys by Hirota, Masao, Murakami, Ikuo, Ishikawa, Yuichi, Suzuki, Tomoki, Sumida, Shun-ichiro, Ibaragi, Shigeru, Kasai, Hayato, Horai, Naoto, Drolet, Daniel W, Gupta, Shashi, Janjic, Nebojsa, Schneider, Daniel J

“…Interleukin-6 (IL-6) is a potent mediator of inflammatory and immune responses, and a validated target for therapeutic intervention of inflammatory diseases…”
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Pharmacokinetic Properties of DNA Aptamers with Base Modifications by Gupta, Shashi, Drolet, Daniel W, Wolk, Steven K, Waugh, Sheela M, Rohloff, John C, Carter, Jeffery D, Mayfield, Wesley S, Otis, Matthew R, Fowler, Catherine R, Suzuki, Tomoki, Hirota, Masao, Ishikawa, Yuichi, Schneider, Daniel J, Janjic, Nebojsa

“…The addition of novel side chains at the 5-position of uracil is an effective means to increase chemical diversity of aptamers and hence the success rate for…”
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Proteomic Profiles in Advanced Age-Related Macular Degeneration Using an Aptamer-Based Proteomic Technology by Lynch, Anne M, Wagner, Brandie D, Weiss, Sophie J, Wall, Kirsten M, Palestine, Alan G, Mathias, Marc T, Siringo, Frank S, Cathcart, Jennifer N, Patnaik, Jennifer L, Drolet, Daniel W, Janjic, Nebojsa, Mandava, Naresh

“…To explore top-ranked plasma proteins related to neovascular age-related macular degeneration (AMD) and geographic atrophy (GA), and explore pathways related…”
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A nonclinical safety and pharmacokinetic evaluation of N6022: A first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma by Colagiovanni, Dorothy B., Drolet, Daniel W., Langlois-Forget, Emilie, Piché, Marie-Pier, Looker, Doug, Rosenthal, Gary J.

“…► Two weeks of daily N6022 via IV administration was well tolerated. ► High doses of N6022 caused possible liver toxicity related to redox status. ► Inhibiting…”
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Systematic evaluation of the adsorption of organic vapors onto a miniaturized cartridge device using breakthrough tests in parallel experiment with a full size respirator cartridge by Florence Janvier, Ludovic Tuduri, Daniel Cossement, Daniel Drolet, Jaime Lara

“…Breakthrough experiments are essential for the characterization of the adsorption capacity and micropore volume of activated carbon respiratory cartridges and…”
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Phase I, Pharmacokinetic and Biological Correlative Study of OSI-7904L, a Novel Liposomal Thymidylate Synthase Inhibitor, and Cisplatin in Patients with Solid Tumors by RICART, Alejandro D, BERLIN, Jordan D, ROWINSKY, Eric K, ROTHENBERG, Mace L, PAPADOPOULOS, Kyriakos P, SYED, Samira, DROLET, Daniel W, QUARATINO-BAKER, Charlotte, HORAN, Julie, CHICK, Jon, VERMEULEN, Wendy, TOLCHER, Anthony W

“…Purpose: To evaluate the safety and describe the pharmacokinetic profile of OSI-7904L, a novel liposomal thymidylate synthase inhibitor, in combination with…”
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An enzyme-linked oligonucleotide assay by Drolet, Daniel W, Moon-McDermott, Lotus, Romig, Timothy S

“…The recent development of in vitro methods to select high-affinity ligands by combinatorial chemistry methodologies promises unique and theoretically unlimited…”
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Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice by Desjardins, John, Emerson, David L, Colagiovanni, Dorothy B, Abbott, Elizabeth, Brown, Eric N, Drolet, Daniel W

“…OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] is a liposomal formulation of the…”
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A Phase I Study of a New Nucleoside Analogue, OSI-7836, Using Two Administration Schedules in Patients with Advanced Solid Malignancies by LEE, Chooi P, DE JONGE, Maja J. A, KAYE, Stan B, JUDSON, Ian R, VERWEIJ, Jaap, O'DONNELL, Anne E, SCHOTHORST, Kristel L, HANWELL, Janet, CHICK, Jon B, BROOIMANS, Rik A, ADAMS, Laurel M, DROLET, Daniel W, DE BONO, Johann S

“…Purpose: To investigate the safety, tolerability, and pharmacokinetic profile of the novel nucleoside analogue OSI-7836 in patients with advanced solid…”
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POU-domain proteins: structure and function of developmental regulators by Wegner, M, Drolet, D W, Rosenfeld, M G

“…POU-domain proteins are a group of developmental regulators found in organisms as distant as worm and man. The sequence conservation of the POU-domain has…”
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Reduced Fertility in Mice Deficient for the POU Protein Sperm-1 by Pearse, Richard V., Drolet, Daniel W., Kalla, Kristin A., Hooshmand, Farideh, Bermingham, John R., Rosenfeld, Michael G.

“…Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ…”
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Safety Assessment of 4′-Thio-β-d-Arabinofuranosylcytosine in the Beagle Dog Suggests a Drug-Induced Centrally Mediated Effect on the Hypothalamic-Pituitary-Adrenal Axis by Colagiovanni, Dorothy B., Drolet, Daniel W., Dihel, Larry, Meyer, Dennis J., Hart, Karen, Wolf, Julie

“…4′-Thio-β-d-arabinofuranosylcytosine (OSI-7836) is a nucleoside analogue with structural similarity to gemcitabine and cytarabine (ara-C). Myelosuppression,…”
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Micropore characterization of activated carbons of respirator cartridges with argon, carbon dioxide, and organic vapors of different vapor pressures by Janvier, Florence, Tuduri, Ludovic, Cossement, Daniel, Drolet, Daniel, Lara, Jaime

“…Activated carbon is the preferred adsorbent to remove organic vapor (OV) because of its micropore structure. For ten activated carbons of commercially…”
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