Search Results - "Daniel, Andy"
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Glioblastoma remodelling of human neural circuits decreases survival
Published in Nature (London) (18-05-2023)“…Gliomas synaptically integrate into neural circuits 1 , 2 . Previous research has demonstrated bidirectional interactions between neurons and glioma cells,…”
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A virtual innovation bootcamp to remotely connect and empower students to solve COVID-19-related medical problems
Published in Nature biotechnology (01-06-2022)“…An intensive program supplements student education and collaboration while narrowing the disconnect between rising healthcare needs and trainees with the…”
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Optogenetic tools for modulating and probing the epileptic network
Published in Epilepsy research (01-10-2015)“…Highlights • Optogenetics toolbox has already been shown to be somewhat effective at treating seizures in animal models of epilepsy. • Outline the most recent…”
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Functional connectivity within glioblastoma impacts overall survival
Published in Neuro-oncology (Charlottesville, Va.) (25-03-2021)“…Abstract Background Glioblastoma (GBM; World Health Organization grade IV) assumes a variable appearance on MRI owing to heterogeneous proliferation and…”
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Role of inhibitory control in modulating focal seizure spread
Published in Brain (London, England : 1878) (01-07-2018)“…Observed rapid seizure spread through large brain areas seems at odds with the classical view that seizures arise from small foci. Using an acute animal model,…”
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Glial Calcium Waves are Triggered by Seizure Activity and Not Essential for Initiating Ictal Onset or Neurovascular Coupling
Published in Cerebral cortex (New York, N.Y. 1991) (01-06-2017)“…It has been postulated that glia play a critical role in modifying neuronal activity, mediating neurovascular coupling, and in seizure initiation. We…”
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Optical electrocorticogram (OECoG) using wide-field calcium imaging reveals the divergence of neuronal and glial activity during acute rodent seizures
Published in Epilepsy & behavior (01-08-2015)“…Abstract The role of glia in epilepsy has been widely debated. Using in vivo bulk loading of calcium dyes, we imaged neuronal and glial activity in an acute…”
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Machine Learning Analytics of Resting-State Functional Connectivity Predicts Survival Outcomes of Glioblastoma Multiforme Patients
Published in Frontiers in neurology (22-02-2021)“…Glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy. Due to its poor prognosis with currently available treatments, there is a…”
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Resting-State Functional Magnetic Resonance Imaging Networks as a Quantitative Metric for Impact of Neurosurgical Interventions
Published in Frontiers in neuroscience (29-10-2021)“…Resting-state functional MRI (rs-fMRI) has been used to evaluate brain network connectivity as a result of intracranial surgery but has not been used to…”
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Neuro-Oncology Patients as Human Research Subjects: Ethical Considerations for Cognitive and Behavioral Testing for Research Purposes
Published in Cancers (29-01-2022)“…Language, cognition, and behavioral testing have become a fundamental component of standard clinical care for brain cancer patients. Many existing publications…”
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Mapping of the Language Network With Deep Learning
Published in Frontiers in neurology (05-08-2020)“…Pre-surgical functional localization of eloquent cortex with task-based functional MRI (T-fMRI) is part of the current standard of care prior to resection of…”
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Structural gray matter alterations in glioblastoma and high-grade glioma—A potential biomarker of survival
Published in Neuro-oncology advances (01-01-2023)“…Abstract Background Patients with glioblastoma (GBM) and high-grade glioma (HGG, World Health Organization [WHO] grade IV glioma) have a poor prognosis…”
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Homotopic functional connectivity disruptions in glioma patients are associated with tumor malignancy and overall survival
Published in Neuro-oncology advances (01-01-2021)“…Gliomas exhibit widespread bilateral functional connectivity (FC) alterations that may be associated with tumor grade. Limited studies have examined the…”
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Wide-field in vivo neocortical calcium dye imaging using a convection-enhanced loading technique combined with simultaneous multiwavelength imaging of voltage-sensitive dyes and hemodynamic signals
Published in Neurophotonics (Print) (01-07-2014)“…In vivo calcium imaging is an incredibly powerful technique that provides simultaneous information on fast neuronal events, such as action potentials and…”
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CNSC-26. GLIOBLASTOMA-NEURONAL CIRCUIT INTEGRATION IS MODULATED BY INTERLEUKIN-6
Published in Neuro-oncology (Charlottesville, Va.) (10-11-2023)“…Abstract The pleiotropic cytokine interleukin-6 (IL-6) is known to be involved in both pro- and anti-inflammatory signaling cascades. In glioblastoma studies…”
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CNSC-66. STRUCTURAL AND ELECTROPHYSIOLOGICAL CONNECTIVITY IN GLIOBLASTOMA IS MEDIATED BY TUMOR AND IMMUNE DERIVED CYTOKINES
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2024)“…Abstract BACKGROUND In glioblastomas (GBM), the pleiotropic cytokine interleukin-6 (IL-6) upregulates PD-L1 expression. This results in local immunosuppression…”
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TMOD-28. MODELING MICROENVIRONMENTAL DYNAMICS: A NOVEL 3D GLIOMA-NEURON FUSION MODEL
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2024)“…Abstract Gliomas engage in bidirectional interactions with their microenvironment, wherein neuronal activity influences glioma proliferation and gliomas induce…”
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TMOD-16. ZUCLOPENTHIXOL REDUCES ACTIVITY-DEPENDENT GLIOBLASTOMA PROLIFERATION
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2024)“…Abstract A major challenge in modeling glioblastoma in the laboratory is the complex microenvironment in which tumors evolve in humans. The varied architecture…”
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CNSC-29. NKCC1 SIGNALING IN GLIOBLASTOMA REGULATES NEURONAL HYPEREXCITABILITY THROUGH GABAERGIC TONE
Published in Neuro-oncology (Charlottesville, Va.) (10-11-2023)“…Abstract Over 90% of patients with glioma experience tumor-associated epilepsy, however first-line treatment fails to control seizures in most patients. Thus,…”
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