Search Results - "Danhof, M"

Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm by Taneja, A., Della Pasqua, O., Danhof, M.

“…Aim Despite an improved understanding of the molecular mechanisms of nociception, existing analgesic drugs remain limited in terms of efficacy in chronic…”
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Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats by Dahan, A, Yassen, A, Bijl, H, Romberg, R, Sarton, E, Teppema, L, Olofsen, E, Danhof, M

“…There is evidence from animal studies suggesting the existence of a ceiling effect for buprenorphine-induced respiratory depression. To study whether an…”
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Buprenorphine induces ceiling in respiratory depression but not in analgesia by Dahan, A., Yassen, A., Romberg, R., Sarton, E., Teppema, L., Olofsen, E., Danhof, M.

“…We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and…”
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Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques by Teutonico, D., Musuamba, F., Maas, H. J., Facius, A., Yang, S., Danhof, M., Della Pasqua, O.

“…Purpose Clinical Trial Simulations (CTS) are a valuable tool for decision-making during drug development. However, to obtain realistic simulation scenarios,…”
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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research by Danhof, Meindert, de Lange, Elizabeth C.M, Della Pasqua, Oscar E, Ploeger, Bart A, Voskuyl, Rob A

“…The use of pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research is a promising approach that provides better understanding of drug…”
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Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice by Smits, A, De Cock, R F W, Allegaert, K, Vanhaesebrouck, S, Danhof, M, Knibbe, C A J

“…Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to…”
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Mechanism-based PK PD Modeling of the Respiratory Depressant Effect of Buprenorphine and Fentanyl in Healthy Volunteers by Yassen, A, Olofsen, E, Romberg, R, Sarton, E, Teppema, L, Danhof, M, Dahan, A

“…The objective of this study was to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship of buprenorphine and fentanyl for the respiratory…”
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Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans by Dubois, V. F. S., de Witte, W. E. A., Visser, S. A. G., Danhof, M., Della Pasqua, O.

“…Background and Purpose The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are…”
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Pharmacokinetic–pharmacodynamic modelling of drug‐induced QTc interval prolongation in man: prediction from in vitro human ether‐à‐go‐go‐related gene binding and functional inhibition assays and conscious dog studies by Dubois, V F S, Casarotto, E, Danhof, M, Della Pasqua, O

“…Background and Purpose Functional measures of human ether‐à‐go‐go‐related gene (hERG; Kv11.1) channel inhibition have been prioritized as an in vitro screening…”
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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling by Snelder, N, Ploeger, B A, Luttringer, O, Rigel, D F, Fu, F, Beil, M, Stanski, D R, Danhof, M

“…Background and Purpose Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial…”
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Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates by De Cock, R F W, Smits, A, Allegaert, K, de Hoon, J, Saegeman, V, Danhof, M, Knibbe, C A J

“…Cefazolin is frequently administered for antimicrobial prophylaxis and treatment of infections. In neonates, pharmacokinetic observations are limited and…”
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Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain by Taneja, A., Troconiz, I. F., Danhof, M., Della Pasqua, O.

“…Purpose The formalin-induced rat model of nociception involves moderate continuous pain. Formalin-induced pain results in a typical repetitive flinching…”
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Response to letter to the editor from Dr. Mahmood by Strougo, A., Yassen, A., Danhof, M., Freijer, J.

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Response to letter to the editor from Dr. Mahmood: Original publication: “Predicting the ‘first dose in children’ of CYP3A-metabolized drugs: evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages” by Strougo, A, Yassen, A, Danhof, M, Freijer, J

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Pharmacokinetic–pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors by Huntjens, D. R. H., Danhof, M., Della Pasqua, O. E.

“…The mechanism by which COX inhibitors exert their analgesic effect is well established. However, data show no direct correlation between drug concentrations in…”
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Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers by Danhof, Meindert, Alvan, Gunnar, Dahl, Svein G, Kuhlmann, Jochen, Paintaud, Gilles

“…In recent years, pharmacokinetic/pharmacodynamic (PK/PD) modeling has developed from an empirical descriptive discipline into a mechanistic science that can be…”
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A Model-Based Approach to Dose Selection in Early Pediatric Development by Cella, M, Gorter de Vries, F, Burger, D, Danhof, M, Della Pasqua, O

“…The establishment of a rationale for determining dosing regimens in pediatric patients remains a challenge in drug development. In this investigation, we…”
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Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD) by Musuamba, F. T., Teutonico, D., Maas, H. J., Facius, A., Yang, S., Danhof, M., Della Pasqua, O.

“…Purpose Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor…”
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Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis by Gotta, V, Cools, F, Ammel, K, Gallacher, D J, Visser, S A G, Sannajust, F, Morissette, P, Danhof, M, Graaf, P H

“…Background and Purpose Preclinical cardiovascular safety studies (CVS) have been compared between facilities with respect to their sensitivity to detect…”
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PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats by Snelder, N, Ploeger, B A, Luttringer, O, Rigel, D F, Webb, R L, Feldman, D, Fu, F, Beil, M, Jin, L, Stanski, D R, Danhof, M

“…Background and Purpose The homeostatic control of arterial BP is well understood with changes in BP resulting from changes in cardiac output (CO) and/or total…”
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